Healthy Young and Elderly Volunteers Clinical Trial
Official title:
Pharmacodynamics of Intravenous Citalopram in the Elderly: a Functional Magnetic Resonance Imaging Analysis
| NCT number | NCT01216449 |
| Other study ID # | 08-39 |
| Secondary ID | |
| Status | Terminated |
| Phase | N/A |
| First received | |
| Last updated | |
| Start date | April 2009 |
| Est. completion date | March 2016 |
| Verified date | March 2020 |
| Source | Rotman Research Institute at Baycrest |
| Contact | n/a |
| Is FDA regulated | No |
| Health authority | |
| Study type | Interventional |
Antidepressant medications known as selective serotonin reuptake inhibitors (SSRIs) are most commonly prescribed to treat depression and anxiety. How antidepressants work on the brain to alter mood and behaviour is not well understood. This study will use a brain scanning technique (functional magnetic resonance imaging) to examine how aging impacts brain activation during emotional tasks after the administration of intravenous (IV) citalopram (this is the only SSRI available in this form, and is well tolerated and safe in young and old adults). The investigators will further determine what role genetic differences play in this relationship. The investigators expect to see an increase in brain signal as the concentration of IV citalopram increases. However, the investigators propose that the brain signal in older adults will not be as strong as in younger adults. Furthermore, the investigators expect that participants genetically predisposed to have fewer serotonin transporters (the site of action of SSRIs) will show greater decreases in brain activation with citalopram.
| Status | Terminated |
| Enrollment | 29 |
| Est. completion date | March 2016 |
| Est. primary completion date | October 2011 |
| Accepts healthy volunteers | Accepts Healthy Volunteers |
| Gender | Male |
| Age group | 20 Years and older |
| Eligibility |
Inclusion Criteria: - Male aged 60 or older (elderly group) - Male aged 20-40 (younger adult group) - English speaking - Right-handed - Non-smoker - Score of 27 or greater on the Mini Mental State Exam Exclusion Criteria: - Unstable medical, cardiac, or neurological illness (including stroke, brain tumour, epilepsy, significant head injury, Alzheimer's, Parkinson's or Huntington's disease) - Laboratory results indicating unanticipated illness or intolerability of blood drawing procedures or of study drug - Current or lifetime Axis-I psychiatric diagnosis on the DSM-IV/SCID (i.e., Module A: Mood, Module F: Anxiety, Module B & C: Psychosis) - History of drug or alcohol abuse within one year, or lifetime history of alcohol or drug dependence (i.e., SCID Module E: Substance Abuse, or clinically significant urine toxicology screen) - History of non-tolerance to SSRI therapy; including history of SSRI-related syndrome of inappropriate antidiuretic hormone secretion (SIADH) or sinus bradycardia on ECG (less than 50 beats per minute) - Contraindication to MRI (as per MRI Contraindication Screening Form) |
| Country | Name | City | State |
|---|---|---|---|
| Canada | Rotman Research Institute at Baycrest | Toronto | Ontario |
| Lead Sponsor | Collaborator |
|---|---|
| Rotman Research Institute at Baycrest | Centre for Addiction and Mental Health, University of Toronto |
Canada,
| Type | Measure | Description | Time frame | Safety issue |
|---|---|---|---|---|
| Primary | BOLD fMRI Response | Changes in affect-related neuronal activation as measured by blood oxygenation level-dependent (BOLD) fMRI response to IV citalopram are the primary outcome measures. Imaging data will be compared between IV citalopram and placebo administration and young and old adults. | Visit 1, Visit 2 | |
| Secondary | Genetics and Cognitive/Emotional Change | Secondary measures include analysis of the relationship between 5HTT polymorphism and neuronal activation, and changes in cognitive and emotional assessments between IV citalopram and placebo. | Visit 1, Visit 2 |