Comparison of Carotenoid Bioavailability From Fresh Papaya, Tomato and Carrot

Focus of Study: Carotenoid Absorption Clinical Trial

Official title:

Evaluation of the Effect of the Consumption of Papaya, Tomato, and Carrot on the Bioavailability of Carotenoids

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01748916
• Other study ID #: 2011H0336
• Status: Completed
• Phase: N/A
• Start date: June 2011
• Est. completion date: November 2011

Study information

• Verified date: July 2021
• Source: Ohio State University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The goal of this study is to determine if papaya fruits are an exceptionally good food source for carotenoids in humans, particularly when compared more common carotenoid sources like carrots and tomatoes. This objective will be accomplished by quantitation of the immediate post-prandial plasma concentrations of parent carotenoids and vitamin A metabolites from subjects who consumed a meal containing fresh papaya, tomato, and carrot.

Description:

The main purpose of this study is comparing bioavailability of papaya carotenoids versus carrot and tomato carotenoids. Previously, vitamin A deposition in rat livers was studied, showing that carotenoid bioavailability from papaya is higher than from spinach, parsley and carrots. Detailed knowledge about human carotenoid absorption and conversion from papaya fruit compared to other food sources is still lacking.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 16
• Est. completion date: November 2011
• Est. primary completion date: November 2011
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 70 Years

Eligibility

Inclusion Criteria:

• healthy individuals

Exclusion Criteria:

• lactating, pregnant, or planned to be pregnant

• smokers/those who use tobacco products

• metabolic or malabsorption disorders

• had a history of cancer

• history of liver insufficiency or other gastro-intestinal diseases

• allergy to papaya, carrots or tomatoes

• obesity

Related Conditions & MeSH terms

• Focus of Study: Carotenoid Absorption

Intervention

Other:
• Papaya
Post-prandial study feeding 400-506 g papaya (1.6 mg beta-carotene, 2.1 mg beta-cryptoxanthin, 13 mg lycopene), 150 g yogurt (10% fat), and 45 g of fat free bread.
• Carrot
Post-prandial study feeding 25-35 g carrot (= 1.6 mg beta-carotene), 150 g yogurt (10% fat), and 45 g of fat free bread.
• Tomato
Post-prandial study feeding 256-396 g tomato (= 13 mg lycopene), 150 g yogurt (10% fat), and 45 g of fat free bread.

Locations

Country	Name	City	State
Costa Rica	University of Costa Rica	San José
United States	The Ohio State University	Columbus	Ohio

Sponsors (3)

Lead Sponsor	Collaborator
Ohio State University	Universidad de Costa Rica, University of Hohenheim

Countries where clinical trial is conducted

United States,  Costa Rica, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Pharmacokinetics of Carotenoid Absorption From Papaya, Carrot and Tomato	The primary goal of this research is to investigate whether papaya can deliver increased quantities of carotenoids when compared to carrot and tomato. An area under the curve for concentration of carotenoids (from triglyceride rich lipoprotein (TRL) fraction of plasma) over time will be determined to quantify absorption, after subjects consume a meal containing papaya, carrot or tomato.	8 post-prandial blood samples over 9.5 hours