Pulmonary Disease, Chronic Obstructive Clinical Trial
Official title:
A Randomized, Active-controlled, Double-blind, Double-dummy, Parallel Group Design, Multi-center Trial to Compare the Efficacy and Safety of 2.5 µg and 5 µg Tiotropium Inhalation Solution Delivered by the Respimat Inhaler With Tiotropium Inhalation Capsules 18 µg Delivered by the HandiHaler (TIOSPIR)
Direct comparison studies of the tiotropium HandiHaler® 18 µg and Respimat® 5 µg formulations have been limited to 4-week crossover studies. Therefore, prospective data from a trial of adequate size and duration is required to establish that compared to tiotropium HandiHaler®, tiotropium Respimat® will have (a) similar effects on safety and (b) similar or superior effects on exacerbations.
| Status | Completed |
| Enrollment | 17183 |
| Est. completion date | May 2013 |
| Est. primary completion date | May 2013 |
| Accepts healthy volunteers | No |
| Gender | Both |
| Age group | 40 Years and older |
| Eligibility |
Inclusion criteria: 1. All patients must sign an informed consent consistent with International Conference on Harmonization Good Clinical Practice (ICH-GCP) guidelines prior to participation in the trial, which includes medication washout and restrictions. 2. Male or female patients 40 years of age or older. 3. Patients must be current or ex-smokers with a smoking history of =10 pack-years. (Patients who have never smoked cigarettes must be excluded) 4. All patients must have a diagnosis of COPD (P06-12085), and must meet the following criteria: Relatively stable airway obstruction with a post-bronchodilator FEV1 = 70% of predicted normal and post-bronchodilator FEV1 / FVC =70%. Pulmonary function tests (PFTs) were conducted after the inhalation of 400 µg salbutamol / albuterol (preferred), however testing with either 200 µg salbutamol/albuterol or a combination of salbutamol / albuterol with ipratropium bromide (2 to 4 actuations) was acceptable. Other short-acting beta agonists, such as terbutaline, may have been used for the testing. The medication used for the testing was documented. Further, historical data from measurements within the past 6 months either at the site or at a referral site may have been used (see Section 6.2.1 of the CTP, located in Appendix 16.1.1). Subjects were not to have been randomized to the study without the availability of spirometry data at the actual study site. Eligibility for PFT sub-study: For subjects participating in the spirometry sub-study, historical data may not have been used for inclusion. These subjects must have qualified in the clinic at Visit 1 after performing a baseline measurement. These subjects performed a pre-dose PFT which was followed by the administration of 400 µg salbutamol / albuterol only (no other short-acting beta agonist was allowed), followed by a post-dose PFT for qualification. 5. Able to inhale from the HandiHaler® and the Respimat® devices. Exclusion criteria: 1. Significant diseases other than COPD. A significant disease is defined as a disease or condition which, in the opinion of the investigator, may put the patient at risk because of participation in the study or may influence the patients ability to participate in the study. 2. Patients with a recent history (i.e., six months or less) of myocardial infarction. 3. Patients with any unstable or life-threatening cardiac arrhythmia requiring intervention or change in drug therapy during the last year. 4. Hospitalisation for cardiac failure (New York Heart Association (NYHA) Class III or IV) during the past year. 5. Known active tuberculosis. 6. Patients with a history of asthma, cystic fibrosis, clinically evident bronchiectasis, interstitial lung disease, or pulmonary thromboembolic disease. 7. History of thoracotomy with pulmonary resection. Subjects with a history of thoracotomy for other reasons were to have been evaluated per exclusion criterion 1. 8. Subject was planning to undergo lung transplant or lung volume reduction surgery (LVRS). 9. Malignancy for which the subject had undergone resection, radiation, chemotherapy or biological treatments within the last 5 years. Subjects with treated basal cell carcinoma were allowed. 10. Known respiratory infection or exacerbation of COPD in the 4 weeks prior to randomization. 11. Known hypersensitivity to anticholinergic drugs, lactose, benzalkonium chloride (BAC), ethylenediaminetetraacetic acid (EDTA), or any other components of the HandiHaler® or Respimat® inhalation solution delivery system. 12. Known moderate to severe renal impairment (as judged by the investigator). 13. Known narrow angle glaucoma. 14. Known significant symptomatic prostatic hyperplasia or bladder-neck obstruction. Subjects whose symptoms were controlled on treatment may have been included. 15. Use of systemic corticosteroid medication at unstable doses (i.e., less than 6 weeks on stable dose) or at doses in excess of the equivalent of 10 mg prednisolone per day. 16. Pregnant or nursing women or women of childbearing potential not using a medically approved means of contraception for at least 3 months prior to and for the duration of the trial. 17. Significant alcohol or drug abuse within the past 12 months. 18. Subjects requiring the use of supplemental oxygen therapy for > 12 hours per day. 19. Subjects who had completed a pulmonary rehabilitation program in the 6 weeks prior to the screening visit or subjects who were currently in a pulmonary rehabilitation program that was not maintained throughout the duration of the study. 20. Subjects who had taken an investigational drug within 30 days prior to the Screening Visit. 21. Previous participation (receipt of randomized treatment) in this study. 22. Subjects who were currently participating in an interventional study. |
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double-Blind, Primary Purpose: Treatment
| Country | Name | City | State |
|---|---|---|---|
| Argentina | 205.452.54003 Boehringer Ingelheim Investigational Site | Capital Federal | |
| Argentina | 205.452.54011 Boehringer Ingelheim Investigational Site | Capital Federal | |
| Argentina | 205.452.54013 Boehringer Ingelheim Investigational Site | Capital Federal | |
| Argentina | 205.452.54027 Boehringer Ingelheim Investigational Site | Capital Federal | |
| Argentina | 205.452.54029 Boehringer Ingelheim Investigational Site | Capital Federal | |
| Argentina | 205.452.54031 Boehringer Ingelheim Investigational Site | Capital Federal | |
| Argentina | 205.452.54025 Boehringer Ingelheim Investigational Site | Florencio Varela | |
| Argentina | 205.452.54007 Boehringer Ingelheim Investigational Site | Mar del Plata | |
| Argentina | 205.452.54015 Boehringer Ingelheim Investigational Site | Mar del Plata | |
| Argentina | 205.452.54001 Boehringer Ingelheim Investigational Site | Mendoza | |
| Argentina | 205.452.54019 Boehringer Ingelheim Investigational Site | Monte Grande | |
| Argentina | 205.452.54005 Boehringer Ingelheim Investigational Site | Quilmes | |
| Argentina | 205.452.54009 Boehringer Ingelheim Investigational Site | Rosario | |
| Argentina | 205.452.54021 Boehringer Ingelheim Investigational Site | Rosario | |
| Argentina | 205.452.54017 Boehringer Ingelheim Investigational Site | San Miguel de Tucumán | |
| Argentina | 205.452.54023 Boehringer Ingelheim Investigational Site | San Miguel de Tucumán | |
| Australia | 205.452.61006 Boehringer Ingelheim Investigational Site | Adelaide | South Australia |
| Australia | 205.452.61004 Boehringer Ingelheim Investigational Site | Box Hill | Victoria |
| Australia | 205.452.61003 Boehringer Ingelheim Investigational Site | Footscray | Victoria |
| Australia | 205.452.61001 Boehringer Ingelheim Investigational Site | Frankston | Victoria |
| Australia | 205.452.61005 Boehringer Ingelheim Investigational Site | Nedlands | Western Australia |
| Australia | 205.452.61002 Boehringer Ingelheim Investigational Site | Woodville | South Australia |
| Austria | 205.452.43002 Boehringer Ingelheim Investigational Site | Feldbach | |
| Austria | 205.452.43003 Boehringer Ingelheim Investigational Site | Hallein | |
| Austria | 205.452.43005 Boehringer Ingelheim Investigational Site | Thalheim bei Wels | |
| Belgium | 205.452.32009 Boehringer Ingelheim Investigational Site | Godinne | |
| Belgium | 205.452.32007 Boehringer Ingelheim Investigational Site | Gozée | |
| Belgium | 205.452.32002 Boehringer Ingelheim Investigational Site | Halen | |
| Belgium | 205.452.32001 Boehringer Ingelheim Investigational Site | Leuven | |
| Belgium | 205.452.32006 Boehringer Ingelheim Investigational Site | Linkebeek | |
| Belgium | 205.452.32005 Boehringer Ingelheim Investigational Site | Merksem | |
| Belgium | 205.452.32008 Boehringer Ingelheim Investigational Site | Natoye | |
| Belgium | 205.452.32003 Boehringer Ingelheim Investigational Site | Tessenderlo | |
| Belgium | 205.452.32004 Boehringer Ingelheim Investigational Site | Zichem | |
| Brazil | 205.452.55005 Boehringer Ingelheim Investigational Site | Florianópolis | |
| Brazil | 205.452.55010 Boehringer Ingelheim Investigational Site | Passo Fundo - RS | |
| Brazil | 205.452.55001 Boehringer Ingelheim Investigational Site | Porto Alegre | |
| Brazil | 205.452.55002 Boehringer Ingelheim Investigational Site | Porto Alegre | |
| Brazil | 205.452.55003 Boehringer Ingelheim Investigational Site | Recife | |
| Brazil | 205.452.55004 Boehringer Ingelheim Investigational Site | Rio de Janeiro | |
| Brazil | 205.452.55011 Boehringer Ingelheim Investigational Site | Río de Janeiro | |
| Brazil | 205.452.55008 Boehringer Ingelheim Investigational Site | Sao Pablo | |
| Brazil | 205.452.55009 Boehringer Ingelheim Investigational Site | Sao Paulo | |
| Brazil | 205.452.55006 Boehringer Ingelheim Investigational Site | São Paulo | |
| Brazil | 205.452.55007 Boehringer Ingelheim Investigational Site | São Paulo | |
| Bulgaria | 205.452.35909 Boehringer Ingelheim Investigational Site | Plovdiv | |
| Bulgaria | 205.452.35910 Boehringer Ingelheim Investigational Site | Plovdiv | |
| Bulgaria | 205.452.35901 Boehringer Ingelheim Investigational Site | Sofia | |
| Bulgaria | 205.452.35902 Boehringer Ingelheim Investigational Site | Sofia | |
| Bulgaria | 205.452.35903 Boehringer Ingelheim Investigational Site | Sofia | |
| Bulgaria | 205.452.35904 Boehringer Ingelheim Investigational Site | Sofia | |
| Bulgaria | 205.452.35905 Boehringer Ingelheim Investigational Site | Sofia | |
| Bulgaria | 205.452.35908 Boehringer Ingelheim Investigational Site | Sofia | |
| Bulgaria | 205.452.35914 Boehringer Ingelheim Investigational Site | Sofia | |
| Bulgaria | 205.452.35915 Boehringer Ingelheim Investigational Site | Sofia | |
| Bulgaria | 205.452.35912 Boehringer Ingelheim Investigational Site | Stara Zagora | |
| Bulgaria | 205.452.35906 Boehringer Ingelheim Investigational Site | Veliko Turnovo | |
| Canada | 205.452.11030 Boehringer Ingelheim Investigational Site | Burlington | Ontario |
| Canada | 205.452.11015 Boehringer Ingelheim Investigational Site | Calgary | Alberta |
| Canada | 205.452.11032 Boehringer Ingelheim Investigational Site | Calgary | Alberta |
| Canada | 205.452.11042 Boehringer Ingelheim Investigational Site | Corunna | Ontario |
| Canada | 205.452.11049 Boehringer Ingelheim Investigational Site | Courtice | Ontario |
| Canada | 205.452.11004 Boehringer Ingelheim Investigational Site | Downsview | Ontario |
| Canada | 205.452.11028 Boehringer Ingelheim Investigational Site | Edmonton | Alberta |
| Canada | 205.452.11037 Boehringer Ingelheim Investigational Site | Edmonton | Alberta |
| Canada | 205.452.11045 Boehringer Ingelheim Investigational Site | Edmonton | Alberta |
| Canada | 205.452.11047 Boehringer Ingelheim Investigational Site | Edmonton | Alberta |
| Canada | 205.452.11044 Boehringer Ingelheim Investigational Site | Grand Falls-Windsor | Newfoundland and Labrador |
| Canada | 205.452.11007 Boehringer Ingelheim Investigational Site | Greenfield Park | Quebec |
| Canada | 205.452.11009 Boehringer Ingelheim Investigational Site | Hamilton | Ontario |
| Canada | 205.452.11029 Boehringer Ingelheim Investigational Site | Hamilton | Ontario |
| Canada | 205.452.11050 Boehringer Ingelheim Investigational Site | Hamilton | Ontario |
