Biomarkers in Samples From Younger Patients With Wilms Tumor

Wilms Tumor and Other Childhood Kidney Tumors Clinical Trial

Official title:

Observational - Relationships Between Tumor-Associated Macrophages and Clinicopathological Factors in Wilms Tumor

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01493817
• Other study ID #: AREN12B1
• Secondary ID: NCI-2012-00093
• Status: Completed
• Phase: N/A
• First received: December 15, 2011
• Last updated: May 17, 2016
• Start date: December 2011

Study information

• Verified date: May 2016
• Source: Children's Oncology Group
• Contact: n/a
• Is FDA regulated: No
• Health authority: United States: Institutional Review Board
• Study type: Observational

Clinical Trial Summary

This research study is studying biomarkers in tissue samples from younger patients with Wilms tumor. Studying samples of tissue from patients with cancer in the laboratory may help doctors identify and learn more about biomarkers related to cancer. It may also help doctors predict how patients respond to treatment

Description:

PRIMARY OBJECTIVES:

I. To determine whether recruitment of tumor-associated macrophages is related to clinicopathological factors in Wilms tumor (tumor stage, presence of vascular invasion, tumor progression, and survival).

OUTLINE:

Paraffin-embedded specimens are analyzed for macrophage markers. Results of each sample are then compared with patient's tumor stage, presence of vascular invasion, tumor progression, and survival.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 30
• Est. primary completion date: May 2016
• Accepts healthy volunteers: No
• Gender: Both
• Age group: N/A and older

Eligibility

Inclusion Criteria:

• Wilms tissue microarray samples provided by the Children's Oncology Group

Study Design

Observational Model: Case-Only, Time Perspective: Retrospective

Related Conditions & MeSH terms

• Kidney Neoplasms
• Wilms Tumor
• Wilms Tumor and Other Childhood Kidney Tumors

Intervention

Other:
• laboratory biomarker analysis
Correlative studies

Locations

Country	Name	City	State
United States	Children's Oncology Group	Monrovia	California

Sponsors (2)

Lead Sponsor	Collaborator
Children's Oncology Group	National Cancer Institute (NCI)

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Relationship of tumor-associated macrophages and prognosis	Correlation of each type of macrophage score with tumor staging, presence of vascular invasion, and disease-free survival will be assessed.	1 month	No