Effect of High-calcium Intake on Appetite, Insulinemia and Incretins

Nutritional and Metabolic Diseases Clinical Trial

Official title:

Effect of High-calcium Intake on Appetite, Insulinemia and Incretins

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01682343
• Other study ID #: 32AN2
• Status: Completed
• Phase: N/A
• First received: September 6, 2012
• Last updated: September 10, 2012
• Start date: May 2012
• Est. completion date: August 2012

Study information

• Verified date: September 2012
• Source: Northumbria University
• Contact: n/a
• Is FDA regulated: No
• Health authority: United Kingdom: Research Ethics Committee
• Study type: Interventional

Clinical Trial Summary

The purpose of this study is to investigate the appetite, insulin and incretin hormone responses to a high-calcium meal.

Description:

Participants will be provided with control and high-calcium meals. Insulin, appetite, glucagon-like peptide-1 and glucose-dependent insulinotropic peptide responses will be assessed, along with rates of substrate oxidation.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 10
• Est. completion date: August 2012
• Est. primary completion date: August 2012
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Male
• Age group: N/A and older

Eligibility

Inclusion Criteria:

• recreationally active

• male

Exclusion Criteria:

• food intolerances/allergies

Study Design

Allocation: Randomized, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Basic Science

Related Conditions & MeSH terms

• Metabolic Diseases
• Nutritional and Metabolic Diseases

Intervention

Dietary Supplement:
• Calcium
Milk-calcium supplement

Locations

Country	Name	City	State
United Kingdom	Northumbria University	Newcastle upon Tyne	Tyne on Wear

Sponsors (1)

Lead Sponsor	Collaborator
Northumbria University

Country where clinical trial is conducted

United Kingdom, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Other	Total fat oxidised during 60 min of exercise (g)	Assessed by indirect calorimetry	1 hour	No
Primary	Subjective appetite ratings	Subjective ratings of appetite assessed by visual analogue scales.	3 hour	No
Secondary	Serum insulin concentration	2 hour area under the curve for serum insulin following breakfast consumption	2 hour	No
Secondary	Plasma glucose-dependent insulinotropic peptide concentration	2 hour area under the curve for plasma glucose-dependent insulinotropic peptide following breakfast consumption	2 hour	No
Secondary	Plasma glucagon-like peptide-1 concentration	2 hour area under the curve for plasma glucagon-like peptide-1 following breakfast consumption	2 hour	No