| Canada | 205.452.11048 Boehringer Ingelheim Investigational Site | Kelowna | British Columbia |
| Canada | 205.452.11040 Boehringer Ingelheim Investigational Site | Kingston | Ontario |
| Canada | 205.452.11005 Boehringer Ingelheim Investigational Site | La Malbaie | Quebec |
| Canada | 205.452.11035 Boehringer Ingelheim Investigational Site | London | Ontario |
| Canada | 205.452.11006 Boehringer Ingelheim Investigational Site | Longueuil | Quebec |
| Canada | 205.452.11051 Boehringer Ingelheim Investigational Site | Maple Ridge | British Columbia |
| Canada | 205.452.11001 Boehringer Ingelheim Investigational Site | Mississauga | Ontario |
| Canada | 205.452.11054 Boehringer Ingelheim Investigational Site | Mississauga | Ontario |
| Canada | 205.452.11033 Boehringer Ingelheim Investigational Site | Moncton | New Brunswick |
| Canada | 205.452.11043 Boehringer Ingelheim Investigational Site | Montreal | Quebec |
| Canada | 205.452.11053 Boehringer Ingelheim Investigational Site | Mount Pearl | Newfoundland and Labrador |
| Canada | 205.452.11022 Boehringer Ingelheim Investigational Site | Newmarket | Ontario |
| Canada | 205.452.11024 Boehringer Ingelheim Investigational Site | Ottawa | Ontario |
| Canada | 205.452.11013 Boehringer Ingelheim Investigational Site | Point Claire | Quebec |
| Canada | 205.452.11031 Boehringer Ingelheim Investigational Site | Quebec | |
| Canada | 205.452.11027 Boehringer Ingelheim Investigational Site | Richmond Hill | Ontario |
| Canada | 205.452.11010 Boehringer Ingelheim Investigational Site | Saint John | New Brunswick |
| Canada | 205.452.11041 Boehringer Ingelheim Investigational Site | Sarnia | Ontario |
| Canada | 205.452.11003 Boehringer Ingelheim Investigational Site | Saskatoon | Saskatchewan |
| Canada | 205.452.11011 Boehringer Ingelheim Investigational Site | Saskatoon | Saskatchewan |
| Canada | 205.452.11036 Boehringer Ingelheim Investigational Site | Saskatoon | Saskatchewan |
| Canada | 205.452.11039 Boehringer Ingelheim Investigational Site | Saskatoon | Saskatchewan |
| Canada | 205.452.11018 Boehringer Ingelheim Investigational Site | Sherbrooke | Quebec |
| Canada | 205.452.11002 Boehringer Ingelheim Investigational Site | Spruce Grove | Alberta |
| Canada | 205.452.11017 Boehringer Ingelheim Investigational Site | St. John's | Newfoundland and Labrador |
| Canada | 205.452.11021 Boehringer Ingelheim Investigational Site | St. John's | Newfoundland and Labrador |
| Canada | 205.452.11020 Boehringer Ingelheim Investigational Site | St. Lambert | Quebec |
| Canada | 205.452.11019 Boehringer Ingelheim Investigational Site | Toronto | Ontario |
| Canada | 205.452.11034 Boehringer Ingelheim Investigational Site | Toronto | Ontario |
| Canada | 205.452.11052 Boehringer Ingelheim Investigational Site | Toronto | Ontario |
| Canada | 205.452.11026 Boehringer Ingelheim Investigational Site | Trois-Rivieres | Quebec |
| Canada | 205.452.11014 Boehringer Ingelheim Investigational Site | Vancouver | British Columbia |
| Canada | 205.452.11016 Boehringer Ingelheim Investigational Site | Vancouver | British Columbia |
| Canada | 205.452.11012 Boehringer Ingelheim Investigational Site | Windsor | Ontario |
| Canada | 205.452.11025 Boehringer Ingelheim Investigational Site | Winnipeg | Manitoba |
| China | 205.452.86009 Boehringer Ingelheim Investigational Site | Beijing | |
| China | 205.452.86010 Boehringer Ingelheim Investigational Site | Beijing | |
| China | 205.452.86011 Boehringer Ingelheim Investigational Site | Beijing | |
| China | 205.452.86012 Boehringer Ingelheim Investigational Site | Beijing | |
| China | 205.452.86038 Boehringer Ingelheim Investigational Site | Beijing | |
| China | 205.452.86026 Boehringer Ingelheim Investigational Site | Changchun | |
| China | 205.452.86024 Boehringer Ingelheim Investigational Site | Changsha | |
| China | 205.452.86025 Boehringer Ingelheim Investigational Site | Changsha | |
| China | 205.452.86021 Boehringer Ingelheim Investigational Site | Chengdu | |
| China | 205.452.86032 Boehringer Ingelheim Investigational Site | Chengdu | |
| China | 205.452.86034 Boehringer Ingelheim Investigational Site | Chongqing | |
| China | 205.452.86035 Boehringer Ingelheim Investigational Site | Chongqing | |
| China | 205.452.86036 Boehringer Ingelheim Investigational Site | Chongqing | |
| China | 205.452.86020 Boehringer Ingelheim Investigational Site | Foshan | |
| China | 205.452.86001 Boehringer Ingelheim Investigational Site | Guangzhou | |
| China | 205.452.86004 Boehringer Ingelheim Investigational Site | Guangzhou | |
| China | 205.452.86005 Boehringer Ingelheim Investigational Site | Guangzhou | |
| China | 205.452.86019 Boehringer Ingelheim Investigational Site | Guangzhou | |
| China | 205.452.86028 Boehringer Ingelheim Investigational Site | Guangzhou | |
| China | 205.452.86030 Boehringer Ingelheim Investigational Site | Haikou | |
| China | 205.452.86007 Boehringer Ingelheim Investigational Site | Hangzhou | |
| China | 205.452.86008 Boehringer Ingelheim Investigational Site | Hangzhou | |
| China | 205.452.86029 Boehringer Ingelheim Investigational Site | Nan Ning | |
| China | 205.452.86037 Boehringer Ingelheim Investigational Site | Nanchang | |
| China | 205.452.86022 Boehringer Ingelheim Investigational Site | Nanjing | |
| China | 205.452.86027 Boehringer Ingelheim Investigational Site | Qingdao | |
| China | 205.452.86002 Boehringer Ingelheim Investigational Site | Shanghai | |
| China | 205.452.86003 Boehringer Ingelheim Investigational Site | Shanghai | |
| China | 205.452.86018 Boehringer Ingelheim Investigational Site | Shanghai | |
| China | 205.452.86014 Boehringer Ingelheim Investigational Site | Shenyang | |
| China | 205.452.86015 Boehringer Ingelheim Investigational Site | Shenyang | |
| China | 205.452.86006 Boehringer Ingelheim Investigational Site | Suzhou | |
| China | 205.452.86033 Boehringer Ingelheim Investigational Site | Tianjin | |
| China | 205.452.86031 Boehringer Ingelheim Investigational Site | Wuhan | |
| China | 205.452.86016 Boehringer Ingelheim Investigational Site | Xi'An | |
| China | 205.452.86017 Boehringer Ingelheim Investigational Site | Xi'An | |
| Colombia | 205.452.57002 Boehringer Ingelheim Investigational Site | Bogotá | |
| Colombia | 205.452.57004 Boehringer Ingelheim Investigational Site | Bogotá | |
| Colombia | 205.452.57005 Boehringer Ingelheim Investigational Site | Bogotá | |
| Colombia | 205.452.57006 Boehringer Ingelheim Investigational Site | Bogotá | |
| Colombia | 205.452.57001 Boehringer Ingelheim Investigational Site | Medellín | |
| Croatia | 205.452.38512 Boehringer Ingelheim Investigational Site | Cakovec | |
| Croatia | 205.452.38508 Boehringer Ingelheim Investigational Site | Dubrovnik | |
| Croatia | 205.452.38510 Boehringer Ingelheim Investigational Site | Osijek | |
| Croatia | 205.452.38501 Boehringer Ingelheim Investigational Site | Rijeka | |
| Croatia | 205.452.38506 Boehringer Ingelheim Investigational Site | Sisak | |
| Croatia | 205.452.38502 Boehringer Ingelheim Investigational Site | Split | |
| Croatia | 205.452.38503 Boehringer Ingelheim Investigational Site | Split | |
| Croatia | 205.452.38504 Boehringer Ingelheim Investigational Site | Zagreb | |
| Croatia | 205.452.38505 Boehringer Ingelheim Investigational Site | Zagreb | |
| Croatia | 205.452.38507 Boehringer Ingelheim Investigational Site | Zagreb | |
| Croatia | 205.452.38509 Boehringer Ingelheim Investigational Site | Zagreb | |
| Croatia | 205.452.38511 Boehringer Ingelheim Investigational Site | Zagreb | |
| Denmark | 205.452.45002 Boehringer Ingelheim Investigational Site | Aalborg | |
| Denmark | 205.452.45003 Boehringer Ingelheim Investigational Site | Aarhus C | |
| Denmark | 205.452.45006 Boehringer Ingelheim Investigational Site | Birkerød | |
| Denmark | 205.452.45001 Boehringer Ingelheim Investigational Site | København NV | |
| Denmark | 205.452.45005 Boehringer Ingelheim Investigational Site | København S | |
| Denmark | 205.452.45013 Boehringer Ingelheim Investigational Site | Kolding | |
| Denmark | 205.452.45012 Boehringer Ingelheim Investigational Site | Odense C | |
| Denmark | 205.452.45009 Boehringer Ingelheim Investigational Site | Rødovre | |
| Denmark | 205.452.45010 Boehringer Ingelheim Investigational Site | Rødovre | |
| Denmark | 205.452.45016 Boehringer Ingelheim Investigational Site | Roskilde | |
| Denmark | 205.452.45004 Boehringer Ingelheim Investigational Site | Silkeborg | |
| Denmark | 205.452.45014 Boehringer Ingelheim Investigational Site | Skive | |
| Denmark | 205.452.45011 Boehringer Ingelheim Investigational Site | Sønderborg | |
| Denmark | 205.452.45007 Boehringer Ingelheim Investigational Site | Værløse | |
| Denmark | 205.452.45015 Boehringer Ingelheim Investigational Site | Viby | |
| Finland | 205.452.35801 Boehringer Ingelheim Investigational Site | Helsinki | |
| Finland | 205.452.35804 Boehringer Ingelheim Investigational Site | Lahti | |
| Finland | 205.452.35808 Boehringer Ingelheim Investigational Site | Pori | |
| Finland | 205.452.35805 Boehringer Ingelheim Investigational Site | Porvoo | |
| Finland | 205.452.35806 Boehringer Ingelheim Investigational Site | Tammisaari | |
| Finland | 205.452.35802 Boehringer Ingelheim Investigational Site | Tampere | |
| Finland | 205.452.35803 Boehringer Ingelheim Investigational Site | Turku | |
| France | 205.452.33087 Boehringer Ingelheim Investigational Site | Albens | |
| France | 205.452.33028 Boehringer Ingelheim Investigational Site | Angers | |
| France | 205.452.33055 Boehringer Ingelheim Investigational Site | Angers | |
| France | 205.452.33142 Boehringer Ingelheim Investigational Site | Angers | |
| France | 205.452.33159 Boehringer Ingelheim Investigational Site | Angers | |
| France | 205.452.33030 Boehringer Ingelheim Investigational Site | Anzin | |
| France | 205.452.33158 Boehringer Ingelheim Investigational Site | Arras | |
| France | 205.452.33084 Boehringer Ingelheim Investigational Site | Avrillé | |
| France | 205.452.33128 Boehringer Ingelheim Investigational Site | Becon les Granits | |
| France | 205.452.33029 Boehringer Ingelheim Investigational Site | Bersée | |
| France | 205.452.33018 Boehringer Ingelheim Investigational Site | Beziers | |
| France | 205.452.33053 Boehringer Ingelheim Investigational Site | Bischheim | |
| France | 205.452.33024 Boehringer Ingelheim Investigational Site | Blois | |
| France | 205.452.33043 Boehringer Ingelheim Investigational Site | Bort les Orgues | |
| France | 205.452.33091 Boehringer Ingelheim Investigational Site | Bourg des cptes | |
| France | 205.452.33123 Boehringer Ingelheim Investigational Site | Briollay | |
| France | 205.452.33063 Boehringer Ingelheim Investigational Site | Broglie | |
| France | 205.452.33074 Boehringer Ingelheim Investigational Site | Bruay La Buissiere | |
| France | 205.452.33118 Boehringer Ingelheim Investigational Site | Cannes | |
| France | 205.452.33010 Boehringer Ingelheim Investigational Site | Cannes Cedex | |
| France | 205.452.33009 Boehringer Ingelheim Investigational Site | Chamalières | |
| France | 205.452.33073 Boehringer Ingelheim Investigational Site | Chambery | |
| France | 205.452.33059 Boehringer Ingelheim Investigational Site | Chateau Renault | |
| France | 205.452.33089 Boehringer Ingelheim Investigational Site | Colombey les Belles | |
| France | 205.452.33099 Boehringer Ingelheim Investigational Site | Cournonterral | |
| France | 205.452.33127 Boehringer Ingelheim Investigational Site | Cournonterral | |
| France | 205.452.33162 Boehringer Ingelheim Investigational Site | Croix | |
| France | 205.452.33105 Boehringer Ingelheim Investigational Site | Dinard | |
| France | 205.452.33110 Boehringer Ingelheim Investigational Site | Donges | |
| France | 205.452.33094 Boehringer Ingelheim Investigational Site | Gambsheim | |
| France | 205.452.33046 Boehringer Ingelheim Investigational Site | Grenoble | |
| France | 205.452.33096 Boehringer Ingelheim Investigational Site | Hautmont | |
| France | 205.452.33090 Boehringer Ingelheim Investigational Site | Hinx | |
| France | 205.452.33145 Boehringer Ingelheim Investigational Site | Jarny | |
| France | 205.452.33154 Boehringer Ingelheim Investigational Site | La Bouëxière | |
