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Clinical Trial Details — Status: Completed

Administrative data

NCT number NCT01188603
Other study ID # 511.146
Secondary ID
Status Completed
Phase Phase 1
First received August 24, 2010
Last updated May 15, 2014
Start date July 2010
Est. completion date October 2010

Study information

Verified date May 2014
Source Sprout Pharmaceuticals, Inc
Contact n/a
Is FDA regulated No
Health authority United States: Food and Drug Administration
Study type Interventional

Clinical Trial Summary

This trial examines the way flibanserin is metabolized in postmenopausal women with Hypoactive Sexual Desire Disorder.


Recruitment information / eligibility

Status Completed
Enrollment 24
Est. completion date October 2010
Est. primary completion date October 2010
Accepts healthy volunteers No
Gender Female
Age group N/A and older
Eligibility Inclusion criteria:

1. Patients must be in a stable, monogamous heterosexual relationship for at least one year.

2. Patients must have a primary diagnosis of Hypoactive Sexual Desire Disorder for at least six months.

3. Patients must be naturally postmenopausal women of any age with at least one ovary.

4. Patients may participate whether or not they are currently taking systemic hormone therapy provided the therapy was not prescribed for treatment of low sexual desire. Hormone therapy must be at a stable dose for at least six months.

Exclusion criteria:

1. Patients with a history of drug dependence or abuse within the past twelve months.

2. Patients who have been previously treated with flibanserin.

3. Patients who have sexual dysfunctions other than Hypoactive Sexual Desire Disorder, such as: Sexual Aversion Disorder, Substance-Induced Sexual Dysfunction, Dyspareunia, Vaginismus, Gender Identity Disorder,Paraphilia, or Sexual Dysfunction due to a general medical condition.

4. Patients who indicate that their sexual partner has inadequately treated organic or psychosexual dysfunction that could interfere with a patients response to treatment.

5. Patients whose sexual function was impaired, in the investigators opinion, by abdominal or vaginal hysterectomy, oophorectomy or any other pelvic, vaginal, or urologic surgery.

6. Patients with pelvic pain, pelvic inflammatory disease, endometriosis, urinary tract or vaginal infection/vaginitis, cervicitis, interstitial cystitis, vulvodynia, symptomatic vaginal atrophy or any other gynecological pathology requiring further evaluation.

7. Patients with a history of unexplained vaginal bleeding within the past twelve months.

8. Patients with a history of Major Depressive Disorder within six months prior to Screening; ; active suicidal ideation with intent in the past ten years or suicidal behavior at any time.

9. Patients with a history of any other psychiatric disorder that could impact sexual function, increase risks to patient safety, or impair patient compliance. Such disorders include but are not limited to bipolar disorder, psychotic disorders, severe anxiety, eating disorders, and antisocial personality disorders.

10. Clinically significant electrocardiogram abnormalities at Screening.

11. Patients with a history of dementia or other neurodegenerative disease; organic brain disease; stroke; transient ischemic attacks; multiple sclerosis; spinal cord injury; brain surgery; significant brain trauma; peripheral neuropathy; and epilepsy.

12. Patients with ongoing hepatic impairment (cirrhosis, hepatic tumor, or other hepatic disease); peptic ulcer within six months prior to Screening; elevated liver enzymes ; inflammatory bowel disease; gastrointestinal bleeding within two months prior to Screening; Patients who have had bariatric surgery for obesity.

13. Patients with a history of angina; atherosclerotic cardiovascular disease; congestive heart failure; cardiomyopathy; symptomatic cardiac valve disease; arrhythmia; hypertension.

14. Patients with a history of renal failure; known history of chronic glomerulonephritis.

15. Patients with a history of chronic obstructive pulmonary disease, chronic bronchitis, or asthma not well controlled with medication taken twice daily or less.

16. Patients with a history of gonadotrophic hormone disorders or uncontrolled diabetes mellitus.

17. Uncorrected hypothyroidism or hyperthyroidism.

18. Patients with a history of uncontrolled glaucoma.

19. Patients with known Human Immunodeficiency Virus infection, Acquired Immunodeficiency Syndrome, other clinically significant immunological disorders or auto-immune disorders such as lupus or scleroderma.

20. Patients with a history of any cancer within the past ten years, other than non-invasive, previously resected basal cell carcinoma of the skin.

Study Design

Endpoint Classification: Safety Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment


Related Conditions & MeSH terms

  • Sexual Dysfunctions, Psychological

Intervention

Drug:
flibanserin 100 mg dose every evening
all subjects receive flibanserin

Locations

Country Name City State
United States 511.146.01001 Boehringer Ingelheim Investigational Site Kalamazoo Michigan
United States 511.146.01004 Boehringer Ingelheim Investigational Site Knoxville Tennessee
United States 511.146.01003 Boehringer Ingelheim Investigational Site Orlando Florida
United States 511.146.01005 Boehringer Ingelheim Investigational Site Wichita Kansas

Sponsors (1)

Lead Sponsor Collaborator
Sprout Pharmaceuticals, Inc

Country where clinical trial is conducted

United States, 

Outcome

Type Measure Description Time frame Safety issue
Primary Flibanserin: Area Under the Curve; AUC_0-8 Geometric mean of the AUC_0-8 of Flibanserin 8 days No
Primary Flibanserin: AUC t,ss Geometric mean of the AUC t,ss of Flibanserin 8 days No
Primary Flibanserin: Cmax (Peak Concentration) Geometric mean of the Cmax of Flibanserin 8 days No
Primary Flibanserin: Cmax,ss Geometric mean of the Cmax,ss of Flibanserin 8 days No
Primary Flibanserin: Tmax,ss Median of the tmax,ss of Flibanserin 8 days No
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