Muscle Strength Clinical Trial
Official title:
Effect of the Inhibition of the Mammalian Target of Rapamycin on Metabolism and Exercise.
This is an exploratory study based on the hypothesis that kidney transplant patients treated with an immunosuppressive therapy based on an inhibitor of the mammalian target of rapamycin (m-TOR) may increase resistance to physical exercise, which would result in an improvement in the quality of life of these patients.
The hypothesis of the present study is that, with respect to calcineurin inhibitors, the
mTOR inhibitor-based immunosuppression may alter the physical exercise capacity in renal
transplant patients.
This is based on recent data obtained. Regarding metabolism there is evidence that
inhibition of mTOR, reduces muscle glucose utilization, as well as, increase fatty acid
oxidation. On the other hand, has shown that drugs based on mTOR inhibitors in the context
of excess of nutrients improves intracellular glucose uptake in skeletal muscle cells.
Through these mechanisms could increase resistance to physical exercise, which would result
in an improvement in the quality of life of patients. Nevertheless, there isn't any paper
that has explored this hypothesis accurately.
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Endpoint Classification: Pharmacodynamics Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Basic Science
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