| France | 205.452.33065 Boehringer Ingelheim Investigational Site | La Chapelle sur Erdre | |
| France | 205.452.33102 Boehringer Ingelheim Investigational Site | La Montagne | |
| France | 205.452.33100 Boehringer Ingelheim Investigational Site | La Riche | |
| France | 205.452.33058 Boehringer Ingelheim Investigational Site | Lambersart | |
| France | 205.452.33098 Boehringer Ingelheim Investigational Site | Lambersart | |
| France | 205.452.33103 Boehringer Ingelheim Investigational Site | Levallois Perret | |
| France | 205.452.33164 Boehringer Ingelheim Investigational Site | Louvigne De bais | |
| France | 205.452.33111 Boehringer Ingelheim Investigational Site | Luynes | |
| France | 205.452.33136 Boehringer Ingelheim Investigational Site | Marcq en Baroeul | |
| France | 205.452.33115 Boehringer Ingelheim Investigational Site | Mondelange | |
| France | 205.452.33088 Boehringer Ingelheim Investigational Site | Mont de Marsan | |
| France | 205.452.33138 Boehringer Ingelheim Investigational Site | Mont de Marsan | |
| France | 205.452.33005 Boehringer Ingelheim Investigational Site | Montigny les Metz | |
| France | 205.452.33163 Boehringer Ingelheim Investigational Site | Mundolsheim | |
| France | 205.452.33109 Boehringer Ingelheim Investigational Site | Murs Erigne | |
| France | 205.452.33031 Boehringer Ingelheim Investigational Site | Nantes | |
| France | 205.452.33003 Boehringer Ingelheim Investigational Site | Nice | |
| France | 205.452.33108 Boehringer Ingelheim Investigational Site | Oignies | |
| France | 205.452.33014 Boehringer Ingelheim Investigational Site | Ollioules | |
| France | 205.452.33157 Boehringer Ingelheim Investigational Site | Orthez | |
| France | 205.452.33112 Boehringer Ingelheim Investigational Site | Parcay les Pins | |
| France | 205.452.33001 Boehringer Ingelheim Investigational Site | Paris | |
| France | 205.452.33051 Boehringer Ingelheim Investigational Site | Paris | |
| France | 205.452.33082 Boehringer Ingelheim Investigational Site | Paris | |
| France | 205.452.33165 Boehringer Ingelheim Investigational Site | Paris | |
| France | 205.452.33130 Boehringer Ingelheim Investigational Site | Pont à Mousson | |
| France | 205.452.33122 Boehringer Ingelheim Investigational Site | Quarouble | |
| France | 205.452.33006 Boehringer Ingelheim Investigational Site | Reims | |
| France | 205.452.33153 Boehringer Ingelheim Investigational Site | Rosiers d'Egletons | |
| France | 205.452.33161 Boehringer Ingelheim Investigational Site | Rugles | |
| France | 205.452.33126 Boehringer Ingelheim Investigational Site | Saint Alban Leysse | |
| France | 205.452.33140 Boehringer Ingelheim Investigational Site | Saint Aulaire | |
| France | 205.452.33052 Boehringer Ingelheim Investigational Site | Saint Avertin | |
| France | 205.452.33011 Boehringer Ingelheim Investigational Site | Saint Léger des Bois | |
| France | 205.452.33002 Boehringer Ingelheim Investigational Site | Saintes | |
| France | 205.452.33148 Boehringer Ingelheim Investigational Site | Salies de Bearn | |
| France | 205.452.33026 Boehringer Ingelheim Investigational Site | Savonnières | |
| France | 205.452.33067 Boehringer Ingelheim Investigational Site | Segre | |
| France | 205.452.33040 Boehringer Ingelheim Investigational Site | Serres Casset | |
| France | 205.452.33012 Boehringer Ingelheim Investigational Site | Six Four les Plages | |
| France | 205.452.33160 Boehringer Ingelheim Investigational Site | St Jouan des Guerets | |
| France | 205.452.33079 Boehringer Ingelheim Investigational Site | St Sebastien sur Loire | |
| France | 205.452.33007 Boehringer Ingelheim Investigational Site | Strasbourg | |
| France | 205.452.33033 Boehringer Ingelheim Investigational Site | Strasbourg | |
| France | 205.452.33097 Boehringer Ingelheim Investigational Site | Strasbourg | |
| France | 205.452.33101 Boehringer Ingelheim Investigational Site | Strasbourg | |
| France | 205.452.33107 Boehringer Ingelheim Investigational Site | Thouars | |
| France | 205.452.33116 Boehringer Ingelheim Investigational Site | Tinténiac | |
| France | 205.452.33013 Boehringer Ingelheim Investigational Site | Toulon | |
| France | 205.452.33054 Boehringer Ingelheim Investigational Site | Tours | |
| France | 205.452.33064 Boehringer Ingelheim Investigational Site | Tours | |
| France | 205.452.33092 Boehringer Ingelheim Investigational Site | Tours | |
| France | 205.452.33124 Boehringer Ingelheim Investigational Site | Tours | |
| France | 205.452.33066 Boehringer Ingelheim Investigational Site | Vendôme | |
| France | 205.452.33137 Boehringer Ingelheim Investigational Site | Vernoil | |
| France | 205.452.33032 Boehringer Ingelheim Investigational Site | Vieux Condé | |
| France | 205.452.33151 Boehringer Ingelheim Investigational Site | Vihiers | |
| France | 205.452.33077 Boehringer Ingelheim Investigational Site | Villey St Etienne | |
| France | 205.452.33135 Boehringer Ingelheim Investigational Site | Wattrelos | |
| Georgia | 205.452.99501 Boehringer Ingelheim Investigational Site | Tbilisi | |
| Georgia | 205.452.99502 Boehringer Ingelheim Investigational Site | Tbilisi | |
| Georgia | 205.452.99503 Boehringer Ingelheim Investigational Site | Tbilisi | |
| Georgia | 205.452.99504 Boehringer Ingelheim Investigational Site | Tbilisi | |
| Georgia | 205.452.99505 Boehringer Ingelheim Investigational Site | Tbilisi | |
| Georgia | 205.452.99506 Boehringer Ingelheim Investigational Site | Tbilisi | |
| Georgia | 205.452.99507 Boehringer Ingelheim Investigational Site | Tbilisi | |
| Germany | 205.452.49096 Boehringer Ingelheim Investigational Site | Aschaffenburg | |
| Germany | 205.452.49130 Boehringer Ingelheim Investigational Site | Augsburg | |
| Germany | 205.452.49161 Boehringer Ingelheim Investigational Site | Augsburg | |
| Germany | 205.452.49001 Boehringer Ingelheim Investigational Site | Backnang | |
| Germany | 205.452.49173 Boehringer Ingelheim Investigational Site | Bad Kissingen | |
| Germany | 205.452.49134 Boehringer Ingelheim Investigational Site | Bad Lippspringe | |
| Germany | 205.452.49082 Boehringer Ingelheim Investigational Site | Bad Neustadt | |
| Germany | 205.452.49058 Boehringer Ingelheim Investigational Site | Bad Wörishofen | |
| Germany | 205.452.49145 Boehringer Ingelheim Investigational Site | Bamberg | |
| Germany | 205.452.49072 Boehringer Ingelheim Investigational Site | Bensheim | |
| Germany | 205.452.49048 Boehringer Ingelheim Investigational Site | Bergisch Gladbach | |
| Germany | 205.452.49006 Boehringer Ingelheim Investigational Site | Berlin | |
| Germany | 205.452.49016 Boehringer Ingelheim Investigational Site | Berlin | |
| Germany | 205.452.49028 Boehringer Ingelheim Investigational Site | Berlin | |
| Germany | 205.452.49031 Boehringer Ingelheim Investigational Site | Berlin | |
| Germany | 205.452.49054 Boehringer Ingelheim Investigational Site | Berlin | |
| Germany | 205.452.49064 Boehringer Ingelheim Investigational Site | Berlin | |
| Germany | 205.452.49066 Boehringer Ingelheim Investigational Site | Berlin | |
| Germany | 205.452.49068 Boehringer Ingelheim Investigational Site | Berlin | |
| Germany | 205.452.49102 Boehringer Ingelheim Investigational Site | Berlin | |
| Germany | 205.452.49135 Boehringer Ingelheim Investigational Site | Berlin | |
| Germany | 205.452.49138 Boehringer Ingelheim Investigational Site | Berlin | |
| Germany | 205.452.49157 Boehringer Ingelheim Investigational Site | Berlin | |
| Germany | 205.452.49167 Boehringer Ingelheim Investigational Site | Berlin | |
| Germany | 205.452.49175 Boehringer Ingelheim Investigational Site | Berlin | |
| Germany | 205.452.49180 Boehringer Ingelheim Investigational Site | Berlin | |
| Germany | 205.452.49037 Boehringer Ingelheim Investigational Site | Bonn | |
| Germany | 205.452.49118 Boehringer Ingelheim Investigational Site | Bonn | |
| Germany | 205.452.49083 Boehringer Ingelheim Investigational Site | Brake | |
| Germany | 205.452.49040 Boehringer Ingelheim Investigational Site | Bruchsal | |
| Germany | 205.452.49089 Boehringer Ingelheim Investigational Site | Celle | |
| Germany | 205.452.49143 Boehringer Ingelheim Investigational Site | Cottbus | |
| Germany | 205.452.49119 Boehringer Ingelheim Investigational Site | Deggendorf | |
| Germany | 205.452.49151 Boehringer Ingelheim Investigational Site | Dillingen | |
| Germany | 205.452.49117 Boehringer Ingelheim Investigational Site | Donaueschingen | |
| Germany | 205.452.49015 Boehringer Ingelheim Investigational Site | Dortmund | |
| Germany | 205.452.49008 Boehringer Ingelheim Investigational Site | Düren | |
| Germany | 205.452.49098 Boehringer Ingelheim Investigational Site | Emden | |
| Germany | 205.452.49003 Boehringer Ingelheim Investigational Site | Engelskirchen | |
| Germany | 205.452.49024 Boehringer Ingelheim Investigational Site | Ense | |
| Germany | 205.452.49168 Boehringer Ingelheim Investigational Site | Essen | |
| Germany | 205.452.49133 Boehringer Ingelheim Investigational Site | Föhren | |
| Germany | 205.452.49104 Boehringer Ingelheim Investigational Site | Forchheim | |
| Germany | 205.452.49070 Boehringer Ingelheim Investigational Site | Frankfurt | |
| Germany | 205.452.49147 Boehringer Ingelheim Investigational Site | Frankfurt | |
| Germany | 205.452.49137 Boehringer Ingelheim Investigational Site | Fulda | |
| Germany | 205.452.49107 Boehringer Ingelheim Investigational Site | Gelnhausen | |
| Germany | 205.452.49032 Boehringer Ingelheim Investigational Site | Gütersloh | |
| Germany | 205.452.49026 Boehringer Ingelheim Investigational Site | Hagen | |
| Germany | 205.452.49041 Boehringer Ingelheim Investigational Site | Hagen | |
| Germany | 205.452.49044 Boehringer Ingelheim Investigational Site | Hamburg | |
| Germany | 205.452.49061 Boehringer Ingelheim Investigational Site | Hamburg | |
| Germany | 205.452.49080 Boehringer Ingelheim Investigational Site | Hamburg | |
| Germany | 205.452.49038 Boehringer Ingelheim Investigational Site | Hannover | |
| Germany | 205.452.49052 Boehringer Ingelheim Investigational Site | Hannover | |
| Germany | 205.452.49094 Boehringer Ingelheim Investigational Site | Hannover | |
| Germany | 205.452.49181 Boehringer Ingelheim Investigational Site | Heidelberg | |
| Germany | 205.452.49116 Boehringer Ingelheim Investigational Site | Heilbronn | |
| Germany | 205.452.49022 Boehringer Ingelheim Investigational Site | Hemmingen | |
| Germany | 205.452.49007 Boehringer Ingelheim Investigational Site | Höchstädt | |
| Germany | 205.452.49136 Boehringer Ingelheim Investigational Site | Ingelheim | |
| Germany | 205.452.49047 Boehringer Ingelheim Investigational Site | Käbschütztal-Krögis | |
| Germany | 205.452.49159 Boehringer Ingelheim Investigational Site | Karlsruhe | |
| Germany | 205.452.49027 Boehringer Ingelheim Investigational Site | Kassel | |
| Germany | 205.452.49105 Boehringer Ingelheim Investigational Site | Kaufbeuren | |
| Germany | 205.452.49101 Boehringer Ingelheim Investigational Site | Koblenz | |
| Germany | 205.452.49146 Boehringer Ingelheim Investigational Site | Köln | |
| Germany | 205.452.49114 Boehringer Ingelheim Investigational Site | Landsberg am Lech | |
| Germany | 205.452.49169 Boehringer Ingelheim Investigational Site | Langen | |
| Germany | 205.452.49017 Boehringer Ingelheim Investigational Site | Leipzig | |
| Germany | 205.452.49035 Boehringer Ingelheim Investigational Site | Leipzig | |
| Germany | 205.452.49113 Boehringer Ingelheim Investigational Site | Leipzig | |
| Germany | 205.452.49139 Boehringer Ingelheim Investigational Site | Leipzig | |
| Germany | 205.452.49172 Boehringer Ingelheim Investigational Site | Leipzig | |
| Germany | 205.452.49110 Boehringer Ingelheim Investigational Site | Leonberg | |
| Germany | 205.452.49088 Boehringer Ingelheim Investigational Site | Mannheim | |
| Germany | 205.452.49108 Boehringer Ingelheim Investigational Site | Marburg | |
| Germany | 205.452.49122 Boehringer Ingelheim Investigational Site | Marburg | |
| Germany | 205.452.49055 Boehringer Ingelheim Investigational Site | Minden | |
| Germany | 205.452.49025 Boehringer Ingelheim Investigational Site | München | |
| Germany | 205.452.49131 Boehringer Ingelheim Investigational Site | München | |
| Germany | 205.452.49023 Boehringer Ingelheim Investigational Site | Neumünster | |
