The Focus of This Study is to Evaluete the Significances of the Vagal Cholinerg Nervuos System for the Effect of GLP-1 by Using Atropin Administration. Clinical Trial
Official title:
The Significances of Atropin Administration for the GLP-1 Potentiation of Glucose Induced Insulin Secretion and the Cephalic Insulin Response
The aim of this study is to investigate the role of transmission of vagal cholinerg for the
GLP-1 potentiation of the glucose stimulated insulin secretion and the cephalic insulin
response by using atropin administration.
The hypothesis is that a great deal of the effects of GLP-1 is mediated via the nervous
system and for this reason the investigators will research individuals with an intact
nervous supply with and without atropin administration.
GLP-1 is a importent enterogastron and incretin hormone. Rapid degradation of GLP-1 by dipeptidyl peptidase 4 (DPP-4) suggests that GLP-1 may act locally (through vagal afferents) before being degraded. We aimed to clarify the role of vagal innervation on the incretin effect. ;
Allocation: Randomized, Endpoint Classification: Pharmacokinetics/Dynamics Study, Intervention Model: Single Group Assignment, Masking: Single Blind (Subject), Primary Purpose: Basic Science