Disorder Related to Lung Transplantation Clinical Trial
Official title:
Morphofunctional Lung Analysis by Positron Emission Tomography and Computed Tomography After Lung Transplantation
72 hours after lung transplantation, patients undergo a positron emission tomography (PET)
scan and a computed tomography (CT) scan in order to analyse lung function and morphology.
Aim of the study is to analyse complications onset (in particular primary graft
dysfunction), and evaluate 90 days mortality after lung transplantation.
Pulmonary transplantation is considered as a lifesaving procedure in end-stage pulmonary
disease. However morbidity and mortality after lung transplantation are still significant.
Primary graft dysfunction (PGD) is the main cause of early death. PGD is similar to acute
lung injury (ALI)/ acute respiratory distress syndrome (ARDS): oxygenation is compromised,
pulmonary compliance is decreased, chest Rx shows several infiltrates, and alveolar damage
is present.
25% of patients develops PGD within 72 hours from transplantation and 30 days mortality is
eight times higher in patients who develop PGD.
72 hours after lung transplantation, patients, whose clinical condition allow to bring them
to nuclear medicine department, will undergo pulmonary computed tomography (CT) to study
lung morphology and measure lung recruitability and positron emission tomography (PET) to
study lung functionality and estimate lung inflammation.
Aim of this study is to investigate the onset of PGD and other complications and to
determine 72 hours and 90 days mortality after lung transplantation.
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Observational Model: Cohort, Time Perspective: Prospective
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