| Germany | 205.452.49132 Boehringer Ingelheim Investigational Site | Neuruppin | |
| Germany | 205.452.49045 Boehringer Ingelheim Investigational Site | Neuwied | |
| Germany | 205.452.49062 Boehringer Ingelheim Investigational Site | Oranienburg | |
| Germany | 205.452.49124 Boehringer Ingelheim Investigational Site | Oschersleben | |
| Germany | 205.452.49019 Boehringer Ingelheim Investigational Site | Paderborn | |
| Germany | 205.452.49053 Boehringer Ingelheim Investigational Site | Potsdam | |
| Germany | 205.452.49076 Boehringer Ingelheim Investigational Site | Potsdam | |
| Germany | 205.452.49049 Boehringer Ingelheim Investigational Site | Radebeul | |
| Germany | 205.452.49056 Boehringer Ingelheim Investigational Site | Rathenow | |
| Germany | 205.452.49009 Boehringer Ingelheim Investigational Site | Raubach | |
| Germany | 205.452.49002 Boehringer Ingelheim Investigational Site | Rehau | |
| Germany | 205.452.49142 Boehringer Ingelheim Investigational Site | Reinfeld | |
| Germany | 205.452.49030 Boehringer Ingelheim Investigational Site | Rhaunen | |
| Germany | 205.452.49184 Boehringer Ingelheim Investigational Site | Rheine | |
| Germany | 205.452.49077 Boehringer Ingelheim Investigational Site | Rodgau-Dudenhofen | |
| Germany | 205.452.49021 Boehringer Ingelheim Investigational Site | Rüsselsheim | |
| Germany | 205.452.49091 Boehringer Ingelheim Investigational Site | Rüsselsheim | |
| Germany | 205.452.49042 Boehringer Ingelheim Investigational Site | Saarlouis | |
| Germany | 205.452.49034 Boehringer Ingelheim Investigational Site | Schwetzingen | |
| Germany | 205.452.49013 Boehringer Ingelheim Investigational Site | Solingen | |
| Germany | 205.452.49057 Boehringer Ingelheim Investigational Site | Solingen | |
| Germany | 205.452.49078 Boehringer Ingelheim Investigational Site | Tübingen | |
| Germany | 205.452.49099 Boehringer Ingelheim Investigational Site | Ulm | |
| Germany | 205.452.49043 Boehringer Ingelheim Investigational Site | Wallerfing | |
| Germany | 205.452.49067 Boehringer Ingelheim Investigational Site | Wardenburg | |
| Germany | 205.452.49165 Boehringer Ingelheim Investigational Site | Warendorf | |
| Germany | 205.452.49051 Boehringer Ingelheim Investigational Site | Weinheim | |
| Germany | 205.452.49127 Boehringer Ingelheim Investigational Site | Weyhe | |
| Germany | 205.452.49092 Boehringer Ingelheim Investigational Site | Wiesloch | |
| Germany | 205.452.49018 Boehringer Ingelheim Investigational Site | Witten | |
| Germany | 205.452.49029 Boehringer Ingelheim Investigational Site | Witten | |
| Germany | 205.452.49095 Boehringer Ingelheim Investigational Site | Wolfsburg | |
| Germany | 205.452.49060 Boehringer Ingelheim Investigational Site | Zerbst | |
| Greece | 205.452.30002 Boehringer Ingelheim Investigational Site | Athens | |
| Greece | 205.452.30003 Boehringer Ingelheim Investigational Site | Athens | |
| Greece | 205.452.30008 Boehringer Ingelheim Investigational Site | Athens | |
| Greece | 205.452.30001 Boehringer Ingelheim Investigational Site | Heraklion | |
| Greece | 205.452.30007 Boehringer Ingelheim Investigational Site | Kalamaria | |
| Greece | 205.452.30010 Boehringer Ingelheim Investigational Site | Kavala | |
| Greece | 205.452.30012 Boehringer Ingelheim Investigational Site | Lamia | |
| Greece | 205.452.30005 Boehringer Ingelheim Investigational Site | Nafplio | |
| Greece | 205.452.30011 Boehringer Ingelheim Investigational Site | Rethymno | |
| Greece | 205.452.30006 Boehringer Ingelheim Investigational Site | Serres | |
| Greece | 205.452.30004 Boehringer Ingelheim Investigational Site | Thessaloniki | |
| Greece | 205.452.30009 Boehringer Ingelheim Investigational Site | Thessaloniki | |
| Guatemala | 205.452.50205 Boehringer Ingelheim Investigational Site | Guatemala | |
| Guatemala | 205.452.50206 Boehringer Ingelheim Investigational Site | Guatemala | |
| Guatemala | 205.452.50203 Boehringer Ingelheim Investigational Site | Nivel 12 | |
| Guatemala | 205.452.50201 Boehringer Ingelheim Investigational Site | Nivel Guatemala | |
| Guatemala | 205.452.50202 Boehringer Ingelheim Investigational Site | Nivel Guatemala | |
| Guatemala | 205.452.50204 Boehringer Ingelheim Investigational Site | Nivel Guatemala | |
| Guatemala | 205.452.50207 Boehringer Ingelheim Investigational Site | Quetzaltenango | |
| Hungary | 205.452.36005 Boehringer Ingelheim Investigational Site | Baja | |
| Hungary | 205.452.36004 Boehringer Ingelheim Investigational Site | Budapest | |
| Hungary | 205.452.36016 Boehringer Ingelheim Investigational Site | Budapest | |
| Hungary | 205.452.36030 Boehringer Ingelheim Investigational Site | Budapest | |
| Hungary | 205.452.36007 Boehringer Ingelheim Investigational Site | Debrecen | |
| Hungary | 205.452.36013 Boehringer Ingelheim Investigational Site | Debrecen | |
| Hungary | 205.452.36015 Boehringer Ingelheim Investigational Site | Debrecen | |
| Hungary | 205.452.36029 Boehringer Ingelheim Investigational Site | Deszk | |
| Hungary | 205.452.36026 Boehringer Ingelheim Investigational Site | Dombovar | |
| Hungary | 205.452.36003 Boehringer Ingelheim Investigational Site | Erd | |
| Hungary | 205.452.36008 Boehringer Ingelheim Investigational Site | Farkasgyepü | |
| Hungary | 205.452.36020 Boehringer Ingelheim Investigational Site | Györ | |
| Hungary | 205.452.36012 Boehringer Ingelheim Investigational Site | Hajduböszörmeny | |
| Hungary | 205.452.36023 Boehringer Ingelheim Investigational Site | Hodmezovasarhely | |
| Hungary | 205.452.36010 Boehringer Ingelheim Investigational Site | Kaposvar | |
| Hungary | 205.452.36018 Boehringer Ingelheim Investigational Site | Kapuvar | |
| Hungary | 205.452.36002 Boehringer Ingelheim Investigational Site | Kecskemet | |
| Hungary | 205.452.36001 Boehringer Ingelheim Investigational Site | Makó | |
| Hungary | 205.452.36006 Boehringer Ingelheim Investigational Site | Mohacs | |
| Hungary | 205.452.36022 Boehringer Ingelheim Investigational Site | Mosonmagyarovar | |
| Hungary | 205.452.36027 Boehringer Ingelheim Investigational Site | Nagykanizsa | |
| Hungary | 205.452.36014 Boehringer Ingelheim Investigational Site | Nyiregyhaza | |
| Hungary | 205.452.36009 Boehringer Ingelheim Investigational Site | Pecs | |
| Hungary | 205.452.36011 Boehringer Ingelheim Investigational Site | Pecs | |
| Hungary | 205.452.36028 Boehringer Ingelheim Investigational Site | Siófok | |
| Hungary | 205.452.36021 Boehringer Ingelheim Investigational Site | Szarvas | |
| Hungary | 205.452.36017 Boehringer Ingelheim Investigational Site | Szeged | |
| Hungary | 205.452.36024 Boehringer Ingelheim Investigational Site | Tatabanya | |
| Hungary | 205.452.36019 Boehringer Ingelheim Investigational Site | Törökbálint | |
| Hungary | 205.452.36025 Boehringer Ingelheim Investigational Site | Törökbálint | |
| India | 205.452.91017 Boehringer Ingelheim Investigational Site | Ahmedabad | |
| India | 205.452.91018 Boehringer Ingelheim Investigational Site | Chennai | |
| India | 205.452.91001 Boehringer Ingelheim Investigational Site | Coimbatore | |
| India | 205.452.91002 Boehringer Ingelheim Investigational Site | Coimbatore | |
| India | 205.452.91014 Boehringer Ingelheim Investigational Site | Dadar(East) | |
| India | 205.452.91005 Boehringer Ingelheim Investigational Site | Hyderabad | |
| India | 205.452.91009 Boehringer Ingelheim Investigational Site | Hyderabad | |
| India | 205.452.91004 Boehringer Ingelheim Investigational Site | Jaipur | |
| India | 205.452.91007 Boehringer Ingelheim Investigational Site | Jaipur | |
| India | 205.452.91015 Boehringer Ingelheim Investigational Site | Jaipur | |
| India | 205.452.91016 Boehringer Ingelheim Investigational Site | Jaipur | |
| India | 205.452.91008 Boehringer Ingelheim Investigational Site | Karnataka | |
| India | 205.452.91006 Boehringer Ingelheim Investigational Site | Maharashtra | |
| India | 205.452.91003 Boehringer Ingelheim Investigational Site | Maharastra | |
| India | 205.452.91011 Boehringer Ingelheim Investigational Site | Punjab | |
| Ireland | 205.452.35307 Boehringer Ingelheim Investigational Site | Co. Cork | |
| Ireland | 205.452.35306 Boehringer Ingelheim Investigational Site | Co. Tipperary | |
| Ireland | 205.452.35305 Boehringer Ingelheim Investigational Site | Co. Wexford | |
| Ireland | 205.452.35302 Boehringer Ingelheim Investigational Site | Dublin | |
| Ireland | 205.452.35301 Boehringer Ingelheim Investigational Site | Dublin 24 | |
| Ireland | 205.452.35303 Boehringer Ingelheim Investigational Site | Limerick | |
| Ireland | 205.452.35308 Boehringer Ingelheim Investigational Site | Limerick | |
| Ireland | 205.452.35304 Boehringer Ingelheim Investigational Site | Offaly | |
| Israel | 205.452.97207 Boehringer Ingelheim Investigational Site | Ashkelon | |
| Israel | 205.452.97204 Boehringer Ingelheim Investigational Site | Beer Sheva | |
| Israel | 205.452.97208 Boehringer Ingelheim Investigational Site | Haifa | |
| Israel | 205.452.97202 Boehringer Ingelheim Investigational Site | Jerusalem | |
| Israel | 205.452.97206 Boehringer Ingelheim Investigational Site | Kfar Saba | |
| Israel | 205.452.97203 Boehringer Ingelheim Investigational Site | Petach Tikva | |
| Israel | 205.452.97201 Boehringer Ingelheim Investigational Site | Rehovot | |
| Israel | 205.452.97205 Boehringer Ingelheim Investigational Site | Tel-Aviv | |
| Italy | 205.452.39003 Boehringer Ingelheim Investigational Site | Arenzano (ge) | |
| Italy | 205.452.39019 Boehringer Ingelheim Investigational Site | Ascoli Piceno | |
| Italy | 205.452.39016 Boehringer Ingelheim Investigational Site | Avellino | |
| Italy | 205.452.39007 Boehringer Ingelheim Investigational Site | Benevento | |
| Italy | 205.452.39024 Boehringer Ingelheim Investigational Site | Brescia | |
| Italy | 205.452.39029 Boehringer Ingelheim Investigational Site | Busto Arsizio (va) | |
| Italy | 205.452.39011 Boehringer Ingelheim Investigational Site | Cagliari | |
| Italy | 205.452.39013 Boehringer Ingelheim Investigational Site | Cagliari | |
| Italy | 205.452.39020 Boehringer Ingelheim Investigational Site | Cagliari | |
| Italy | 205.452.39015 Boehringer Ingelheim Investigational Site | Catanzaro | |
| Italy | 205.452.39006 Boehringer Ingelheim Investigational Site | Chieti Scalo | |
| Italy | 205.452.39001 Boehringer Ingelheim Investigational Site | Firenze | |
| Italy | 205.452.39021 Boehringer Ingelheim Investigational Site | Monza | |
| Italy | 205.452.39014 Boehringer Ingelheim Investigational Site | Napoli | |
| Italy | 205.452.39012 Boehringer Ingelheim Investigational Site | Orbassano (to) | |
| Italy | 205.452.39026 Boehringer Ingelheim Investigational Site | Orbassano (to) | |
| Italy | 205.452.39010 Boehringer Ingelheim Investigational Site | Palermo | |
| Italy | 205.452.39005 Boehringer Ingelheim Investigational Site | Parma | |
| Italy | 205.452.39009 Boehringer Ingelheim Investigational Site | Perugia | |
| Italy | 205.452.39002 Boehringer Ingelheim Investigational Site | Prato | |
| Italy | 205.452.39030 Boehringer Ingelheim Investigational Site | Reggio Emilia | |
| Italy | 205.452.39004 Boehringer Ingelheim Investigational Site | Roma | |
| Italy | 205.452.39017 Boehringer Ingelheim Investigational Site | Roma | |
| Italy | 205.452.39027 Boehringer Ingelheim Investigational Site | Roma | |
| Italy | 205.452.39023 Boehringer Ingelheim Investigational Site | Treviso | |
| Korea, Republic of | 205.452.82008 Boehringer Ingelheim Investigational Site | Bucheon | |
| Korea, Republic of | 205.452.82002 Boehringer Ingelheim Investigational Site | Busan | |
| Korea, Republic of | 205.452.82012 Boehringer Ingelheim Investigational Site | Busan | |
| Korea, Republic of | 205.452.82010 Boehringer Ingelheim Investigational Site | Daegu | |
| Korea, Republic of | 205.452.82016 Boehringer Ingelheim Investigational Site | Daejoen | |
| Korea, Republic of | 205.452.82009 Boehringer Ingelheim Investigational Site | Gangwon-Do | |
| Korea, Republic of | 205.452.82017 Boehringer Ingelheim Investigational Site | Goyang | |
| Korea, Republic of | 205.452.82004 Boehringer Ingelheim Investigational Site | Gwangju | |
| Korea, Republic of | 205.452.82005 Boehringer Ingelheim Investigational Site | Incheon | |
