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Clinical Trial Details — Status: Enrolling by invitation

Administrative data

NCT number NCT02066974
Other study ID # CMUH102-REC2-112
Secondary ID
Status Enrolling by invitation
Phase N/A
First received February 18, 2014
Last updated February 3, 2015
Start date January 2014
Est. completion date February 2016

Study information

Verified date February 2015
Source China Medical University, China
Contact n/a
Is FDA regulated No
Health authority Taiwan: Department of Health
Study type Observational [Patient Registry]

Clinical Trial Summary

Hepatocellular carcinoma (HCC) is a common cause of cancer mortality in Asia. Most patients were presented with advanced disease. Percutaneous ethanol injection, radiofrequency ablation, and transcatheter arterial chemoembolization (TACE) are not considered as a curative treatment and have achieved very limited success in eradicating large HCC or tumors causing portal vein thrombosis. With the development of novel radiotherapy (RT) technique, RT can be safely given to patients with larger tumor or portal vein thrombosis. However, RT could achieve a tumor response rate of approximately 50 %. Currently, there was a paucity of studies regarding a quantitative biomarker to predict tumor response or forecast the outcome in advance. To optimize the therapeutic index, there is a need to seek effective biomarkers for personal medicine because pretreatment AFP is not always useful as a surrogate marker in some of the patients.

The present study is to investigate whether circulating tumor cell genome in peripheral blood can be used to predict RT response in HCC. We will use the blood sample from patients with locally advanced HCC receiving RT. By using next generation sequencing, We are going to explore the quantity and quality changes of DNAs and RNAs in the patient's serum or plasma. By this way, genomic expression in peripheral blood may play a key role in determining the optimal therapeutic strategies for HCC patients by predicting tumor response to RT.


Description:

Patients with hepatocellular carcinoma requiring radiotherapy


Recruitment information / eligibility

Status Enrolling by invitation
Enrollment 45
Est. completion date February 2016
Est. primary completion date February 2016
Accepts healthy volunteers No
Gender Both
Age group 21 Years to 79 Years
Eligibility Inclusion Criteria:

- Patients with unresectable hepatoma with transarterial chemoembolization (TACE) failure or who are not suitable for TACE. A maximal tumor diameter > 3.0 cm

- Age > 20, and < 80 years

- ECOG 0 or 1

- Life expectancy of at least 12 weeks

- Child-Pugh A

- Cancer of the Liver Italian Program (CLIP) score ? 3

- Pretreatment liver function test and renal function test:Total bilirubin < 1.5 times the upper limit of normal (ULN), GOP/GPT ? 5 X of upper limit of normal range, Alkaline phosphatase ? 4X of ULN, Prothrombin time / partial prothrombin time < 1.5 X of ULN, Serum Creatinine ? 1.0 x ULN

- Pretreatment blood count:Hemoglobulin ? 9 g/dl, Absolute neutrophil count ? 1500/mm3,Platelet count ? 100,000/mm3

- Subjects with at least one uni-dimensional or bi-dimensional measurable lesion and lesion must be measured by CT scan

Exclusion Criteria:

- Child-Pugh C

- CLIP score ? 4

- Patients with evidence of extrahepatic or metastatic disease

- Patients with evidence of massive ascites

- Patients receiving previous irradiation to liver

Study Design

Observational Model: Cohort, Time Perspective: Prospective


Related Conditions & MeSH terms


Intervention

Genetic:
hepatoma requiring radiotherapy
hepatoma requiring radiotherapy

Locations

Country Name City State
Taiwan China Medical University Hospital Taichung

Sponsors (1)

Lead Sponsor Collaborator
China Medical University, China

Country where clinical trial is conducted

Taiwan, 

Outcome

Type Measure Description Time frame Safety issue
Primary Response rate The correlation between response rate and circulating tumor cell genome one month No
Secondary Overall survival, relapse-free survival two year No
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