A Combined Training Program for Veterans With Amnestic Mild Cognitive Impairment

Amnestic Mild Cognitive Impairment Clinical Trial

Official title:

A Combined Training Program for Veterans With Amnestic Mild Cognitive Impairment

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01962038
• Other study ID #: FAI0002AGG
• Status: Completed
• Phase: N/A
• First received: August 26, 2013
• Last updated: April 3, 2018
• Start date: May 2013
• Est. completion date: November 2017

Study information

• Verified date: April 2018
• Source: Palo Alto Veterans Institute for Research
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The purpose of this study is examine the efficacy of a combination physical exercise and cognitive training program on improving memory in older Veterans with amnestic Mild Cognitive Impairment.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 72
• Est. completion date: November 2017
• Est. primary completion date: July 2017
• Accepts healthy volunteers: No
• Gender: All
• Age group: 50 Years to 90 Years

Eligibility

Inclusion Criteria:

• diagnosis of amnestic Mild Cognitive Impairment

• available informant

• visual and auditory acuity to allow neuropsychological testing

• willingness to participate in exercise training + cognitive training for 8 months

• approval of primary provider to participate in exercise trial

Exclusion Criteria:

• current severe psychiatric disorder

• diagnosis of dementia

• history of neurological or system illness affecting CNS function

• acute illness or unstable chronic illness

• current severe cardiac disease

• inability to exercise consistently because of orthopedic or musculoskeletal problems

• morbid obesity

• inability to read, verbalize understanding and voluntarily sign the informed consent

Related Conditions & MeSH terms

• Amnestic Mild Cognitive Impairment
• Cognitive Dysfunction

Intervention

Behavioral:
• Combined Aerobic and Resistance Exercise
Gym and home based aerobic and resistance exercises
• Stretching Exercises
Gym and home based stretching exercises
• Cognitive Training
Group-based cognitive training

Locations

Country	Name	City	State
United States	VA Palo Alto Health Care System	Palo Alto	California

Sponsors (2)

Lead Sponsor	Collaborator
Palo Alto Veterans Institute for Research	U.S. Army Medical Research and Materiel Command

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Other	Exercise Assessment		Baseline, Time 2, and Time 3
Primary	Change from Baseline to 28 weeks in delayed recall of a word list		Baseline, 24 weeks, 28 weeks
Primary	Change from Baseline to 28 weeks in Delayed Recall of Names-Face Task		Baseline, 24 weeks, 28 weeks
Secondary	Non-Cognitive Outcomes (Depression, Sleep, Quality of Life)		Baseline, Time 2, Time 3