Carbohydrate Oxidation and Glycogen Utilization During and Following Exercise Clinical Trial
— CHO-useOfficial title:
Sucrose as a Preferred Carbohydrate in Sports Nutrition
Carbohydrates are an integral component of sports nutrition. Providing carbohydrate (CHO) during exercise delays the onset of fatigue and improves exercise performance by maintaining high rates of CHO oxidation. Traditionally, glucose, or glucose polymers have been the preferential CHO source found in sports drinks. However, during the intestinal absorption of large amounts of glucose (>1.2 g/min), sodium-dependent glucose transporters (SGLT1) may become fully saturated, potentially limiting the rate of exogenous CHO oxidation. In an effort to evade this limitation, research has suggested using multiple transportable carbohydrates in the composition of sports drinks. Multiple transportable carbohydrates are combinations of simple sugars that use different intestinal transporters during the absorption process. Ingesting multiple transportable carbohydrates may enhance the capacity for total intestinal CHO absorption, leading to an increase in the rate of exogenous CHO oxidation. Our purpose will be to examine the disaccharide sucrose in it's ability to provide exogenous fuel during and following prolonged exercise.
| Status | Not yet recruiting |
| Enrollment | 17 |
| Est. completion date | January 2014 |
| Est. primary completion date | September 2013 |
| Accepts healthy volunteers | Accepts Healthy Volunteers |
| Gender | Male |
| Age group | 18 Years to 40 Years |
| Eligibility |
Inclusion Criteria: - Healthy - Male - 18 - 40 years of age - Endurance trained cyclist/triathlete - VO2 max = 50 ml/kg/min - BMI < 25 kg/m2 Exclusion Criteria: - Use of medication - Smoking |
Allocation: Randomized, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Investigator)
| Country | Name | City | State |
|---|---|---|---|
| Netherlands | Maastricht University | Maastricht | Limburg |
| Lead Sponsor | Collaborator |
|---|---|
| Maastricht University Medical Center |
Netherlands,
| Type | Measure | Description | Time frame | Safety issue |
|---|---|---|---|---|
| Primary | Exogenous carbohydrate oxidation rate (Part A) | Carbohydrate oxidation as measured by breath samples | 0 min during trials 1-3 | No |
| Primary | Endogenous carbohydrate oxidation (Part A) | endogenous carbohydrate oxidation as measured through breath samples during trials 1-3 | 0 min during trials 1-3 | No |
| Primary | Glycogen utilization (Part B) | Glycogen utilization measured through a muscle biopsy sample at post (~90 min), 3 and 6 h post exercise. Part B; trials 4-6. |
immediately post exercise (~90min), during trials 4-6 | No |
| Primary | Exogenous carbohydrate oxidation rate (Part A) | Carbohydrate oxidation as measured by breath samples | 30 min during trials 1-3 | No |
| Primary | Exogenous carbohydrate oxidation rate (Part A) | Carbohydrate oxidation as measured by breath samples | 60 min during trials 1-3 | No |
| Primary | Exogenous carbohydrate oxidation rate (Part A) | Carbohydrate oxidation as measured by breath samples | 90 min during trials 1-3 | No |
| Primary | Exogenous carbohydrate oxidation rate (Part A) | Carbohydrate oxidation as measured by breath samples | 120 min during trials 1-3 | No |
| Primary | Exogenous carbohydrate oxidation rate (Part A) | Carbohydrate oxidation as measured by breath samples | 150 min during trials 1-3 | No |
| Primary | Exogenous carbohydrate oxidation rate (Part A) | Carbohydrate oxidation as measured by breath samples | 180 min during trials 1-3 | No |
| Primary | Endogenous carbohydrate oxidation (Part A) | endogenous carbohydrate oxidation as measured through breath samples during trials 1-3 | 30 min during trials 1-3 | No |
| Primary | Endogenous carbohydrate oxidation (Part A) | endogenous carbohydrate oxidation as measured through breath samples during trials 1-3 | 60 min during trials 1-3 | No |
| Primary | Endogenous carbohydrate oxidation (Part A) | endogenous carbohydrate oxidation as measured through breath samples during trials 1-3 | 90 min during trials 1-3 | No |
| Primary | Endogenous carbohydrate oxidation (Part A) | endogenous carbohydrate oxidation as measured through breath samples during trials 1-3 | 120 min during trials 1-3 | No |
| Primary | Endogenous carbohydrate oxidation (Part A) | endogenous carbohydrate oxidation as measured through breath samples during trials 1-3 | 150 min during trials 1-3 | No |
| Primary | Endogenous carbohydrate oxidation (Part A) | endogenous carbohydrate oxidation as measured through breath samples during trials 1-3 | 180 min during trials 1-3 | No |
| Primary | Glycogen utilization (Part B) | Glycogen utilization measured through a muscle biopsy sample at post (~90 min), 3 and 6 h post exercise. Part B; trials 4-6. |
3 h post exercise during trials 4-6 | No |
| Primary | Glycogen utilization (Part B) | Glycogen utilization measured through a muscle biopsy sample at post (~90 min), 3 and 6 h post exercise. Part B; trials 4-6. |
6 h post exercise during trials 4-6 | No |
| Secondary | Indirect calorimetry (Part A) | Measurements of VO2, VCO2 and RER through indirect calorimetry measured every 30 minutes during trials 1-3 | every 30 min up to 180 min during trials 1-3 | No |
| Secondary | Plasma glucose | Plasma glucose measurements | every 30 min up to 180 min during trials 1-6 | No |
| Secondary | Plasma insulin | plasma insulin measurements | every 30 minutes up to 180 min during trials 1-6 | No |