Incontinence, Overactive Bladder, Stress Urinary Incontinence Clinical Trial
Official title:
Investigation of the Suburothelial Myofibroblast Network and of Smooth Muscle Function and Control in the Continent and Incontinent Human Urinary Outflow Tract
| NCT number | NCT01227447 |
| Other study ID # | RO 3589/2-1 |
| Secondary ID | |
| Status | Recruiting |
| Phase | N/A |
| First received | October 22, 2010 |
| Last updated | March 2, 2012 |
| Start date | January 2010 |
The aim is to find out if adreno-muscarinic synergy is present also in human tissues of the urinary outflow tract that have a dual adrenergic-muscarinic receptor fitting. To further characterise morphology and function of the suburothelial myofibroblast network in the human bladder outlet.
| Status | Recruiting |
| Enrollment | 200 |
| Est. completion date | |
| Est. primary completion date | |
| Accepts healthy volunteers | Accepts Healthy Volunteers |
| Gender | Both |
| Age group | 18 Years and older |
| Eligibility |
Inclusion Criteria: Tissue will be collected from the operation theatre only after having obtained the patient´s consent and in strictest accordance with histopathological requirements, i.e. after assessment of resection margins. It might be necessary to retrieve the tissue from the pathologist after first pathological assessment is completed. Tissue will be placed in Tyrode´s solution, gassed with 95 % O2 and 5 % CO2, for functional and RT-PCR or Western blot experiments, or in OCT (optimal cutting temperature) compound, snap-frozen in liquid nitrogen, and stored in a -80°C freezer until cutting for immunohistochemical experiments. Exclusion Criteria: |
Time Perspective: Prospective
| Country | Name | City | State |
|---|---|---|---|
| Germany | Ludwig Maximilians University Munich, Dep Urology | Munich |
| Lead Sponsor | Collaborator |
|---|---|
| Ludwig-Maximilians - University of Munich |
Germany,