| Korea, Republic of | 205.452.82020 Boehringer Ingelheim Investigational Site | Jeonju | |
| Korea, Republic of | 205.452.82001 Boehringer Ingelheim Investigational Site | Seoul | |
| Korea, Republic of | 205.452.82003 Boehringer Ingelheim Investigational Site | Seoul | |
| Korea, Republic of | 205.452.82006 Boehringer Ingelheim Investigational Site | Seoul | |
| Korea, Republic of | 205.452.82007 Boehringer Ingelheim Investigational Site | Seoul | |
| Korea, Republic of | 205.452.82011 Boehringer Ingelheim Investigational Site | Seoul | |
| Korea, Republic of | 205.452.82013 Boehringer Ingelheim Investigational Site | Seoul | |
| Korea, Republic of | 205.452.82014 Boehringer Ingelheim Investigational Site | Seoul | |
| Korea, Republic of | 205.452.82015 Boehringer Ingelheim Investigational Site | Seoul | |
| Korea, Republic of | 205.452.82018 Boehringer Ingelheim Investigational Site | Seoul | |
| Korea, Republic of | 205.452.82019 Boehringer Ingelheim Investigational Site | Uijeongbu | |
| Latvia | 205.452.37106 Boehringer Ingelheim Investigational Site | Daugavpils | |
| Latvia | 205.452.37107 Boehringer Ingelheim Investigational Site | Daugavpils | |
| Latvia | 205.452.37108 Boehringer Ingelheim Investigational Site | Daugavpils | |
| Latvia | 205.452.37102 Boehringer Ingelheim Investigational Site | Kraslava | |
| Latvia | 205.452.37104 Boehringer Ingelheim Investigational Site | Riga | |
| Latvia | 205.452.37105 Boehringer Ingelheim Investigational Site | Riga | |
| Latvia | 205.452.37109 Boehringer Ingelheim Investigational Site | Riga | |
| Latvia | 205.452.37110 Boehringer Ingelheim Investigational Site | Riga | |
| Latvia | 205.452.37101 Boehringer Ingelheim Investigational Site | Talsi | |
| Latvia | 205.452.37103 Boehringer Ingelheim Investigational Site | Valmiera | |
| Lithuania | 205.452.37003 Boehringer Ingelheim Investigational Site | Alytus | |
| Lithuania | 205.452.37001 Boehringer Ingelheim Investigational Site | Kaunas | |
| Lithuania | 205.452.37002 Boehringer Ingelheim Investigational Site | Kaunas | |
| Lithuania | 205.452.37005 Boehringer Ingelheim Investigational Site | Klaipeda | |
| Lithuania | 205.452.37007 Boehringer Ingelheim Investigational Site | Siauliai | |
| Lithuania | 205.452.37011 Boehringer Ingelheim Investigational Site | Utena | |
| Lithuania | 205.452.37004 Boehringer Ingelheim Investigational Site | Vilnius | |
| Lithuania | 205.452.37008 Boehringer Ingelheim Investigational Site | Vilnius | |
| Lithuania | 205.452.37010 Boehringer Ingelheim Investigational Site | Vilnius | |
| Malaysia | 205.452.60006 Boehringer Ingelheim Investigational Site | Johor Bahru | |
| Malaysia | 205.452.60001 Boehringer Ingelheim Investigational Site | Kuala Lumpur | |
| Malaysia | 205.452.60002 Boehringer Ingelheim Investigational Site | Kuala Lumpur | |
| Malaysia | 205.452.60004 Boehringer Ingelheim Investigational Site | Kuala Lumpur | |
| Malaysia | 205.452.60008 Boehringer Ingelheim Investigational Site | Pahang | |
| Malaysia | 205.452.60005 Boehringer Ingelheim Investigational Site | Sarawak | |
| Malaysia | 205.452.60009 Boehringer Ingelheim Investigational Site | Selangor | |
| Malaysia | 205.452.60007 Boehringer Ingelheim Investigational Site | Terengganu | |
| Mexico | 205.452.52004 Boehringer Ingelheim Investigational Site | Aguascalientes | |
| Mexico | 205.452.52007 Boehringer Ingelheim Investigational Site | Distrito Federal | |
| Mexico | 205.452.52005 Boehringer Ingelheim Investigational Site | Guadalajara | |
| Mexico | 205.452.52001 Boehringer Ingelheim Investigational Site | México | |
| Mexico | 205.452.52002 Boehringer Ingelheim Investigational Site | Monte Rey | |
| Mexico | 205.452.52003 Boehringer Ingelheim Investigational Site | Zona Río | |
| Netherlands | 205.452.31001 Boehringer Ingelheim Investigational Site | Almere | |
| Netherlands | 205.452.31008 Boehringer Ingelheim Investigational Site | Andijk | |
| Netherlands | 205.452.31002 Boehringer Ingelheim Investigational Site | Beek | |
| Netherlands | 205.452.31012 Boehringer Ingelheim Investigational Site | Beek En Donk | |
| Netherlands | 205.452.31003 Boehringer Ingelheim Investigational Site | Ermelo | |
| Netherlands | 205.452.31010 Boehringer Ingelheim Investigational Site | Hoogwoud | |
| Netherlands | 205.452.31011 Boehringer Ingelheim Investigational Site | Nijverdal | |
| Netherlands | 205.452.31007 Boehringer Ingelheim Investigational Site | Oude Pekela | |
| Netherlands | 205.452.31005 Boehringer Ingelheim Investigational Site | Roelofarendsveen | |
| New Zealand | 205.452.64004 Boehringer Ingelheim Investigational Site | Christchurch | |
| New Zealand | 205.452.64003 Boehringer Ingelheim Investigational Site | Dunedin | |
| New Zealand | 205.452.64002 Boehringer Ingelheim Investigational Site | Newtown Wellington NZ | |
| New Zealand | 205.452.64001 Boehringer Ingelheim Investigational Site | Tauranga | |
| Norway | 205.452.47008 Boehringer Ingelheim Investigational Site | Drammen | |
| Norway | 205.452.47009 Boehringer Ingelheim Investigational Site | Fredrikstad | |
| Norway | 205.452.47001 Boehringer Ingelheim Investigational Site | Hønefoss | |
| Norway | 205.452.47010 Boehringer Ingelheim Investigational Site | Kløfta | |
| Norway | 205.452.47007 Boehringer Ingelheim Investigational Site | Kolbjørnsvik | |
| Norway | 205.452.47005 Boehringer Ingelheim Investigational Site | Løvenstad | |
| Norway | 205.452.47002 Boehringer Ingelheim Investigational Site | Oslo | |
| Norway | 205.452.47003 Boehringer Ingelheim Investigational Site | Oslo | |
| Norway | 205.452.47011 Boehringer Ingelheim Investigational Site | Oslo | |
| Norway | 205.452.47012 Boehringer Ingelheim Investigational Site | Sandvika | |
| Norway | 205.452.47004 Boehringer Ingelheim Investigational Site | Svelvik | |
| Norway | 205.452.47006 Boehringer Ingelheim Investigational Site | Trollåsen | |
| Panama | 205.452.50703 Boehringer Ingelheim Investigational Site | Carrasquilla | |
| Panama | 205.452.50701 Boehringer Ingelheim Investigational Site | Marbella | |
| Panama | 205.452.50702 Boehringer Ingelheim Investigational Site | Marbella | |
| Peru | 205.452.51002 Boehringer Ingelheim Investigational Site | Bellavista | |
| Peru | 205.452.51003 Boehringer Ingelheim Investigational Site | Cusco | |
| Peru | 205.452.51004 Boehringer Ingelheim Investigational Site | Jesús Maria | |
| Peru | 205.452.51007 Boehringer Ingelheim Investigational Site | Jesús María | |
| Peru | 205.452.51005 Boehringer Ingelheim Investigational Site | Lima | |
| Peru | 205.452.51001 Boehringer Ingelheim Investigational Site | San Isidro | |
| Peru | 205.452.51006 Boehringer Ingelheim Investigational Site | San Martin de Porres | |
| Philippines | 205.452.63004 Boehringer Ingelheim Investigational Site | Cavite City | |
| Philippines | 205.452.63002 Boehringer Ingelheim Investigational Site | Davao City | |
| Philippines | 205.452.63003 Boehringer Ingelheim Investigational Site | Iloilo City | |
| Philippines | 205.452.63006 Boehringer Ingelheim Investigational Site | Iloilo City | |
| Philippines | 205.452.63001 Boehringer Ingelheim Investigational Site | Manila | |
| Philippines | 205.452.63008 Boehringer Ingelheim Investigational Site | Manila | |
| Philippines | 205.452.63005 Boehringer Ingelheim Investigational Site | Quezon City | |
| Philippines | 205.452.63007 Boehringer Ingelheim Investigational Site | Quezon City | |
| Poland | 205.452.48031 Boehringer Ingelheim Investigational Site | Babice | |
| Poland | 205.452.48003 Boehringer Ingelheim Investigational Site | Bialystok | |
| Poland | 205.452.48011 Boehringer Ingelheim Investigational Site | Bialystok | |
| Poland | 205.452.48014 Boehringer Ingelheim Investigational Site | Bydgoszcz | |
| Poland | 205.452.48008 Boehringer Ingelheim Investigational Site | Checiny | |
| Poland | 205.452.48016 Boehringer Ingelheim Investigational Site | Gdansk | |
| Poland | 205.452.48019 Boehringer Ingelheim Investigational Site | Gdynia | |
| Poland | 205.452.48037 Boehringer Ingelheim Investigational Site | Gorzow Wlkp | |
| Poland | 205.452.48015 Boehringer Ingelheim Investigational Site | Ilawa | |
| Poland | 205.452.48033 Boehringer Ingelheim Investigational Site | Katowice | |
| Poland | 205.452.48039 Boehringer Ingelheim Investigational Site | Katowice | |
| Poland | 205.452.48044 Boehringer Ingelheim Investigational Site | Katowice | |
| Poland | 205.452.48009 Boehringer Ingelheim Investigational Site | Krakow | |
| Poland | 205.452.48021 Boehringer Ingelheim Investigational Site | Krakow | |
| Poland | 205.452.48029 Boehringer Ingelheim Investigational Site | Krakow | |
| Poland | 205.452.48030 Boehringer Ingelheim Investigational Site | Krakow | |
| Poland | 205.452.48048 Boehringer Ingelheim Investigational Site | Krakow | |
| Poland | 205.452.48043 Boehringer Ingelheim Investigational Site | Libiaz | |
| Poland | 205.452.48002 Boehringer Ingelheim Investigational Site | Lodz | |
| Poland | 205.452.48051 Boehringer Ingelheim Investigational Site | Lodz | |
| Poland | 205.452.48056 Boehringer Ingelheim Investigational Site | Lodz | |
| Poland | 205.452.48059 Boehringer Ingelheim Investigational Site | Lodz | |
| Poland | 205.452.48018 Boehringer Ingelheim Investigational Site | Olsztyn | |
| Poland | 205.452.48025 Boehringer Ingelheim Investigational Site | Ostrow Wielkopolska | |
| Poland | 205.452.48012 Boehringer Ingelheim Investigational Site | Piaseczno | |
| Poland | 205.452.48040 Boehringer Ingelheim Investigational Site | Piaseczno | |
| Poland | 205.452.48026 Boehringer Ingelheim Investigational Site | Poznan | |
| Poland | 205.452.48027 Boehringer Ingelheim Investigational Site | Poznan | |
| Poland | 205.452.48058 Boehringer Ingelheim Investigational Site | Poznan | |
| Poland | 205.452.48060 Boehringer Ingelheim Investigational Site | Rokietnica | |
| Poland | 205.452.48001 Boehringer Ingelheim Investigational Site | Skierniewice | |
| Poland | 205.452.48032 Boehringer Ingelheim Investigational Site | Slawkow | |
| Poland | 205.452.48036 Boehringer Ingelheim Investigational Site | Szczecin | |
| Poland | 205.452.48045 Boehringer Ingelheim Investigational Site | Tarnow | |
| Poland | 205.452.48057 Boehringer Ingelheim Investigational Site | Tczew | |
| Poland | 205.452.48004 Boehringer Ingelheim Investigational Site | Torun | |
| Poland | 205.452.48007 Boehringer Ingelheim Investigational Site | Tranow | |
| Poland | 205.452.48053 Boehringer Ingelheim Investigational Site | Turek | |
| Poland | 205.452.48034 Boehringer Ingelheim Investigational Site | Warsaw | |
| Poland | 205.452.48042 Boehringer Ingelheim Investigational Site | Warszawa | |
| Poland | 205.452.48049 Boehringer Ingelheim Investigational Site | Warszawa | |
| Poland | 205.452.48017 Boehringer Ingelheim Investigational Site | Wolomin | |
| Poland | 205.452.48006 Boehringer Ingelheim Investigational Site | Wroclaw | |
| Poland | 205.452.48028 Boehringer Ingelheim Investigational Site | Wroclaw | |
| Poland | 205.452.48035 Boehringer Ingelheim Investigational Site | Wroclaw | |
| Poland | 205.452.48038 Boehringer Ingelheim Investigational Site | Wroclaw | |
| Poland | 205.452.48022 Boehringer Ingelheim Investigational Site | Zakopane | |
| Portugal | 205.452.35103 Boehringer Ingelheim Investigational Site | Amadora | |
| Portugal | 205.452.35102 Boehringer Ingelheim Investigational Site | Coimbra | |
| Portugal | 205.452.35107 Boehringer Ingelheim Investigational Site | Lisboa | |
| Portugal | 205.452.35108 Boehringer Ingelheim Investigational Site | Lisboa | |
| Portugal | 205.452.35101 Boehringer Ingelheim Investigational Site | Matosinhos | |
| Portugal | 205.452.35105 Boehringer Ingelheim Investigational Site | Penafiel | |
| Portugal | 205.452.35106 Boehringer Ingelheim Investigational Site | Vila Nova de Gaia | |
| Portugal | 205.452.35104 Boehringer Ingelheim Investigational Site | Viseu | |
| Puerto Rico | 205.452.01177 Boehringer Ingelheim Investigational Site | Ponce | |
| Puerto Rico | 205.452.01162 Boehringer Ingelheim Investigational Site | San Juan | |
| Romania | 205.452.40008 Boehringer Ingelheim Investigational Site | Brasov | |
| Romania | 205.452.40012 Boehringer Ingelheim Investigational Site | Brasov | |
| Romania | 205.452.40001 Boehringer Ingelheim Investigational Site | Bucharest | |
