Investigation of Genetic Disease Marker Associated With Korean Glaucoma Patients

Single-nucleotide Polymorphism (SNP) for Glaucoma Clinical Trial

Official title:

Investigation of Genetic Disease Marker Associated With Korean Glaucoma Patients Patients, A Single-nucleotide Polymorphism(SNP)Analysis for Primary Open Angle Glaucoma

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01025024
• Other study ID #: CNUH81510-886
• Secondary ID: A080587
• Status: Completed
• Phase: N/A
• First received: December 2, 2009
• Last updated: December 2, 2009
• Start date: January 2007
• Est. completion date: November 2009

Study information

• Verified date: December 2009
• Source: Chungnam National University
• Contact: n/a
• Is FDA regulated: No
• Health authority: South Korea: Korea Food and Drug Administration (KFDA)
• Study type: Observational

Clinical Trial Summary

A single-nucleotide polymorphism (SNP) analysis of DNA obtained from peripheral blood of the glaucoma patients and the normal control will be performed to find genetic marker for primary open angle glaucoma.

Description:

Unrelated Korean subjects who have primary open angle glaucoma were recruited in the current study. Genotyping for various SNP associated with POAG due to the linkage disequilibrium patterns is to be performed. Genotypes would be statistically compared between patients with primary open angle glaucoma and normal control subjects free of any eye diseases.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 1224
• Est. completion date: November 2009
• Est. primary completion date: October 2009
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Both
• Age group: 30 Years and older

Eligibility

Inclusion Criteria:

• Clinical diagnosis of primary open angle glaucoma

Exclusion Criteria:

• Primary open angle glaucoma combined with congenital ocular disease

• Primary open angel glaucoma combined with other ocular disease

• Significant systemic disease other than systemic hypertension and diabetes

Study Design

Observational Model: Case Control, Time Perspective: Prospective

Related Conditions & MeSH terms

• Glaucoma
• Single-nucleotide Polymorphism (SNP) for Glaucoma

Intervention

Genetic:
• SNP analysis of the DNA
SNP analysis of the DNA obtained from peripheral blood sample

Locations

Country	Name	City	State
Korea, Republic of	Chungnam National University Hospital	Daejeon

Sponsors (3)

Lead Sponsor	Collaborator
Chungnam National University	Korea Advanced Institute of Science and Technology, Korea Healthcare Technology R&D Project

Country where clinical trial is conducted

Korea, Republic of, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	genotyping for the SNP associated with primary open angle glaucoma		one year	No
Secondary	genotyping for rs7961953 and additional SNPs in TMTC2 from other linkage disequilibrium patterns		one year	No