ADHD - Voice Analysis, Vocal Acoustic Biomarkers in Attention Deficit Hyperactivity Disorder

Attention-Deficit/Hyperactivity Disorder Clinical Trial

— ADHD  

Official title:

Phase 1 Study of Vocal Acoustic Biomarkers in Attention Deficit Hyperactivity Disorder (ADHD)

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT01104623
• Other study ID #: AiF KF2247401-AK9-1
• Status: Recruiting
• Phase: N/A
• First received: April 14, 2010
• Last updated: February 7, 2012
• Start date: April 2010
• Est. completion date: December 2012

Study information

• Verified date: February 2012
• Source: Charite University, Berlin, Germany
• Contact: n/a
• Is FDA regulated: No
• Health authority: Germany: Ethics Commission
• Study type: Observational

Clinical Trial Summary

The purpose of this study is to detect specific vocal acoustic patterns in the voice of attention deficit hyperactivity disorder (ADHD) patients.

Description:

This project aims to develop an objective diagnostic instrument for ADHD through an automatic voice-analysis system, which uses as input the natural speech of the participants. The underlying voice-analysis procedure was developed by J. Langner at Humboldt University of Berlin (Langner 2003). It ignores the semantic content of spoken words and extracts prosodic and sound features from the speech.

Aims of the study:

• deliver optimized multivariate logistic regression models of prosodic and sound properties of speech for ADHD.

• observe sensitivity and specificity of the voice-analysis procedure.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 400
• Est. completion date: December 2012
• Est. primary completion date: November 2012
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Both
• Age group: 18 Years to 50 Years

Eligibility

Inclusion Criteria:

1. Age 18-50.

2. Written informed consent.

3. Adult ADHD / Non-ADHD according to the fourth version of the Diagnostic and Statistical Manual for Mental Disorders (DSM-IV)

4. Normal vocal functioning, negative history for voice or laryngeal disorders.

5. Currently euthyroid condition; in case of past history of thyroid disease and need for current pharmacological treatment, patient needs to be on stable medication for at least 4 weeks.

Exclusion Criteria:

1. Exclusion of borderline and antisocial personality disorder, assessed by the German version of the SCID-II (Fydrich et al., 1997).

2. Exclusion of schizophrenia and psychotic disorders not otherwise specified.

3. Exclusion of Epilepsia.

Study Design

Observational Model: Cohort, Time Perspective: Prospective

Related Conditions & MeSH terms

• Attention Deficit Disorder with Hyperactivity
• Attention-Deficit/Hyperactivity Disorder
• Hyperkinesis

Locations

Country	Name	City	State
Germany	Center for ADHD Research, Department of Psychiatry, Charite - University Medicine	Berlin

Sponsors (3)

Lead Sponsor	Collaborator
Charite University, Berlin, Germany	AudioProfiling, Dr. Joerg Langner, MediTECH Electronic GmbH

Country where clinical trial is conducted

Germany, 

References & Publications (2)

Banse R, Scherer KR. Acoustic profiles in vocal emotion expression. J Pers Soc Psychol. 1996 Mar;70(3):614-36. — View Citation

Hamdan AL, Deeb R, Sibai A, Rameh C, Rifai H, Fayyad J. Vocal characteristics in children with attention deficit hyperactivity disorder. J Voice. 2009 Mar;23(2):190-4. Epub 2007 Dec 21. — View Citation

External Links

•   ADHD - Voice Analysis