| Romania | 205.452.40003 Boehringer Ingelheim Investigational Site | Bucharest | |
| Romania | 205.452.40004 Boehringer Ingelheim Investigational Site | Bucharest | |
| Romania | 205.452.40007 Boehringer Ingelheim Investigational Site | Bucharest | |
| Romania | 205.452.40009 Boehringer Ingelheim Investigational Site | Bucharest | |
| Romania | 205.452.40013 Boehringer Ingelheim Investigational Site | Bucharest | |
| Romania | 205.452.40002 Boehringer Ingelheim Investigational Site | Bucuresti | |
| Romania | 205.452.40011 Boehringer Ingelheim Investigational Site | Constanta | |
| Romania | 205.452.40006 Boehringer Ingelheim Investigational Site | Craiova | |
| Russian Federation | 205.452.07030 Boehringer Ingelheim Investigational Site | Arkhangelsk | |
| Russian Federation | 205.452.07049 Boehringer Ingelheim Investigational Site | Barnaul | |
| Russian Federation | 205.452.07054 Boehringer Ingelheim Investigational Site | Barnaul | |
| Russian Federation | 205.452.07053 Boehringer Ingelheim Investigational Site | Chelyabinsk | |
| Russian Federation | 205.452.07031 Boehringer Ingelheim Investigational Site | Ekaterinburg | |
| Russian Federation | 205.452.07038 Boehringer Ingelheim Investigational Site | Gatchina (Leningradskaya oblast) | |
| Russian Federation | 205.452.07036 Boehringer Ingelheim Investigational Site | Irkutsk | |
| Russian Federation | 205.452.07001 Boehringer Ingelheim Investigational Site | Ivanovo | |
| Russian Federation | 205.452.07023 Boehringer Ingelheim Investigational Site | Kaliningrad | |
| Russian Federation | 205.452.07003 Boehringer Ingelheim Investigational Site | Kazan | |
| Russian Federation | 205.452.07005 Boehringer Ingelheim Investigational Site | Kazan | |
| Russian Federation | 205.452.07007 Boehringer Ingelheim Investigational Site | Kazan | |
| Russian Federation | 205.452.07048 Boehringer Ingelheim Investigational Site | Kemerovo | |
| Russian Federation | 205.452.07060 Boehringer Ingelheim Investigational Site | Kemerovo | |
| Russian Federation | 205.452.07059 Boehringer Ingelheim Investigational Site | Kirov | |
| Russian Federation | 205.452.07009 Boehringer Ingelheim Investigational Site | Krasnodar | |
| Russian Federation | 205.452.07010 Boehringer Ingelheim Investigational Site | Krasnodar | |
| Russian Federation | 205.452.07013 Boehringer Ingelheim Investigational Site | Moscow | |
| Russian Federation | 205.452.07020 Boehringer Ingelheim Investigational Site | Moscow | |
| Russian Federation | 205.452.07021 Boehringer Ingelheim Investigational Site | Moscow | |
| Russian Federation | 205.452.07026 Boehringer Ingelheim Investigational Site | Moscow | |
| Russian Federation | 205.452.07027 Boehringer Ingelheim Investigational Site | Moscow | |
| Russian Federation | 205.452.07028 Boehringer Ingelheim Investigational Site | Moscow | |
| Russian Federation | 205.452.07029 Boehringer Ingelheim Investigational Site | Moscow | |
| Russian Federation | 205.452.07043 Boehringer Ingelheim Investigational Site | Moscow | |
| Russian Federation | 205.452.07045 Boehringer Ingelheim Investigational Site | Moscow | |
| Russian Federation | 205.452.07004 Boehringer Ingelheim Investigational Site | Murmansk | |
| Russian Federation | 205.452.07055 Boehringer Ingelheim Investigational Site | Nizhniy Novgorod | |
| Russian Federation | 205.452.07051 Boehringer Ingelheim Investigational Site | Nizhny Novgorod | |
| Russian Federation | 205.452.07037 Boehringer Ingelheim Investigational Site | Novosibirsk | |
| Russian Federation | 205.452.07040 Boehringer Ingelheim Investigational Site | Novosibirsk | |
| Russian Federation | 205.452.07042 Boehringer Ingelheim Investigational Site | Novosibirsk | |
| Russian Federation | 205.452.07041 Boehringer Ingelheim Investigational Site | Penza | |
| Russian Federation | 205.452.07050 Boehringer Ingelheim Investigational Site | Pskov | |
| Russian Federation | 205.452.07015 Boehringer Ingelheim Investigational Site | Rostov-na-Donu | |
| Russian Federation | 205.452.07016 Boehringer Ingelheim Investigational Site | Rostov-on-Don | |
| Russian Federation | 205.452.07039 Boehringer Ingelheim Investigational Site | Ryazan | |
| Russian Federation | 205.452.07034 Boehringer Ingelheim Investigational Site | Samara | |
| Russian Federation | 205.452.07047 Boehringer Ingelheim Investigational Site | Saratov | |
| Russian Federation | 205.452.07002 Boehringer Ingelheim Investigational Site | St. Petersburg | |
| Russian Federation | 205.452.07006 Boehringer Ingelheim Investigational Site | St. Petersburg | |
| Russian Federation | 205.452.07011 Boehringer Ingelheim Investigational Site | St. Petersburg | |
| Russian Federation | 205.452.07014 Boehringer Ingelheim Investigational Site | St. Petersburg | |
| Russian Federation | 205.452.07017 Boehringer Ingelheim Investigational Site | St. Petersburg | |
| Russian Federation | 205.452.07018 Boehringer Ingelheim Investigational Site | St. Petersburg | |
| Russian Federation | 205.452.07022 Boehringer Ingelheim Investigational Site | St. Petersburg | |
| Russian Federation | 205.452.07024 Boehringer Ingelheim Investigational Site | St. Petersburg | |
| Russian Federation | 205.452.07025 Boehringer Ingelheim Investigational Site | St. Petersburg | |
| Russian Federation | 205.452.07033 Boehringer Ingelheim Investigational Site | St. Petersburg | |
| Russian Federation | 205.452.07046 Boehringer Ingelheim Investigational Site | St. Petersburg | |
| Russian Federation | 205.452.07052 Boehringer Ingelheim Investigational Site | St. Petersburg | |
| Russian Federation | 205.452.07032 Boehringer Ingelheim Investigational Site | Tomsk | |
| Russian Federation | 205.452.07035 Boehringer Ingelheim Investigational Site | Tomsk | |
| Russian Federation | 205.452.07057 Boehringer Ingelheim Investigational Site | Tomsk | |
| Russian Federation | 205.452.07019 Boehringer Ingelheim Investigational Site | Velikiy Novgorod | |
| Russian Federation | 205.452.07044 Boehringer Ingelheim Investigational Site | Yaroslavl | |
| Serbia | 205.452.38103 Boehringer Ingelheim Investigational Site | Belgrade | |
| Serbia | 205.452.38104 Boehringer Ingelheim Investigational Site | Belgrade | |
| Serbia | 205.452.38106 Boehringer Ingelheim Investigational Site | Belgrade | |
| Serbia | 205.452.38107 Boehringer Ingelheim Investigational Site | Belgrade | |
| Serbia | 205.452.38102 Boehringer Ingelheim Investigational Site | Kragujevac | |
| Serbia | 205.452.38105 Boehringer Ingelheim Investigational Site | Nis | |
| Serbia | 205.452.38101 Boehringer Ingelheim Investigational Site | Sremska Kamenica | |
| Slovakia | 205.452.42103 Boehringer Ingelheim Investigational Site | Bardejov | |
| Slovakia | 205.452.42107 Boehringer Ingelheim Investigational Site | Bratislava | |
| Slovakia | 205.452.42102 Boehringer Ingelheim Investigational Site | Humenne | |
| Slovakia | 205.452.42105 Boehringer Ingelheim Investigational Site | Kosice | |
| Slovakia | 205.452.42111 Boehringer Ingelheim Investigational Site | Kosice | |
| Slovakia | 205.452.42113 Boehringer Ingelheim Investigational Site | Kosice | |
| Slovakia | 205.452.42108 Boehringer Ingelheim Investigational Site | Levice | |
| Slovakia | 205.452.42109 Boehringer Ingelheim Investigational Site | Martin | |
| Slovakia | 205.452.42112 Boehringer Ingelheim Investigational Site | Poprad | |
| Slovakia | 205.452.42101 Boehringer Ingelheim Investigational Site | Presov | |
| Slovakia | 205.452.42104 Boehringer Ingelheim Investigational Site | Rimavska Sobota | |
| Slovakia | 205.452.42106 Boehringer Ingelheim Investigational Site | Spisska Nova Ves | |
| Slovakia | 205.452.42110 Boehringer Ingelheim Investigational Site | Sturovo | |
| South Africa | 205.452.27013 Boehringer Ingelheim Investigational Site | Amanzimtoti | |
| South Africa | 205.452.27002 Boehringer Ingelheim Investigational Site | Bellville | |
| South Africa | 205.452.27010 Boehringer Ingelheim Investigational Site | Bloemfontein | |
| South Africa | 205.452.27001 Boehringer Ingelheim Investigational Site | Cape Town | |
| South Africa | 205.452.27004 Boehringer Ingelheim Investigational Site | Cape Town | |
| South Africa | 205.452.27008 Boehringer Ingelheim Investigational Site | Cape Town | |
| South Africa | 205.452.27011 Boehringer Ingelheim Investigational Site | Cape Town | |
| South Africa | 205.452.27012 Boehringer Ingelheim Investigational Site | Cape Town | |
| South Africa | 205.452.27006 Boehringer Ingelheim Investigational Site | Centurion | |
| South Africa | 205.452.27003 Boehringer Ingelheim Investigational Site | Durban | |
| South Africa | 205.452.27014 Boehringer Ingelheim Investigational Site | Johannesburg | |
| South Africa | 205.452.27005 Boehringer Ingelheim Investigational Site | Pretoria | |
| South Africa | 205.452.27009 Boehringer Ingelheim Investigational Site | Pretoria | |
| South Africa | 205.452.27007 Boehringer Ingelheim Investigational Site | Somerset West | |
| Spain | 205.452.34018 Boehringer Ingelheim Investigational Site | Badajoz | |
| Spain | 205.452.34021 Boehringer Ingelheim Investigational Site | Badalona (Barcelona) | |
| Spain | 205.452.34010 Boehringer Ingelheim Investigational Site | Barcelona | |
| Spain | 205.452.34025 Boehringer Ingelheim Investigational Site | Barcelona | |
| Spain | 205.452.34015 Boehringer Ingelheim Investigational Site | Cáceres | |
| Spain | 205.452.34027 Boehringer Ingelheim Investigational Site | Centelles | |
| Spain | 205.452.34016 Boehringer Ingelheim Investigational Site | Elda | |
| Spain | 205.452.34008 Boehringer Ingelheim Investigational Site | Hospitalet de Llobregat | |
| Spain | 205.452.34026 Boehringer Ingelheim Investigational Site | Lugo | |
| Spain | 205.452.34011 Boehringer Ingelheim Investigational Site | Madrid | |
| Spain | 205.452.34019 Boehringer Ingelheim Investigational Site | Madrid | |
| Spain | 205.452.34020 Boehringer Ingelheim Investigational Site | Málaga | |
| Spain | 205.452.34002 Boehringer Ingelheim Investigational Site | Mérida | |
| Spain | 205.452.34017 Boehringer Ingelheim Investigational Site | Plasencia | |
| Spain | 205.452.34001 Boehringer Ingelheim Investigational Site | Pozuelo de Alarcón | |
| Spain | 205.452.34024 Boehringer Ingelheim Investigational Site | San Juan de Alicante | |
| Spain | 205.452.34003 Boehringer Ingelheim Investigational Site | Santander | |
| Spain | 205.452.34005 Boehringer Ingelheim Investigational Site | Terrassa (Barcelona) | |
| Spain | 205.452.34007 Boehringer Ingelheim Investigational Site | Torrevieja | |
| Spain | 205.452.34012 Boehringer Ingelheim Investigational Site | Valencia | |
| Spain | 205.452.34013 Boehringer Ingelheim Investigational Site | Valladolid | |
| Spain | 205.452.34009 Boehringer Ingelheim Investigational Site | Vic (Barcelona) | |
| Spain | 205.452.34023 Boehringer Ingelheim Investigational Site | Vilanova i la Geltrú | |
| Spain | 205.452.34004 Boehringer Ingelheim Investigational Site | Zaragoza | |
| Sweden | 205.452.46005 Boehringer Ingelheim Investigational Site | Brämhult | |
| Sweden | 205.452.46014 Boehringer Ingelheim Investigational Site | Eksjö | |
| Sweden | 205.452.46013 Boehringer Ingelheim Investigational Site | Göteborg | |
| Sweden | 205.452.46012 Boehringer Ingelheim Investigational Site | Gullspång | |
| Sweden | 205.452.46001 Boehringer Ingelheim Investigational Site | Höllviken | |
| Sweden | 205.452.46008 Boehringer Ingelheim Investigational Site | Järfälla | |
| Sweden | 205.452.46009 Boehringer Ingelheim Investigational Site | Kil | |
| Sweden | 205.452.46007 Boehringer Ingelheim Investigational Site | Lidingö | |
| Sweden | 205.452.46003 Boehringer Ingelheim Investigational Site | Luleå | |
| Sweden | 205.452.46006 Boehringer Ingelheim Investigational Site | Örebro | |
| Sweden | 205.452.46010 Boehringer Ingelheim Investigational Site | Sigtuna | |
| Sweden | 205.452.46002 Boehringer Ingelheim Investigational Site | Solna | |
| Sweden | 205.452.46011 Boehringer Ingelheim Investigational Site | Uddevalla | |
| Switzerland | 205.452.41003 Boehringer Ingelheim Investigational Site | Ascona | |
| Switzerland | 205.452.41004 Boehringer Ingelheim Investigational Site | Basel | |
| Switzerland | 205.452.41016 Boehringer Ingelheim Investigational Site | Bern | |
| Switzerland | 205.452.41012 Boehringer Ingelheim Investigational Site | Glarus | |
