Influence of Consecutive Strength- and Endurance Regimes on the Myonuclear Domain and Satellite Cell in the M. Vastus Lateralis of Old Healthy Men

Regeneration Potential of Healthy Old Men in Terms of Satellite Cell Activation Clinical Trial

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01905345
• Other study ID #: REGPOT
• Status: Completed
• Phase: N/A
• First received: July 16, 2013
• Last updated: August 4, 2017
• Start date: August 2013
• Est. completion date: August 2017

Study information

• Verified date: August 2017
• Source: University of Zurich
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Randomised training intervention.

Influence of consecutive training regime on the impact of the myonuclear domain and satellite cell

Sarcopenia

Despite that the muscle mass can be positively influenced by training, the loading with high weights and/or to the total exhaustion is for many old persons not possible.

Therefore we aim to enhance the myonuclei in the muscle fiber of old male subjects in a first phase by endurance training, in order to promote a more effective muscle growth in a second phase by resistance exercise.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 30
• Est. completion date: August 2017
• Est. primary completion date: December 2015
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Male
• Age group: 18 Years to 75 Years

Eligibility

Inclusion criteria: -male

• no fever at the beginning and during the study

• between 60 years and 75 years

• non smokers

• no known cardiovascular and orthopaedic problems

• no cardiac pacemaker

• fulfilling the health criteria

Exclusion criteria: -female

• fever or cold at the beginning or during the study

• non MRI compatible metal implants

• under 60 years or over 75 years

• smoker

• cardiovascular or orthopaedic problems

• cardiac pacemaker

• not fulfilling the health criteria

Related Conditions & MeSH terms

• Regeneration Potential of Healthy Old Men in Terms of Satellite Cell Activation

Intervention

Procedure:
• Training

Locations

Country	Name	City	State
Switzerland	University Hospital Zurich, Division of Neurology	Zurich	ZH

Sponsors (1)

Lead Sponsor	Collaborator
University of Zurich

Country where clinical trial is conducted

Switzerland, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Difference in % from baseline in fibre type specific number of satellite cells, fibre type specific myonuclear domain [um^2], myonuclear number [%] in response to consecutive training regimes	Difference in % from baseline in fibre type specific number of satellite cells, fibre type specific myonuclear domain [um^2], myonuclear number [%] in response to consecutive training regimes	participants will be followed for the duration of training period, an expected average of 7 months