Neutropenia Clinical Trial
Official title:
Piperacillin/Tazobactam for Prophylaxis in Patients of Neutropenia After Hematopoietic Stem Cell Transplantation - A Pilot Study
Neutropenia is very common in patients received hematopoietic stem cell transplantation,
with median duration of about 14 days. Almost all neutropenia will suffer from febrile
without prophylactic antibiotics. IDSA recommended fluoroquinolones as prophylaxis in
neutropenia patients of high risks, while in China, major pathogens possess high resistance
to fluoroquinolones. It is not clear whether prophylaxis is of benefit, nor the appropriate
prophylaxis regimen.
The current study will evaluate the three different regimen:
1. No prophylaxic antibiotic
2. Piperacillin as prophylaxis for neutropenia patients. Piperacillin has anti-pseudomonas
activity.
3. Piperacillin/tazobactam as prophylaxis for neutropenia patients.
Piperacillin/tazobactam has highest susceptibility rate among common anti-pseudomonas
antibiotics.
1. Swab culture (skin, pharyngeal, nasal, anus) when administered into laminar flow room
after transplantation.
2. Randomize the neutropenia patients into 3 groups.
3. Receive 3 regimen.
4. Full record of clinical data, including background diseases, previous antibiotics
within 90 days, febrile or not at the TOC.
5. For patients developed febrile, imipenem will be prescribed, even if the patient
received no prophylaxis. At the same time, the follow-up ended.
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Prevention
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