Exercise and Non-exercise Effect Upon Vitamins E and C Clinical Trial
Official title:
Modulation of Insulin and Exercise Responses by Vitamin E and Vitamin C
Moderate exercise is thought to be one of the best known means to improve how insulin works in people. Taking vitamin C and vitamin E is also thought to have the same effect. This study is being done to see if taking vitamin C and vitamin E improves or hinders how insulin works when people do not exercise and when they do exercise.
| Status | Terminated |
| Enrollment | 1 |
| Est. completion date | March 2012 |
| Est. primary completion date | March 2012 |
| Accepts healthy volunteers | Accepts Healthy Volunteers |
| Gender | Both |
| Age group | 30 Years to 50 Years |
| Eligibility |
Inclusion Criteria: - 30 to 50 years of age - Willing to not change eating habits - Willing to not change physical activity habits - Willing to complete the 28 week study - Able to swallow pills Exclusion Criteria: - smoke or use tobacco or nicotine in any form including snuff, pills, and patches - take any medication that makes you unable to do hard exercise - have cardiovascular, pulmonary, and/or a metabolic disease such as diabetes - have uncontrolled high blood pressure - have alcohol, anabolic steroids, or other substance abuse issues - consume more than 3 alcoholic drinks/week - have any joint or muscle injuries that affects your ability to exercise - have cancer (other than skin cancer or carcinoma in situ of the cervix) - are pregnant or nursing |
Allocation: Randomized, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Caregiver, Investigator), Primary Purpose: Basic Science
| Country | Name | City | State |
|---|---|---|---|
| United States | Grand Forks Human Nutrition Research Center | Grand Forks | North Dakota |
| Lead Sponsor | Collaborator |
|---|---|
| USDA Grand Forks Human Nutrition Research Center |
United States,
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* Note: There are 22 references in all — Click here to view all references
| Type | Measure | Description | Time frame | Safety issue |
|---|---|---|---|---|
| Primary | (1) Blood glucose and insulin following glucose challenge in non-exercising and exercising people (BMI 27 to 35) taking anti-oxidants (vitamin E and vitamin C) or placebo. | Individuals will be in placebo and vitamin supplemented groups in a cross-over design. A total of 6 oral glucose tolerance tests will be performed per subject in the study. | 28 weeks | No |
| Secondary | (1) Resting metabolic rate, body composition, plasma oxidative stress, plasma vitamin E and vitamin C levels in non-exercising and exercising people (BMI 27 to 35) taking anti-oxidants (vitamin E and vitamin C) or placebo. | 28 weeks | No | |
| Secondary | (2) Fitness measures (heart rate, exercise work, VO2, VCO2, blood lactate) in non-exercising and exercising people (BMI 27 to 35) taking anti-oxidants (vitamin E and vitamin C) or placebo. | 28 weeks | No |