Adult Glioblastoma Clinical Trial
Official title:
Early Detection of Glioma Treatment Response Using MRI-Based Biomarkers
This pilot clinical trial studies advanced magnetic resonance imaging (MRI) techniques in measuring treatment response in patients with high-grade glioma. New diagnostic procedures, such as advanced MRI techniques at 3 Tesla, may be more effective than standard MRI in measuring treatment response in patients receiving treatment for high-grade gliomas.
PRIMARY OBJECTIVES:
I. To correlate treatment-induced changes in quantitative MRI-based biomarkers—specifically,
those sensitive to tumor protein content (amide proton transfer asymmetry [APTasym] from
chemical exchange saturation transfer [CEST]), cellularity (apparent diffusion coefficient
[ADC] from diffusion-weighted imaging [DWI]), and blood flow (volume transfer constant
[K^trans] from dynamic contrast-enhanced [DCE]; cerebral blood flow [CBF] from dynamic
susceptibility contrast [DSC])—with treatment-induced changes in tumor size, measured via
standard anatomic MRI.
II. To correlate treatment-induced changes in the above quantitative MRI endpoints with
patient progression-free survival (PFS).
OUTLINE:
Patients undergo measurement of tumor protein content using CEST-MRI, cellularity using
DWI-MRI, and blood flow using DCE-MRI and DSC-MRI within 2 weeks of treatment and at 2 and 4
weeks after initiation of treatment.
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