Postoperative Cognitive Dysfunction Clinical Trial
Official title:
The Difference in Cerebral Oxygenation Between Propofol and Sevoflurane
Verified date | August 2015 |
Source | First Affiliated Hospital, Sun Yat-Sen University |
Contact | n/a |
Is FDA regulated | No |
Health authority | China: Ethics Committee |
Study type | Observational |
the purpose of this study is to investigate whether propofol and sevoflurane have difference effect on cerebral oxygenation .
Status | Completed |
Enrollment | 144 |
Est. completion date | March 2014 |
Est. primary completion date | December 2013 |
Accepts healthy volunteers | No |
Gender | Both |
Age group | 18 Years and older |
Eligibility |
Inclusion Criteria: - scheduled to take major surgery under general anesthesia over 18 years old classified as ASA class three or less Exclusion Criteria: - have a diagnosis of cerebrovascular disorder |
Observational Model: Case Control, Time Perspective: Prospective
Country | Name | City | State |
---|---|---|---|
China | the First Affiliated Hospital of Sun YetSen University | Guang Zhou | Guangdong |
Lead Sponsor | Collaborator |
---|---|
First Affiliated Hospital, Sun Yat-Sen University |
China,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Other | Vital Signs | heart rate, artery blood pressure,pulse oxygen saturation,temperature | baseline , evey hour in the operation,afte extubation | No |
Other | Blood Gas Analysis | including artery blood and blood from jugular vein bulb | baseline,every hour in the operation,after extubation | No |
Primary | the Incidence of Intraoperative Desaturation Between Propofol and Sevoflurane General Anesthesia | SjvO2 were measured before anesthesia, after intubation, every hour during operation, after extubation by jugular vein blood and atrial blood gas analysis.The incidence of intraoperative cerebral desaturation was recorded when SjvO2<50%. | baseline ,every hour in the operation period,after extubation | No |
Secondary | the Incidence of Postoperative Cognitive Disfunction(POCD)Between Propofol and Sevoflurane General Anesthesia | The incidence of early POCD was recorded. The MMSE score and the Montreal cognitive assessment (MoCA) score were recorded 1day before surgery, 1-3 day after surgery and 5-7 day after surgery. The POCD was defined as MMSE score illiterate group = 17, primary and secondary school group = 20, junior high school and above group = 24,or the MoCA score decreased 20% with the baseline. | 1-3days?5-7days after operation | No |
Secondary | the Change in the Level of Serum BDNF(Brain-derived Neurotrophic Factor ) Between Propofol and Sevoflurane Anesthesia | before anesthesia, after extubation ,1day after operation | No | |
Secondary | the Change in the Level of Serum s-100ß Between Propofol and Sevoflurane Anesthesia | before anesthesia,after extubation,1 day after operation | No |
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