Recurrent Glioblastoma Multiforme Clinical Trial
Official title:
Prospective Randomized Phase II Trial of Hypofractionated Stereotactic Radiotherapy in Recurrent Glioblastoma Multiforme
Glioblastoma multiforme (GBM) is the most common primary brain tumor in adults. The treatment comprises maximal safe resection followed by radiotherapy and chemotherapy. Despite appropriate management, 90% of the patients will develop relapse or progression. After progression, the median survival is 5.2 months (Stupp, 2009). The treatment of GBM relapse remains investigational. Reirradiation is an option in selected cases. The objective of this study is to compare 2 schemes of stereotactic hypofractionated radiotherapy in the management of recurrent GBM.
n/a
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT00597493 -
Ph. 2 Sorafenib + Protracted Temozolomide in Recurrent GBM
|
Phase 2 | |
| Completed |
NCT00379470 -
Effect of NovoTTF-100A in Recurrent Glioblastoma Multiforme (GBM)
|
Phase 3 | |
| Recruiting |
NCT01737346 -
Procarbazine and Lomustine in Recurrent Glioblastoma
|
Phase 2 | |
| Active, not recruiting |
NCT00562419 -
CT-322 in Treating Patients With Recurrent Glioblastoma Multiforme and Combination Therapy With Irinotecan
|
Phase 2 | |
| Completed |
NCT00071539 -
Safety and Efficacy Study to Treat Recurrent Grade 4 Malignant Brain Tumors
|
Phase 2 | |
| Active, not recruiting |
NCT02062827 -
Genetically Engineered HSV-1 Phase 1 Study for the Treatment of Recurrent Malignant Glioma
|
Phase 1 | |
| Completed |
NCT00509301 -
Safety & Radiation Distribution Study of Cotara® in Patients With Recurrent Glioblastoma Multiforme
|
Phase 1 | |
| Recruiting |
NCT05868083 -
The Safety and Efficacy of SNC-109 CAR-T Cells Therapy the Recurrent Glioblastoma
|
Phase 1 | |
| Completed |
NCT01576666 -
Phase Ib, Dose Escalation Study of Oral LDE225 in Combination With BKM120 in Patients With Advanced Solid Tumors
|
Phase 1 | |
| Completed |
NCT01738646 -
Ph II SAHA and Bevacizumab for Recurrent Malignant Glioma Patients
|
Phase 2 | |
| Completed |
NCT00306618 -
Safety and Efficacy Study of Panzem NCD to Treat Glioblastoma
|
Phase 2 | |
| Completed |
NCT01934361 -
Phase Ib/II Study of Buparlisib Plus Carboplatin or Lomustine in Patients With Recurrent Glioblastoma Multiforme
|
Phase 1 | |
| Terminated |
NCT04915404 -
Berubicin in Adult Patients With Recurrent Glioblastoma Multiforme (WHO Grade IV)
|
Phase 1/Phase 2 | |
| Terminated |
NCT01756729 -
Post-approval Study of NovoTTF-100A in Recurrent GBM Patients
|
Phase 4 | |
| Completed |
NCT00747253 -
Monteris AutoLITT™ FIM Safety Trial for Recurrent/Progressive Brain Tumors
|
Phase 1 | |
| Completed |
NCT00883298 -
Bi-weekly Temozolomide Plus Bevacizumab for Adult Patients With Recurrent Glioblastoma Multiforme
|
Phase 2 | |
| Completed |
NCT00481455 -
Phase 2 Study of Panzem Nanocrystal Colloidal Dispersion (NCD) in Combination With Fixed-Dose Temozolomide to Patients With Recurrent Glioblastoma Multiforme (GBM)
|
Phase 2 | |
| Recruiting |
NCT03423628 -
A Study to Assess the Safety and Tolerability of AZD1390 Given With Radiation Therapy in Patients With Brain Cancer
|
Phase 1 | |
| Recruiting |
NCT04689087 -
A Prospective, Open-label, Single-arm Clinical Study
|
N/A |