Clinical Trials Logo
  1. Home
  2. Other
  3. NCT01327443

Exercise Versus Diet in the Treatment of Nonalcoholic Fatty Liver Disease

Non Alcoholic Fatty Liver Disease Clinical Trial

Official title:
Exercise Versus Diet in the Treatment of Nonalcoholic Fatty Liver Disease

Clinical Trial Summary

The central hypothesis of this proposal is that a reduction in hepatic mitochondrial function is the main pathophysiology behind NAFLD (Non-Alcoholic Fatty Liver Disease) and NASH (Non alcoholic steatohepatitis). The investigators further hypothesize that lifestyle modifications through aerobic exercise training without weight loss or diet-induced weight loss are effective in reducing NAFLD parameters by improving hepatic mitochondrial content and function in human subjects.

The investigators propose a randomized, controlled human clinical trial to compare the effects of aerobic exercise training (without weight loss) versus diet-induced weight loss (without exercise) in individuals who have NAFLD or liver biopsy-confirmed NASH

Clinical Trial Description

Fatty Liver Disease) and NASH (Non alcoholic steatohepatitis). The investigators further hypothesize that lifestyle modifications through aerobic exercise training without weight loss or diet-induced weight loss are effective in reducing NAFLD parameters by improving hepatic mitochondrial content and function in human subjects.

The investigators propose a randomized, controlled human clinical trial to compare the effects of aerobic exercise training (without weight loss) versus diet-induced weight loss (without exercise) in individuals who have NAFLD or liver biopsy-confirmed NASH ;

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01327443
Study type Interventional
Source University of Missouri-Columbia
Contact
Status Completed
Phase N/A
Start date October 2010
Completion date October 2015
View Details
See also
  Status Clinical Trial Phase
Active, not recruiting NCT02248311 - "Preventing Cardiovascular Ischemic Events and Arresting Their Consequences in Type 2 Diabetic Population N/A
Completed NCT01277237 - The Effect Of Omega-3 Fatty Acids on Non-alcoholic Fatty Liver Disease Phase 3
Active, not recruiting NCT04442620 - Prevention and Reversion of NAFLD in Obese Patients With Metabolic Syndrome by Mediterranean Diet and Physical Activity N/A
Completed NCT01999101 - Safety Pilot Study of Farnesoid X Receptor (FXR) Agonist in Non-alcoholic Fatty Liver Disease (NAFLD) Patients Phase 2
Active, not recruiting NCT01482065 - The Sleep, Liver Evaluation and Effective Pressure Study N/A
Completed NCT03135873 - Mastiha Treatment for Obese With NAFLD Diagnosis N/A
Completed NCT02686476 - Effect of Empagliflozin on Liver Fat Content in Patients With Type 2 Diabetes N/A
Completed NCT02820285 - Characterization of Immune Semaphorin in Non Alcoholic Fatty Liver Disease and NASH N/A
Completed NCT01556113 - Genetic Effect on Omega 3 Fatty Acids for the Treatment of Fatty Liver Disease N/A
Recruiting NCT06080386 - UDFF Performance Evaluation ((Ultrason Derived Fat Fraction)
Terminated NCT02134522 - The Role of Obstructive Sleep Apnea in Children With Fatty Liver Disease N/A
Completed NCT01553500 - Glucomannan Effects on Children With Non-alcoholic Fatty Liver Disease Phase 2
Completed NCT05426382 - A Digital Solution for Individuals With Non Alcoholic Fatty Liver Disease N/A
Completed NCT03300661 - Non Alcoholic Fatty Liver Disease: Nutritional Epidemiology and Lifestyle Medicine N/A
Not yet recruiting NCT02178839 - The Effect of Oral β- Glucan Supplement on Appetite and Insulin Resistance in Non Alcoholic Fatty Liver Disease N/A
Recruiting NCT02038387 - Prospective Clinical Study of the Role of the Immune Response, in Relation to Diet, in Patients Affected by Either Chronic Hepatitis C Virus (HCV) Infection or Non Alcoholic Fatty Liver Disease (NAFLD) N/A
Completed NCT01634048 - The Effect of Protein-enriched Diet on Body Composition and Appetite N/A
Completed NCT01874249 - Non Invasive Assessment of Liver Fibrosis in Fatty Liver Disease N/A
Completed NCT01966627 - Genetics of Fatty Liver Disease in Children N/A
Terminated NCT01842282 - Amlexanox for Type 2 Diabetes and Obesity Phase 2