Fracture, Closed, Comminuted, Healing Clinical Trial
Official title:
The Efficacy of Low-Magnitude, High Frequency Vibration Treatment on Accelerating the Healing of Femoral Shaft Fracture - A Prospective Randomized Controlled Clinical Trial
Diaphyseal long bone fractures are usually associated with high energy trauma in which
femoral shaft fracture is one common fracture in young age group. Surgery is usually needed
for the diaphyseal lone bone fractures and the painful conditions always hinder weight
bearing which is important for fracture healing and functional recovery. Fracture healing in
cortical bone is less predictable than trabecular bone because they are less active and
blood supply is more critical. Therefore accelerating fracture healing and rehabilitation of
long bone fracture will absolutely bring significant economic benefit to the society in term
of hospitalization and sick leave cost.
Low-magnitude, high-frequency vibration (LMHFV) treatment can provide systemic mechanical
stimulation and is reported with multiple effects on musculoskeletal tissues. LMHFV can
enhance the blood circulation and osteogenic effect in normal subjects and animals. Our
previous clinical study also indicated that LMHFV could enhance the balancing ability and
muscular function in normal post-menopausal women after treating whole-body vibration. For
the fracture healing effect, an acceleration of healing by inducing callus formation and
maturation in rat model was also reported in our previous studies.
In this study a total of 50 unilateral closed femoral shaft fracture patients of either
gender aged 20-40 years old will be recruited and they will be randomized to either control
and vibration group. The vibration group will be treated with LMHFV for 6 months. The
findings of this study will provide very useful scientific data to support the application
of LMHFV for fracture healing.
n/a
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Investigator, Outcomes Assessor), Primary Purpose: Treatment
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