Acute Renal Failure Clinical Trial
Official title:
Minimizing cOntrast utiliZAtion With IVUS Guidance in coRonary angioplasTy: The MOZART Study
Contrast-induced acute kidney injury (CI-AKI) is an important adverse effect of percutaneous
coronary interventions. Despite various efforts, very few preventive measures have been
shown effective in reducing its incidence. The final volume of contrast media utilized
during the procedure is a well-known independent factor affecting the occurrence of CI-AKI.
Intravascular ultrasound (IVUS) has been largely used as an adjunctive diagnostic tool
during percutaneous coronary intervention (PCI). When fully explored, IVUS provides precise
information for guiding the PCI strategy. IVUS allows accurate vessel and lesion sizing,
determination of plaque calcification (and the need for pre-stent plaque preparation),
assessment of post-stent results (including edge dissections and residual lesion, as well as
stent underexpansion or incomplete apposition). Therefore, IVUS has the potential to reduce
the utilization of contrast media during PCI.
In the present study, we hypothesize that IVUS guidance is associated with a significant
reduction in the volume of contrast media during PCI, in comparison to standard
angiography-guided intervention.
n/a
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
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