| Switzerland | 205.452.41001 Boehringer Ingelheim Investigational Site | Gossau | |
| Switzerland | 205.452.41015 Boehringer Ingelheim Investigational Site | Liestal | |
| Switzerland | 205.452.41010 Boehringer Ingelheim Investigational Site | Locarno | |
| Switzerland | 205.452.41011 Boehringer Ingelheim Investigational Site | Lugano | |
| Switzerland | 205.452.41007 Boehringer Ingelheim Investigational Site | Spiez | |
| Switzerland | 205.452.41002 Boehringer Ingelheim Investigational Site | St. Gallen | |
| Switzerland | 205.452.41009 Boehringer Ingelheim Investigational Site | St. Gallen | |
| Switzerland | 205.452.41013 Boehringer Ingelheim Investigational Site | Zürich | |
| Switzerland | 205.452.41014 Boehringer Ingelheim Investigational Site | Zürich | |
| Taiwan | 205.452.88607 Boehringer Ingelheim Investigational Site | Changhua | |
| Taiwan | 205.452.88614 Boehringer Ingelheim Investigational Site | Chia-Yi | |
| Taiwan | 205.452.88611 Boehringer Ingelheim Investigational Site | Kaohsiung | |
| Taiwan | 205.452.88608 Boehringer Ingelheim Investigational Site | Kaohsiung City | |
| Taiwan | 205.452.88609 Boehringer Ingelheim Investigational Site | Kaohsiung City | |
| Taiwan | 205.452.88604 Boehringer Ingelheim Investigational Site | New Taipei | |
| Taiwan | 205.452.88605 Boehringer Ingelheim Investigational Site | Taichung | |
| Taiwan | 205.452.88606 Boehringer Ingelheim Investigational Site | Taichung | |
| Taiwan | 205.452.88612 Boehringer Ingelheim Investigational Site | Taichung | |
| Taiwan | 205.452.88610 Boehringer Ingelheim Investigational Site | Tainan | |
| Taiwan | 205.452.88602 Boehringer Ingelheim Investigational Site | Taipei | |
| Taiwan | 205.452.88603 Boehringer Ingelheim Investigational Site | Taipei | |
| Taiwan | 205.452.88613 Boehringer Ingelheim Investigational Site | Taipei | |
| Taiwan | 205.452.88601 Boehringer Ingelheim Investigational Site | Taoyuan County | |
| Thailand | 205.452.66004 Boehringer Ingelheim Investigational Site | Chiang Mai | |
| Thailand | 205.452.66003 Boehringer Ingelheim Investigational Site | Hatyai, Songkhla | |
| Thailand | 205.452.66002 Boehringer Ingelheim Investigational Site | Khon Kaen | |
| Thailand | 205.452.66005 Boehringer Ingelheim Investigational Site | Muang, Phitsanulok | |
| Thailand | 205.452.66001 Boehringer Ingelheim Investigational Site | Nonthaburi | |
| Tunisia | 205.452.21603 Boehringer Ingelheim Investigational Site | Ariana | |
| Tunisia | 205.452.21605 Boehringer Ingelheim Investigational Site | Ariana | |
| Tunisia | 205.452.21606 Boehringer Ingelheim Investigational Site | Ariana | |
| Tunisia | 205.452.21607 Boehringer Ingelheim Investigational Site | Ariana | |
| Tunisia | 205.452.21610 Boehringer Ingelheim Investigational Site | Mahdia | |
| Tunisia | 205.452.21609 Boehringer Ingelheim Investigational Site | Monastir | |
| Tunisia | 205.452.21608 Boehringer Ingelheim Investigational Site | Nabeul | |
| Tunisia | 205.452.21601 Boehringer Ingelheim Investigational Site | Tunis | |
| Tunisia | 205.452.21602 Boehringer Ingelheim Investigational Site | Tunis | |
| Tunisia | 205.452.21604 Boehringer Ingelheim Investigational Site | Tunis | |
| Turkey | 205.452.90001 Boehringer Ingelheim Investigational Site | Adana | |
| Turkey | 205.452.90008 Boehringer Ingelheim Investigational Site | Ankara | |
| Turkey | 205.452.90013 Boehringer Ingelheim Investigational Site | Ankara | |
| Turkey | 205.452.90005 Boehringer Ingelheim Investigational Site | Antalya | |
| Turkey | 205.452.90018 Boehringer Ingelheim Investigational Site | Aydin | |
| Turkey | 205.452.90003 Boehringer Ingelheim Investigational Site | Bolu | |
| Turkey | 205.452.90006 Boehringer Ingelheim Investigational Site | Edirne | |
| Turkey | 205.452.90010 Boehringer Ingelheim Investigational Site | Erzurum | |
| Turkey | 205.452.90019 Boehringer Ingelheim Investigational Site | Hatay | |
| Turkey | 205.452.90017 Boehringer Ingelheim Investigational Site | Istanbul | |
| Turkey | 205.452.90020 Boehringer Ingelheim Investigational Site | Istanbul | |
| Turkey | 205.452.90021 Boehringer Ingelheim Investigational Site | Istanbul | |
| Turkey | 205.452.90015 Boehringer Ingelheim Investigational Site | Izmir | |
| Turkey | 205.452.90016 Boehringer Ingelheim Investigational Site | Izmir | |
| Turkey | 205.452.90022 Boehringer Ingelheim Investigational Site | Izmir | |
| Turkey | 205.452.90007 Boehringer Ingelheim Investigational Site | Malatya | |
| Ukraine | 205.452.38028 Boehringer Ingelheim Investigational Site | Crimea | |
| Ukraine | 205.452.38024 Boehringer Ingelheim Investigational Site | Dnipropetrovks | |
| Ukraine | 205.452.38022 Boehringer Ingelheim Investigational Site | Dnipropetrovsk | |
| Ukraine | 205.452.38034 Boehringer Ingelheim Investigational Site | Dnyepropyetrovsk | |
| Ukraine | 205.452.38002 Boehringer Ingelheim Investigational Site | Donetsk | |
| Ukraine | 205.452.38020 Boehringer Ingelheim Investigational Site | Donetsk | |
| Ukraine | 205.452.38011 Boehringer Ingelheim Investigational Site | Ivano-Frankivsk | |
| Ukraine | 205.452.38005 Boehringer Ingelheim Investigational Site | Kharkiv | |
| Ukraine | 205.452.38001 Boehringer Ingelheim Investigational Site | Kharkov | |
| Ukraine | 205.452.38004 Boehringer Ingelheim Investigational Site | Kharkov | |
| Ukraine | 205.452.38006 Boehringer Ingelheim Investigational Site | Kharkov | |
| Ukraine | 205.452.38008 Boehringer Ingelheim Investigational Site | Kharkov | |
| Ukraine | 205.452.38018 Boehringer Ingelheim Investigational Site | Kharkov | |
| Ukraine | 205.452.38003 Boehringer Ingelheim Investigational Site | Kiev | |
| Ukraine | 205.452.38010 Boehringer Ingelheim Investigational Site | Kiev | |
| Ukraine | 205.452.38012 Boehringer Ingelheim Investigational Site | Kiev | |
| Ukraine | 205.452.38013 Boehringer Ingelheim Investigational Site | Kiev | |
| Ukraine | 205.452.38015 Boehringer Ingelheim Investigational Site | Kiev | |
| Ukraine | 205.452.38032 Boehringer Ingelheim Investigational Site | Kiev | |
| Ukraine | 205.452.38026 Boehringer Ingelheim Investigational Site | Nikolayev | |
| Ukraine | 205.452.38023 Boehringer Ingelheim Investigational Site | Odesa | |
| Ukraine | 205.452.38027 Boehringer Ingelheim Investigational Site | Odessa | |
| Ukraine | 205.452.38031 Boehringer Ingelheim Investigational Site | Odessa | |
| Ukraine | 205.452.38017 Boehringer Ingelheim Investigational Site | Simferopol | |
| Ukraine | 205.452.38019 Boehringer Ingelheim Investigational Site | Vinnytsya | |
| Ukraine | 205.452.38030 Boehringer Ingelheim Investigational Site | Zaporizhzhya | |
| United Kingdom | 205.452.44010 Boehringer Ingelheim Investigational Site | Atherstone | |
| United Kingdom | 205.452.44008 Boehringer Ingelheim Investigational Site | Burbage | |
| United Kingdom | 205.452.44004 Boehringer Ingelheim Investigational Site | Chertsey | |
| United Kingdom | 205.452.44002 Boehringer Ingelheim Investigational Site | Chesterfield | |
| United Kingdom | 205.452.44003 Boehringer Ingelheim Investigational Site | Coventry | |
| United Kingdom | 205.452.44001 Boehringer Ingelheim Investigational Site | Exeter | |
| United Kingdom | 205.452.44007 Boehringer Ingelheim Investigational Site | Fowey | |
| United Kingdom | 205.452.44005 Boehringer Ingelheim Investigational Site | Frome | |
| United Kingdom | 205.452.44011 Boehringer Ingelheim Investigational Site | Leamington Spa | |
| United Kingdom | 205.452.44006 Boehringer Ingelheim Investigational Site | St Just, Penzance | |
| United States | 205.452.01079 Boehringer Ingelheim Investigational Site | Abingdon | Virginia |
| United States | 205.452.01061 Boehringer Ingelheim Investigational Site | Albuquerque | New Mexico |
| United States | 205.452.01167 Boehringer Ingelheim Investigational Site | Albuquerque | New Mexico |
| United States | 205.452.01234 Boehringer Ingelheim Investigational Site | Alexandria | Virginia |
| United States | 205.452.01002 Boehringer Ingelheim Investigational Site | Altoona | Pennsylvania |
| United States | 205.452.01302 Boehringer Ingelheim Investigational Site | Anaheim | California |
| United States | 205.452.01070 Boehringer Ingelheim Investigational Site | Anchorage | Alaska |
| United States | 205.452.01340 Boehringer Ingelheim Investigational Site | Anderson | South Carolina |
| United States | 205.452.01270 Boehringer Ingelheim Investigational Site | Ann Arbor | Michigan |
| United States | 205.452.01096 Boehringer Ingelheim Investigational Site | Arlington | Texas |
| United States | 205.452.01330 Boehringer Ingelheim Investigational Site | Arlington Heights | Illinois |
| United States | 205.452.01271 Boehringer Ingelheim Investigational Site | Asheville | North Carolina |
| United States | 205.452.01266 Boehringer Ingelheim Investigational Site | Ashland | Oregon |
| United States | 205.452.01107 Boehringer Ingelheim Investigational Site | Athens | Alabama |
| United States | 205.452.01130 Boehringer Ingelheim Investigational Site | Atlanta | Georgia |
| United States | 205.452.01364 Boehringer Ingelheim Investigational Site | Auburn | Maine |
| United States | 205.452.01047 Boehringer Ingelheim Investigational Site | Austell | Georgia |
| United States | 205.452.01053 Boehringer Ingelheim Investigational Site | Baltimore | Maryland |
| United States | 205.452.01169 Boehringer Ingelheim Investigational Site | Bangor | Maine |
| United States | 205.452.01159 Boehringer Ingelheim Investigational Site | Bayside | New York |
| United States | 205.452.01354 Boehringer Ingelheim Investigational Site | Beaver | Pennsylvania |
| United States | 205.452.01248 Boehringer Ingelheim Investigational Site | Belleville | Illinois |
| United States | 205.452.01150 Boehringer Ingelheim Investigational Site | Bellevue | Nebraska |
| United States | 205.452.01083 Boehringer Ingelheim Investigational Site | Bend | Oregon |
| United States | 205.452.01349 Boehringer Ingelheim Investigational Site | Benzonia | Michigan |
| United States | 205.452.01022 Boehringer Ingelheim Investigational Site | Biddeford | Maine |
| United States | 205.452.01226 Boehringer Ingelheim Investigational Site | Billings | Montana |
| United States | 205.452.01023 Boehringer Ingelheim Investigational Site | Birmingham | Alabama |
| United States | 205.452.01035 Boehringer Ingelheim Investigational Site | Birmingham | Alabama |
| United States | 205.452.01052 Boehringer Ingelheim Investigational Site | Birmingham | Alabama |
| United States | 205.452.01219 Boehringer Ingelheim Investigational Site | Birmingham | Alabama |
| United States | 205.452.01227 Boehringer Ingelheim Investigational Site | Birmingham | Alabama |
| United States | 205.452.01280 Boehringer Ingelheim Investigational Site | Birmingham | Alabama |
| United States | 205.452.01165 Boehringer Ingelheim Investigational Site | Boise | Idaho |
| United States | 205.452.01063 Boehringer Ingelheim Investigational Site | Bowling Green | Kentucky |
| United States | 205.452.01126 Boehringer Ingelheim Investigational Site | Brentwood | Tennessee |
| United States | 205.452.01163 Boehringer Ingelheim Investigational Site | Bronxville | New York |
| United States | 205.452.01347 Boehringer Ingelheim Investigational Site | Brownsburg | Indiana |
| United States | 205.452.01101 Boehringer Ingelheim Investigational Site | Burlington | North Carolina |
| United States | 205.452.01076 Boehringer Ingelheim Investigational Site | Butte | Montana |
| United States | 205.452.01264 Boehringer Ingelheim Investigational Site | Calabash | North Carolina |
| United States | 205.452.01193 Boehringer Ingelheim Investigational Site | Canal Fulton | Ohio |
| United States | 205.452.01143 Boehringer Ingelheim Investigational Site | Carnegie | Pennsylvania |
| United States | 205.452.01374 Boehringer Ingelheim Investigational Site | Centerville | Ohio |
| United States | 205.452.01218 Boehringer Ingelheim Investigational Site | Chandler | Arizona |
| United States | 205.452.01066 Boehringer Ingelheim Investigational Site | Charleston | South Carolina |
| United States | 205.452.01168 Boehringer Ingelheim Investigational Site | Charlotte | North Carolina |
| United States | 205.452.01205 Boehringer Ingelheim Investigational Site | Chaska | Minnesota |
