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Clinical Trial Details — Status: Withdrawn

Administrative data

NCT number NCT01742598
Other study ID # 1106
Secondary ID
Status Withdrawn
Phase N/A
First received
Last updated
Start date December 2015
Est. completion date November 2020

Study information

Verified date February 2019
Source Abbott Medical Devices
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

The purpose of this study is to assess the safety and performance of the 23mm Portico Transcatheter Heart Valve and the TAVI Transapical Delivery System in subjects with severe symptomatic aortic stenosis


Recruitment information / eligibility

Status Withdrawn
Enrollment 0
Est. completion date November 2020
Est. primary completion date July 2016
Accepts healthy volunteers No
Gender All
Age group 65 Years and older
Eligibility Inclusion Criteria:

1. Subject has signed the study Informed Consent Form and Data Protection Form prior to participating in the study.

2. Subject is 65 years of age or older at the time of index procedure, and/or has comorbidities that, in the opinion of the Principal Investigator or the Subject Selection Committee, preclude surgical valve replacement.

3. Subject's aortic annulus is 19-21mm diameter as measured by echocardiography (echo) or CT conducted within 90 days prior to the index procedure.

4. Subject has senile degenerative aortic stenosis with echocardiography derived mean gradient greater than (>) 40mmHg or jet velocity greater than 4.0 m/s or an initial valve area of less than (<) 0.8 cm2 (or aortic valve area index less than or equal to (=) 0.6 cm2/m2). (Baseline measurement taken by echo within 90 days of index procedure).

5. Subject has symptomatic aortic stenosis as demonstrated by NYHA Functional Classification of II, III, or IV.

6. Subject is deemed high operable risk and suitable for TAVI per the medical opinion of the Subject Selection Committee.

7. Subject's predicted operative mortality or serious, irreversible morbidity risk is less than (<) 50% at 30 days post index procedure.

Exclusion Criteria:

1. Subject is unwilling or unable to comply with all study-required follow-up evaluations.

2. Subject has a documented history of a cerebral vascular accident (CVA) or transient ischemic attack (TIA) within 6 months (less than or equal to (=) 180 days) prior to the index procedure.

3. Subject has a chest condition than prevents transapical access.

4. Subject has carotid artery disease requiring intervention.

5. Subject has documented evidence of a myocardial infarction (MI) within 6 months (less than or equal to (=) 180 days) prior to the index procedure.

6. Subject has a native aortic valve that is congenitally unicuspid, bicuspid, quadricuspid or non-calcified as seen by echocardiography.

7. Subject has mitral valvular regurgitation greater than (>) grade III.

8. Subject has moderate or severe mitral stenosis.

9. Subject has aortic root angulation greater than (>) 70 degrees (horizontal aorta).

10. The distance from the left ventricular apex to the aortic annulus is less than (<) 45mm (4.5cm).

11. Subject has a pre-existing prosthetic cardiac device, valve, or prosthetic ring in any position.

12. Subject refuses any blood product transfusion.

13. Subject refuses surgical valve replacement.

14. Subject has left ventricular ejection fraction (LVEF) less than (<) 20%.

15. Subject has documented, untreated symptomatic coronary artery disease (CAD) requiring revascularization.

16. Subject has had a percutaneous interventional or other invasive cardiovascular or peripheral vascular procedure less than or equal to (=) 14 days of index procedure.

17. Subject has severe basal septal hypertrophy that would interfere with transcatheter valve placement.

18. Subject has a history of, or is currently diagnosed with endocarditis.

19. Subject has imaging evidence of intracardiac mass, thrombus, or vegetation.

20. Subject is considered hemodynamically unstable (requiring inotropic support or mechanical heart assistance).

21. Subject is in acute pulmonary edema or requiring intravenous diuretic therapy to stabilize heart failure.

22. Subject with significant pulmonary disease as determined and documented by the Investigator.

23. Subject has significant chronic steroid use as determined and documented by the Investigator.

24. Subject has a documented hypersensitivity or contraindication to anticoagulant or antiplatelet medication.

25. Subject has renal insufficiency as evidenced by a serum creatinine greater than (>) 3.0 mg/dL (265.5µmol/L) or end-stage renal disease requiring chronic dialysis.

