Cervical Spondylosis Clinical Trial
Official title:
Open Labelled Study of Pregabalin in the Treatment of Neuropathic Pain in Cervical Myeloradiculopathy (Pregabalin and Radicular Pain Study (PARPS))
This study is designed to investigate the effectiveness of pregabalin (Lyrica) on nerve pain caused by degenerative neck problems. Pregabalin is a new drug registered for use in nerve pain worldwide
The treatment of neuropathic pain is clinically challenging, and pain from cervical
spondylosis (CS) is a common variant. This may result from degenerative spinal canal/cord
stenosis (cervical spondylotic myelopathy (CSM)) or lateral recesses compromise, leading to
nerve root compression (cervical spondylotic radiculopathy (CSR)).
Pregabalin is a newly registered drug for the treatment of neuropathic pain. Its efficacy
has been proven in randomised, placebo-controlled trials for post-herpetic neuralgia and
diabetic neuropathy. However, its efficacy in CS with underlying CSR or CSM has not been
established. Additionally, there are no data to date on its use in Asian patients.
In this study, we prospectively evaluate its efficacy for treating neuropathic pain in
degenerative CSR/ CSM 60 patients in an open-labelled, add on fashion. Self-evaluation and
investigator rated scoring will be implemented.
The results will be of value in the non-operative management of CS.
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Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
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