| United States | 205.452.01220 Boehringer Ingelheim Investigational Site | Chattanooga | Tennessee |
| United States | 205.452.01324 Boehringer Ingelheim Investigational Site | Chattanooga | Tennessee |
| United States | 205.452.01365 Boehringer Ingelheim Investigational Site | Chelsea | Michigan |
| United States | 205.452.01014 Boehringer Ingelheim Investigational Site | Chesterfield | Missouri |
| United States | 205.452.01149 Boehringer Ingelheim Investigational Site | Chesterfield | Michigan |
| United States | 205.452.01278 Boehringer Ingelheim Investigational Site | Chicago | Illinois |
| United States | 205.452.01006 Boehringer Ingelheim Investigational Site | Cincinnati | Ohio |
| United States | 205.452.01373 Boehringer Ingelheim Investigational Site | Cincinnati | Ohio |
| United States | 205.452.01011 Boehringer Ingelheim Investigational Site | Clearwater | Florida |
| United States | 205.452.01314 Boehringer Ingelheim Investigational Site | Cleveland | Ohio |
| United States | 205.452.01059 Boehringer Ingelheim Investigational Site | Coeur d'Alene | Idaho |
| United States | 205.452.01049 Boehringer Ingelheim Investigational Site | Colorado Springs | Colorado |
| United States | 205.452.01245 Boehringer Ingelheim Investigational Site | Colorado Springs | Colorado |
| United States | 205.452.01217 Boehringer Ingelheim Investigational Site | Columbia | South Carolina |
| United States | 205.452.01210 Boehringer Ingelheim Investigational Site | Columbus | Ohio |
| United States | 205.452.01232 Boehringer Ingelheim Investigational Site | Columbus | Ohio |
| United States | 205.452.01255 Boehringer Ingelheim Investigational Site | Columbus | Georgia |
| United States | 205.452.01012 Boehringer Ingelheim Investigational Site | Conyers | Georgia |
| United States | 205.452.01194 Boehringer Ingelheim Investigational Site | Cooperstown | New York |
| United States | 205.452.01050 Boehringer Ingelheim Investigational Site | Corsicana | Texas |
| United States | 205.452.01189 Boehringer Ingelheim Investigational Site | Corvallis | Oregon |
| United States | 205.452.01284 Boehringer Ingelheim Investigational Site | Council Bluffs | Iowa |
| United States | 205.452.01267 Boehringer Ingelheim Investigational Site | Cranston | Rhode Island |
| United States | 205.452.01233 Boehringer Ingelheim Investigational Site | Dallas | Texas |
| United States | 205.452.01334 Boehringer Ingelheim Investigational Site | Dallas | Texas |
| United States | 205.452.01199 Boehringer Ingelheim Investigational Site | Danbury | Connecticut |
| United States | 205.452.01065 Boehringer Ingelheim Investigational Site | Danville | Virginia |
| United States | 205.452.01285 Boehringer Ingelheim Investigational Site | Danville | Virginia |
| United States | 205.452.01309 Boehringer Ingelheim Investigational Site | Dayton | Ohio |
| United States | 205.452.01140 Boehringer Ingelheim Investigational Site | Delaware | Ohio |
| United States | 205.452.01351 Boehringer Ingelheim Investigational Site | Denver | Colorado |
| United States | 205.452.01146 Boehringer Ingelheim Investigational Site | Detroit | Michigan |
| United States | 205.452.01371 Boehringer Ingelheim Investigational Site | Downer Grove | Illinois |
| United States | 205.452.01320 Boehringer Ingelheim Investigational Site | Downingtown | Pennsylvania |
| United States | 205.452.01021 Boehringer Ingelheim Investigational Site | Dubuque | Iowa |
| United States | 205.452.01062 Boehringer Ingelheim Investigational Site | Eagle | Idaho |
| United States | 205.452.01303 Boehringer Ingelheim Investigational Site | Easley | South Carolina |
| United States | 205.452.01211 Boehringer Ingelheim Investigational Site | Edina | Minnesota |
| United States | 205.452.01108 Boehringer Ingelheim Investigational Site | Elizabeth City | North Carolina |
| United States | 205.452.01190 Boehringer Ingelheim Investigational Site | Elkridge | Maryland |
| United States | 205.452.01131 Boehringer Ingelheim Investigational Site | Elmira | New York |
| United States | 205.452.01038 Boehringer Ingelheim Investigational Site | Encinitas | California |
| United States | 205.452.01142 Boehringer Ingelheim Investigational Site | Endwell | New York |
| United States | 205.452.01323 Boehringer Ingelheim Investigational Site | Erie | Pennsylvania |
| United States | 205.452.01045 Boehringer Ingelheim Investigational Site | Ettrick | Virginia |
| United States | 205.452.01153 Boehringer Ingelheim Investigational Site | Evansville | Indiana |
| United States | 205.452.01366 Boehringer Ingelheim Investigational Site | Fall River | Massachusetts |
| United States | 205.452.01301 Boehringer Ingelheim Investigational Site | Fishers | Indiana |
| United States | 205.452.01198 Boehringer Ingelheim Investigational Site | Florence | Alabama |
| United States | 205.452.01259 Boehringer Ingelheim Investigational Site | Florence | South Carolina |
| United States | 205.452.01018 Boehringer Ingelheim Investigational Site | Fort Collins | Colorado |
| United States | 205.452.01206 Boehringer Ingelheim Investigational Site | Fort Mitchell | Kentucky |
| United States | 205.452.01057 Boehringer Ingelheim Investigational Site | Fort Worth | Texas |
| United States | 205.452.01181 Boehringer Ingelheim Investigational Site | Fort Worth | Texas |
| United States | 205.452.01272 Boehringer Ingelheim Investigational Site | Fort Worth | Texas |
| United States | 205.452.01313 Boehringer Ingelheim Investigational Site | Fountain Valley | California |
| United States | 205.452.01375 Boehringer Ingelheim Investigational Site | Fountain Valley | California |
| United States | 205.452.01141 Boehringer Ingelheim Investigational Site | Franklin | Indiana |
| United States | 205.452.01187 Boehringer Ingelheim Investigational Site | Fremont | Nebraska |
| United States | 205.452.01104 Boehringer Ingelheim Investigational Site | Fridley | Minnesota |
| United States | 205.452.01074 Boehringer Ingelheim Investigational Site | Fullerton | California |
| United States | 205.452.01013 Boehringer Ingelheim Investigational Site | Gaffney | South Carolina |
| United States | 205.452.01299 Boehringer Ingelheim Investigational Site | Gainesville | Georgia |
| United States | 205.452.01192 Boehringer Ingelheim Investigational Site | Glens Falls | New York |
| * Note: There are 1191 locations in all - only the first 1000 are shown. | |||
| Lead Sponsor | Collaborator |
|---|---|
| Boehringer Ingelheim |
United States, Argentina, Australia, Austria, Belgium, Brazil, Bulgaria, Canada, China, Colombia, Croatia, Denmark, Finland, France, Georgia, Germany, Greece, Guatemala, Hungary, India, Ireland, Israel, Italy, Korea, Republic of, Latvia, Lithuania, Malaysia, Mexico, Netherlands, New Zealand, Norway, Panama, Peru, Philippines, Poland, Portugal, Puerto Rico, Romania, Russian Federation, Serbia, Slovakia, South Africa, Spain, Sweden, Switzerland, Taiwan, Thailand, Tunisia, Turkey, Ukraine, United Kingdom,
| Type | Measure | Description | Time frame | Safety issue |
|---|---|---|---|---|
| Primary | Time to All-Cause Mortality | Number of patients with all-cause mortality | Up to 3 years | No |
| Primary | Time to First COPD Exacerbation | Defined as "a complex of lower respiratory events/symptoms (increase of new onset) related to the underlying COPD, with duration of three days or more, requiring a change in treatment" where a "complex of lower respiratory event/symptoms" was defined as having at least two of the following: shortness of breath, sputum production (volume), occurrence of purulent sputum, cough, wheezing, chest tightness and where "a required change in treatment" includes the following:Prescription of antibiotics and/or systemic steroids, and/or a newly prescribed maintenance respiratory medication (i.e., bronchodilators including theophyllines). "Onset of exacerbation" was defined by the onset of first recorded symptom. The "end of exacerbation" was decided by the investigator based on clinical judgement. Exacerbations were classified as follows: Mild:a new prescription of maintenance bronchodilator only Moderate:antibiotics or systemic steroids without hospitalization Severe:hospitalization. |
Up to 3 years | No |
| Secondary | Trough FEV1 Over 120 Weeks (in a Substudy of 1370 Patients) | Trough forced expiratory volume in one second (FEV1) over 120 weeks (in a substudy of 1370 patients) | Up to 3 years | No |
| Secondary | Number of COPD Exacerbations | The number of COPD exacerbations. COPD exacerbation defined as "a complex of lower respiratory events/symptoms (increase of new onset) related to the underlying COPD, with duration of three days or more, requiring a change in treatment" where a "complex of lower respiratory event/symptoms" was defined as having at least two of the following: shortness of breath, sputum production (volume), occurrence of purulent sputum, cough, wheezing, chest tightness and where "a required change in treatment" includes the following:Prescription of antibiotics and/or systemic steroids, and/or a newly prescribed maintenance respiratory medication (i.e., bronchodilators including theophyllines). | Up to 3 years | No |
| Secondary | Time to First Hospitalization Associated With COPD Exacerbation | The results presented below are for the patients with hospitalizations due to COPD exacerbations. | Up to 3 years | No |
| Secondary | Number of Hospitalizations Associated With COPD Exacerbation | Total number of hospitalizations associated with COPD exacerbation. | Up to 3 years | No |
| Secondary | Time to First Moderate to Severe COPD Exacerbation | COPD exacerbation defined as "a complex of lower respiratory events/symptoms (increase of new onset) related to the underlying COPD, with duration of three days or more, requiring a change in treatment" where a "complex of lower respiratory event/symptoms" was defined as having at least two of the following: shortness of breath, sputum production (volume), occurrence of purulent sputum, cough, wheezing, chest tightness and where "a required change in treatment" includes the following:Prescription of antibiotics and/or systemic steroids, and/or a newly prescribed maintenance respiratory medication (i.e., bronchodilators including theophyllines). Exacerbations classified as follows: Mild:a new prescription of maintenance bronchodilator only Moderate:antibiotics or systemic steroids without hospitalization Severe:hospitalization. Results presented below are number of patients with moderate to severe exacerbations. |
Up to 3 years | No |
| Secondary | Time to Onset of First Major Adverse Cardiovascular Event (MACE) | Time to onset of first major adverse cardiovascular event (MACE). MACE was defined as: Fatal event in the system organ classes of cardiac and vascular disorders, Preferred terms: sudden death, cardiac death, sudden cardiac death, Outcome events of myocardial infarction (serious and non-serious), Outcome events of stroke (serious and non-serious) and Outcome events of TIA (serious and non-serious). The results presented below are for the number of patients with MACE. | Up to 3 years | No |
| Secondary | Time to Death From Major Adverse Cardiovascular Event (MACE) | The results presented below are number of patients with death from MACE. | Up to 3 years | No |
| Status | Clinical Trial | Phase | |
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Early Phase 1 | |
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Phase 4 | |
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Phase 4 | |
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Phase 3 | |
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Phase 3 | |
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Phase 2 | |
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NCT02853123 -
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Phase 4 | |
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Phase 1 | |
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NCT05858463 -
High Intensity Interval Training and Muscle Adaptations During PR
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N/A | |
| Not yet recruiting |
NCT05032898 -
Acute Exacerbation of Chronic Obstructive Pulmonary Disease Inpatient Registry Study Stage II
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