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Cisplatin and Pemetrexed With Radiation Followed by Lobectomy — CisPemXetSrg  

Nonsquamous Nonsmall Cell Neoplasm of Lung Clinical Trial

Official title:
A Phase I Trial of Preoperative Carboplatin or Cisplatin and Pemetrexed With Thoracic Radiation Therapy Followed by Lobectomy in Resectable Stage III Patients With Non-Squamous Non Small Cell Lung Cancer (NSCLC)

Clinical Trial Summary

This study is open to patients that have been diagnosed with non-squamous Stage III Non Small Cell Lung Cancer (NSCLC) and will have surgery to remove the tumor.

The purpose of this study is to:

- Test a combination of two chemotherapeutic drugs along with radiation therapy, when given prior to surgery and see what effects (good or bad) it has on someone with this type of cancer. Chemotherapeutic drugs selectively destroy diseased cancer cells and tissues.

- Test the safety of different dose levels of radiation when given with each combination of chemotherapy;

- Determine what side effects are associated with combining radiation with these two chemotherapy combinations.

Clinical Trial Description

n/a

Study Design

Allocation: Non-Randomized, Endpoint Classification: Safety/Efficacy Study, Masking: Open Label, Primary Purpose: Treatment

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01373463
Study type Interventional
Source Medical University of South Carolina
Contact
Status Terminated
Phase Phase 1
Start date May 2011
Completion date June 2012
View Details
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