Aneurysmal Subarachnoid Hemorrhage Clinical Trial
— PSABOfficial title:
Ultrasound Perfusion Imaging After Aneurysmal Subarachnoid Hemorrhage
The purpose of this study is to examine wether delayed cerebral ischemia can be predicted by ultrasound brain perfusion imaging in patients with aneurysmal subarachnoid hemorrhage (SAH).
Status | Recruiting |
Enrollment | 30 |
Est. completion date | January 2014 |
Est. primary completion date | January 2014 |
Accepts healthy volunteers | No |
Gender | Both |
Age group | 18 Years and older |
Eligibility |
Inclusion Criteria: - Aneurysmal subarachnoid hemorrhage, Hunt and Hess 0-5 - Informed consent - Sufficient transtemporal acoustic window - First examination within 48h after subarachnoid hemorrhage - Minimum Age 18 years Exclusion Criteria: - Contraindication against computed tomographic scan - Incompatibility against SonoVue™ - Acute respiratory distress syndrome - Uncontrollable hypertensive crisis - Severe pulmonary disease(pulmonary hypertension > 90 mmHg) - acute severe cardiac insufficiency (New York Heart Association IV) - known right-left-shunt - pregnancy and breastfeeding - Substance dependence |
Observational Model: Case-Only, Time Perspective: Prospective
Country | Name | City | State |
---|---|---|---|
Germany | Department of Neurology, Asklepios Hospital North | Hamburg |
Lead Sponsor | Collaborator |
---|---|
Asklepios Kliniken Hamburg GmbH |
Germany,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Change of perfusion | Detection of hypoperfusion (defined by 50% or more reduction in beta-value of comparing day 1. with day 5.) in one or more of four regions in one or both hemispheres before the detection of delayed ischemia after SAH in CCT. | Baseline, Day 5 | No |
Secondary | Correlation between perfusion parameters, clinical course and flow velocities | Correlation between perfusion parameters (beta- and A-value), clinical course (National Institute of Health Stroke Scale - NIHSS) and flow velocities in the middle and posterior cerebral artery from day 1 to day 90. | Day 1 to 90 | No |
Secondary | Change of Perfusion | Detection of hypoperfusion (defined by 50% or more reduction in A-value of comparing day 1. with day 5.) in one or more of four regions in one or both hemispheres before the detection of delayed ischemia after SAH in CCT. | Baseline, Day 5 |
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