Muscle Weakness After Anterior Cruciate Ligament Reconstruction Clinical Trial
Official title:
Could Contralateral Quadriceps Strength Training Attenuate the Strength Loss in the ACL-operated Knee?
| NCT number | NCT01901965 |
| Other study ID # | Contralateral_01 |
| Secondary ID | |
| Status | Completed |
| Phase | N/A |
| First received | |
| Last updated | |
| Start date | May 2013 |
| Est. completion date | November 2016 |
| Verified date | December 2023 |
| Source | Schulthess Klinik |
| Contact | n/a |
| Is FDA regulated | No |
| Health authority | |
| Study type | Interventional |
The main aims of the study are (1) to examine the impact of contralateral strength training on the quadriceps muscle function after ACL surgery and (2) to compare the magnitude of cross-education induced by NMES versus eccentric strength training.
| Status | Completed |
| Enrollment | 36 |
| Est. completion date | November 2016 |
| Est. primary completion date | October 2016 |
| Accepts healthy volunteers | Accepts Healthy Volunteers |
| Gender | All |
| Age group | 18 Years to 50 Years |
| Eligibility | Inclusion Criteria: - patients scheduled for ACL reconstruction surgery Exclusion Criteria: - Concomitant lower limb injury or disorder - previous lower extremity open surgery on the contralateral lower limb - cardiac disease - pregnancy |
| Country | Name | City | State |
|---|---|---|---|
| Switzerland | Neuromuscular Research Laboratory, Schulthess Klinik | Zurich | ZH |
| Lead Sponsor | Collaborator |
|---|---|
| Schulthess Klinik |
Switzerland,
Feil S, Newell J, Minogue C, Paessler HH. The effectiveness of supplementing a standard rehabilitation program with superimposed neuromuscular electrical stimulation after anterior cruciate ligament reconstruction: a prospective, randomized, single-blind study. Am J Sports Med. 2011 Jun;39(6):1238-47. doi: 10.1177/0363546510396180. Epub 2011 Feb 22. — View Citation
Hortobagyi T, Scott K, Lambert J, Hamilton G, Tracy J. Cross-education of muscle strength is greater with stimulated than voluntary contractions. Motor Control. 1999 Apr;3(2):205-19. doi: 10.1123/mcj.3.2.205. — View Citation
| Type | Measure | Description | Time frame | Safety issue |
|---|---|---|---|---|
| Primary | Change in bilateral quadriceps muscle strength [Nm] | 1-2weeks preoperative/ 2weeks/ 8weeks/ 6month | ||
| Primary | Change in quadriceps muscle activation | 1-2 weeks preoperative/ 2weeks/ 8weeks/ 6month | ||
| Secondary | Change in muscle architecture | 1-2 weeks preoperative/ 2weeks/ 8weeks/ 6month | ||
| Secondary | Change in self-reported questionnaire outcomes (KOOS, WOMAClk) | 1-2weeks preoperative/ 2weeks/ 8weeks/ 6 month | ||
| Secondary | functional test outcomes | Assessment of present functional status by means of hop tests | 6month postop |