26. Subject has morbid obesity defined as a BMI greater than or equal to (=) 40.

27. Subject has ongoing infection or sepsis.

28. Subject has blood dyscrasias (e.g., leukopenia, acute anemia, thrombocytopenia, history of bleeding diathesis, or coagulopathy).

29. Subject has a current autoimmune disease that, in the opinion of the Principal Investigator or the Subject Selection Committee, precludes the subject from study participation.

30. Significant ascending aortic disease documented by diameter greater than 40mm.

31. Subject has an active peptic ulcer or has had gastrointestinal (GI) bleeding within 90 days prior to the index procedure.

32. Subject is currently participating in another investigational drug or device study.

33. Subject requires emergency surgery for any reason.

34. Subject has a life expectancy less than (<) 12 months.

35. Subject has other medical, social or psychological conditions that, in the opinion of the Principal Investigator or the Subject Selection Committee, preclude the subject from study participation.

36. Subject is diagnosed with dementia or admitted to a chronic care facility which would fundamentally complicate rehabilitation from the procedure or compliance with follow-up visits.

37. Subject has a documented allergy to contrast media, nitinol alloys, porcine tissue, or bovine tissue.

Study Design


Related Conditions & MeSH terms


Intervention

Device:
Portico Transapical Aortic Valve System


Locations

Country Name City State
United Kingdom King's College Hospital London

Sponsors (1)

Lead Sponsor Collaborator
Abbott Medical Devices

Country where clinical trial is conducted

United Kingdom, 

Outcome

Type Measure Description Time frame Safety issue
Primary All cause mortality 30 days
Secondary Event rates Cardiovascular mortality
Myocardial Infarction (MI)
Major Stroke
Minor Stroke
Acute Kidney Injury (AKI)
Vascular access site and Access-related complications
Bleeding
Composite of periprocedural encephalopathy, all stroke, and all TIA
30 days
Secondary Functional improvements from baseline NYHA Functional Classification
Six Minute Walk Test
Effective Orifice Area (EOA)
30 days
Secondary Acute device success Successful apical access, delivery and deployment of the device and successful retrieval of the delivery system,
Correct position of the device in the proper anatomical location,
Intended performance of the prosthetic heart valve (Aortic Valve Area greater than (>)1.0 cm2 and mean aortic valve gradient less than (<) 20 mmHg or peak velocity less than (<) 3 m/s, without moderate or severe prosthetic valve AR), and
Only one valve implanted in the proper anatomical location
At time of procedure
See also
  Status Clinical Trial Phase
Not yet recruiting NCT02210351 - Evaluation of Association Between Apical Dysfunction and Trans Apical Access for TAVR, in Patients With Severe Aortic Stenosis, Undergoing Trans Apical Trans Catheter Aortic Valve Replacement (TAP-TAVR). N/A
Completed NCT02956915 - Evaluation of Length of Stay After TF-TAVI
Recruiting NCT05326126 - Microvascular Function in Patients Undergoing Transcatheter Aortic Valve Implant (TAVI) for Severe Symptomatic Aortic Stenosis: Association With Myocardial Fibrosis N/A
Completed NCT04663334 - Change in Coronary Microcirculation and FFR After TAVI in Patients With Cardiovascular Comorbidities
Withdrawn NCT01927601 - Assessment of Neurologic Injury Subsequent to Transcatheter Aortic Valve Replacement: A Feasibility Study N/A
Completed NCT01787084 - Alternative Access Approaches for Transcatheter Aortic Valve Replace (TAVR) in Inoperable Patients With Aortic Stenosis N/A