Intensity-Modulated Radiation Therapy in Treating Younger Patients With Lung Metastases

Unspecified Adult Solid Tumor, Protocol Specific Clinical Trial

Official title: Cardiac-Sparing Whole Lung IMRT in Children and Young Adults With Lung Metastases: A Feasibility Study

Status Completed

Clinical Trial Summary

This pilot clinical trial studies intensity-modulated radiation therapy (IMRT) in treating younger patients with lung metastases. Specialized radiation therapy that delivers a high dose of radiation directly to the tumor may kill more tumor cells and cause less damage to normal tissue.

Clinical Trial Description

OBJECTIVES:

I. To demonstrate the feasibility of delivering cardiac-sparing IMRT in a multi-institutional setting with central quality control for children and young adults with metastatic tumors in the lungs.

II. To prospectively determine the dosimetric advantages of whole lung IMRT treatment over standard whole lung irradiation by comparing treatment plans and different organ dose-volume histograms such as lungs, heart, thyroid gland, liver etc. in all patients enrolled in this study.

III. To determine the short-term efficacy (lung-metastases free survival) and acute tolerance of whole lung IMRT at a minimum period of six months after IMRT.

OUTLINE:

Patients undergo cardiac-sparing whole lung IMRT.

After completion of study treatment, patients are followed up for 1-5 years. ;

Related Conditions & MeSH terms

• Adult Rhabdomyosarcoma
• Kidney Neoplasms
• Lung Metastases
• Lung Neoplasms
• Metastatic Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor
• Neoplasm Metastasis
• Neoplasms
• Neuroectodermal Tumors
• Neuroectodermal Tumors, Primitive
• Neuroectodermal Tumors, Primitive, Peripheral
• Previously Treated Childhood Rhabdomyosarcoma
• Recurrent Adult Soft Tissue Sarcoma
• Recurrent Childhood Rhabdomyosarcoma
• Recurrent Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor
• Recurrent Wilms Tumor and Other Childhood Kidney Tumors
• Rhabdomyosarcoma
• Sarcoma
• Sarcoma, Ewing
• Stage IV Adult Soft Tissue Sarcoma
• Stage IV Wilms Tumor
• Stage V Wilms Tumor
• Unspecified Adult Solid Tumor, Protocol Specific
• Unspecified Childhood Solid Tumor, Protocol Specific
• Wilms Tumor

• NCT number: NCT01586104
• Study type: Interventional
• Source: Ann & Robert H Lurie Children's Hospital of Chicago
• Status: Completed
• Phase: N/A
• Start date: February 2011
• Completion date: September 2015