Non-Hodgkin's Lymphoma Clinical Trial
Official title:
A Phase I Dose Finding Study Of Panobinostat In Children With Refractory Hematologic Malignancies
This study is for patients with relapsed or refractory Acute Lymphoblastic Leukemia (ALL),
Acute Myelogenous Leukemia (AML), Hodgkin's Disease (HD) or Non-Hodgkin's Lymphoma (NHL).
Panobinostat is a new drug that is considered investigational because it has not been
approved in the United States by the Food and Drug Administration (FDA), or in any other
country. Panobinostat is a histone deacetylase inhibitor (HDACi) and interferes with gene
expression found in cells causing them to stop growing or die. Panobinostat has been used in
several hundred adults who had leukemia, HD, NHL and other solid tumors. Panobinostat has
not been given to children.
This is a phase I study. In a phase I study, drugs are tested to the highest dose that can
be safely given. Drugs are given at gradually increasing dosages until there are
unacceptable side effects. The goal of the Phase I study is to find out the dose of
panobinostat that can be safely given to children with relapsed ALL, AML, HD and NHL.
n/a
Allocation: Non-Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
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