The Effect of Methylphenidate on Decision-making Ability of Attention Deficit Hyperactivity Disorder (ADHD) Adults

Attention Deficit Hyperactivity Disorder Clinical Trial

Official title:

The Effect of Methylphenidate on Decision-making Ability of ADHD Adults

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01040702
• Other study ID #: SH-40107
• Status: Completed
• Phase: Phase 1
• First received: December 29, 2009
• Last updated: December 29, 2009
• Start date: January 2008
• Est. completion date: December 2009

Study information

• Verified date: December 2009
• Source: Shalvata Mental Health Center
• Contact: n/a
• Is FDA regulated: No
• Health authority: Israel: Ministry of Health
• Study type: Interventional

Clinical Trial Summary

The aim of the study is to assess the effect of Methylphenidate on cognitive performance and decision-making ability of ADHD adults, and to compare this effect to the effect on healthy control adults.

Description:

Two matched groups of adults - with and without ADHD diagnosis - will perform a battery of computerized tasks assessing sustained attention,working-memory,non-verbal IQ,and decision-making ability. In each group,half of the participants will perform the tasks after receiving a capsule containing methylphenidate (MPH), and the other half will perform the tasks after receiving placebo. Task performance measures will then be compared in order to assess the effect of MPH on these domains.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 58
• Est. completion date: December 2009
• Est. primary completion date: August 2009
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Both
• Age group: 21 Years to 50 Years

Eligibility

Inclusion Criteria:

• adults in the age of 21-50

Exclusion Criteria:

• pregnant or nursing women.

• people who suffer from a psychiatric disorder other than ADHD which could account for their inattention symptoms better than ADHD.

• people who lack judgment or are unable to communicate with the experimenters.

• people who are incapable of performing the computerized tasks due to sensory or motor disabilities.

Study Design

Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Basic Science

Related Conditions & MeSH terms

• Attention Deficit Disorder with Hyperactivity
• Attention Deficit Hyperactivity Disorder
• Hyperkinesis

Intervention

Drug:
• methylphenidate
a single doses of 10-20 mg in each one of two visits

Dietary Supplement:
• sweetener pill
a capsule containing a sweetener pill

Locations

Country	Name	City	State
Israel	cognitive laboratory,Shalvata MHC	Hod Hasharon

Sponsors (1)

Lead Sponsor	Collaborator
Shalvata Mental Health Center

Country where clinical trial is conducted

Israel, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	score in decision-making task 1		by the end of the task	No
Secondary	working memory task score		by the end of the task	No