Post Hematopoietic Stem Cell Transplantation Clinical Trial
Official title:
Pulmonary Disease in Patients Undergoing Hematopoietic Stem Cell Transplantation.
Verified date | October 2015 |
Source | Ohio State University |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational |
This will be a retrospective study and analysis of subjects who have undergone a
hematopoietic stem transplant (either at OSUMC or external location) and were seen at OSUMC
at any time between 01Jan2000 and 30Jun2011.
This study will determine factors influencing pulmonary disease and associated treatment
strategies.
Status | Completed |
Enrollment | 200 |
Est. completion date | July 8, 2016 |
Est. primary completion date | July 8, 2016 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years and older |
Eligibility |
Inclusion Criteria: - Adult patients who have undergone a hematopoietic stem transplant (either at OSUMC or external location) and were seen at OSUMC at any time between 01Jan2000 and 30Jun2011. - Age > 18 years Exclusion Criteria: - Age <18 years - Prisoners |
Country | Name | City | State |
---|---|---|---|
United States | The Ohio State University Medical Center | Columbus | Ohio |
Lead Sponsor | Collaborator |
---|---|
Karen Wood |
United States,
Afessa B, Litzow MR, Tefferi A. Bronchiolitis obliterans and other late onset non-infectious pulmonary complications in hematopoietic stem cell transplantation. Bone Marrow Transplant. 2001 Sep;28(5):425-34. Review. — View Citation
Dudek AZ, Mahaseth H, DeFor TE, Weisdorf DJ. Bronchiolitis obliterans in chronic graft-versus-host disease: analysis of risk factors and treatment outcomes. Biol Blood Marrow Transplant. 2003 Oct;9(10):657-66. — View Citation
Verleden GM, Vanaudenaerde BM, Dupont LJ, Van Raemdonck DE. Azithromycin reduces airway neutrophilia and interleukin-8 in patients with bronchiolitis obliterans syndrome. Am J Respir Crit Care Med. 2006 Sep 1;174(5):566-70. — View Citation
Vos R, Vanaudenaerde BM, Verleden SE, De Vleeschauwer SI, Willems-Widyastuti A, Van Raemdonck DE, Schoonis A, Nawrot TS, Dupont LJ, Verleden GM. A randomised controlled trial of azithromycin to prevent chronic rejection after lung transplantation. Eur Respir J. 2011 Jan;37(1):164-72. doi: 10.1183/09031936.00068310. — View Citation
Williams KM, Chien JW, Gladwin MT, Pavletic SZ. Bronchiolitis obliterans after allogeneic hematopoietic stem cell transplantation. JAMA. 2009 Jul 15;302(3):306-14. doi: 10.1001/jama.2009.1018. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | A retrospective diagnostic review on pulmonary disease related to hematopoietic stem cell transplantation. | To determine factors influencing pulmonary disease related to HSCT. | Up to 15 years | |
Secondary | A retrospective treatment review on treatment strategies for pulmonary disease related to hematopoietic stem cell transplantation. | To review treatment strategies for pulmonary disease post transplant for effectiveness. | Up to 15 years |
Status | Clinical Trial | Phase | |
---|---|---|---|
Active, not recruiting |
NCT02928185 -
Adaptation of Skills Training Manuals for Patients Receiving Hematopoietic Stem Cell Transplantation and Their Caregivers
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