Non-squamous Non-small Cell Lung Cancer Clinical Trial
Official title:
Phase III Study Comparing the Efficacy of Paclitaxel-bevacizumab With Docetaxel in 2nd or 3rd Line of Treatment of Non Squamous Non Small Cells Lung Cancer
The study objective is to evaluate the efficacy of paclitaxel-bevacizumab comparing to docetaxel. Docetaxel is a standard treatment of 2nd or 3rd line in lung cancer. It was validated by numerous clinical trials but sometimes toxicities are difficult to manage. Bevacizumab is an antiangiogenic treatment which was validated by numerous clinical trials in association with platinum in first ligne. Different clinical and preclinical data suggest that there could exist a synergy between paclitaxel and bevacizumab. This association is already used in metastatic breast cancer, it permits almost to double the response rate and progression free survival. In lung cancer, the association was evaluated by two retrospective studies which demonstrated a benefit with a favourable safety profile.
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| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
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|
Phase 3 | |
| Completed |
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Phase 3 | |
| Completed |
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|
N/A | |
| Completed |
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Phase 2 | |
| Completed |
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Phase 3 | |
| Completed |
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N/A | |
| Completed |
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|
Phase 1 | |
| Completed |
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A Study of Avastin (Bevacizumab) in Combination With Platinum-Containing Chemotherapy in Patients With Advanced or Recurrent Non-Squamous Cell Lung Cancer.
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Phase 4 | |
| Completed |
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Phase 3 | |
| Not yet recruiting |
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N/A | |
| Completed |
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N/A | |
| Completed |
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A Study of RO5083945 in Combination With Chemotherapy Versus Chemotherapy Alone in Patients With Advanced or Recurrent Non-Small Cell Lung Cancer
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Phase 2 | |
| Completed |
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A Study of Erlotinib [Tarceva] as Monotherapy or Intermittent Dosing With Docetaxel in Patients With Advanced or Metastatic Non-Small Cell Lung Cancer. (TALISMAN)
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Phase 2 | |
| Terminated |
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Phase 2 | |
| Withdrawn |
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Phase 2 | |
| Recruiting |
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Phase 2 | |
| Recruiting |
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Phase III Study of AK112 for NSCLC Patients
|
Phase 3 | |
| Completed |
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A Study on the Correlation Between Tarceva (Erlotinib) - Induced Rash and Efficacy in EGFR Mutated Participants With Advanced Non-Small Cell Lung Cancer Receiving First-Line Therapy
|
Phase 2 | |
| Terminated |
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A Study to Assess the Survival of Non-small Cell Lung Cancer Patients Treated With Tarceva After Failed Chemotherapy Treatment.
|
N/A | |
| Completed |
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An Observational Study of Tarceva (Erlotinib) in Patients With Locally Advanced or Metastatic Adenocarcinoma Non-Small Cell Lung Cancer (ELEMENT)
|
N/A |