Single Dose of Atorvastatin and Circulating Endothelial Microparticles

Hydroxymethylglutaryl-CoA Reductase Inhibitors Clinical Trial

Official title:

The Effect of Single Dose of Atorvastatin on Change of Circulating Endothelial Microparticles

Clinical Trial Details — Status: Not yet recruiting

Administrative data

• NCT number: NCT02023892
• Other study ID #: YHuang002
• Status: Not yet recruiting
• Phase: Phase 4
• First received: December 18, 2013
• Last updated: May 14, 2014
• Start date: June 2014

Study information

• Verified date: May 2014
• Source: Sun Yat-sen University
• Contact: n/a
• Is FDA regulated: No
• Health authority: China: Food and Drug Administration
• Study type: Interventional

Clinical Trial Summary

Healthy subjects take single dose of 80mg atorvastatin, then measured their circulating endothelial microparticles and flow-mediated vasodilation in the brachial artery by ultrasound at different time points.

Recruitment information / eligibility

• Status: Not yet recruiting
• Enrollment: 30
• Est. primary completion date: August 2014
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Both
• Age group: 18 Years to 30 Years

Eligibility

Inclusion Criteria:

• healthy youth

Exclusion Criteria:

• acute pathologies

• familial history of cardiovascular disease

• smoking or drinking alcohol

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Prevention

Related Conditions & MeSH terms

• Endothelium
• Hydroxymethylglutaryl-CoA Reductase Inhibitors

Intervention

Drug:
• atorvastatin

• placebo

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Sun Yat-sen University

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	change of circulating endothelial microparticles		from 1h to 24h after taking atorvastatin	No