Anesthetic Ventilatory Requirements Clinical Trial
Official title:
Dead Space Effect of an Anaesthesia Gas Reflector (AnaConDa)
| Verified date | September 2014 |
| Source | Region Skane |
| Contact | n/a |
| Is FDA regulated | No |
| Health authority | Sweden: Medical Products Agency |
| Study type | Interventional |
The anesthesia gas reflector (AnaConDa) is built on the adsorptive capacity of active carbon which also adsorbs carbon dioxide in exhaled air. Rebreathing of carbon dioxide thus occurs and must be compensated for by increased ventilation. This study aims at determining how much compensation must be given, based on the hypothesis that rebreathing depends on carbon dioxide level in blood and exhaled air.
| Status | Completed |
| Enrollment | 6 |
| Est. completion date | January 2013 |
| Est. primary completion date | January 2013 |
| Accepts healthy volunteers | No |
| Gender | Both |
| Age group | 18 Years and older |
| Eligibility |
Inclusion Criteria: - elective coronary artery by-pass graft surgery - elective valve replacement surgery - normal left ventricular ejection fraction on preoperative echocardiography Exclusion Criteria: - obstructive lung disease - restrictive lung disease |
Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Basic Science
| Country | Name | City | State |
|---|---|---|---|
| Sweden | University Hospital, Cardiothoracic Intensive Care | Lund |
| Lead Sponsor | Collaborator |
|---|---|
| Region Skane |
Sweden,
Sturesson LW, Bodelsson M, Johansson A, Jonson B, Malmkvist G. Apparent dead space with the anesthetic conserving device, AnaConDa®: a clinical and laboratory investigation. Anesth Analg. 2013 Dec;117(6):1319-24. doi: 10.1213/ANE.0b013e3182a7778e. — View Citation
| Type | Measure | Description | Time frame | Safety issue |
|---|---|---|---|---|
| Primary | Airway Dead Space With Devices for Heat and Moisture Exchange of Respiratory Gas. | A conventional heat and moisture exchanger used in a respiratory circuit during anasthesia was exchanged by an AnaConDa. The AnaConDa causes re-breathing of carbon dioxide which clinically is equivalent to an increased airway dead space. The total airway dead space effect of the AnaConDa, i.e. volume of the device plus rebreathing from the charcoal filter was measured using the Single Breath Test for carbon dioxide, as was airway deadspace of the conventional Heat and Moisture Exchanger. Airway dead space differences between devices was calculated by subtraction of volumes thus achieved. Difference= Airway dead space AnaConDa - Airway dead space conventional Heat and Moisture Exchanger. | 1 hour | No |