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INFLACOR - Clinical and Genetic Predictors of Inflammation Related Complications After Heart Surgery — INFLACOR  

Systemic Inflammatory Response Syndrome Clinical Trial

Official title:
INFLACOR (INFLA-mmation A-fter C-ardiac O-pe-R-ation) - Use of Selected Genetic Variants, Cytokines, and Physiologic Parameters in the Prognosis of Postoperative Complications in Patients Undergoing Cardiopulmonary Bypass Cardiac Surgery

Clinical Trial Summary

The aim of the study is to evaluate a clinically and economically most effective diagnostic algorithm for prediction of inflammatory response related complications in patients undergoing heart surgery with use of cardiopulmonary bypass.

Clinical Trial Description

Identified so far predictors of mortality and/or morbidity in patients who undergo heart surgery with cardiopulmonary bypass (CPB), used in previous risk prediction models (EUROSCORE, CABDEAL, Cleveland), will be compared with new candidate variables:

1. anamnestic: recent tooth extractions, chronic inflammatory diseases, specific drug use;

2. biochemical: C-reacting protein, interleukin-6, tumor necrosing factor alpha;

3. genetical: single nucleotide polymorphisms of 10 genes associated with inflammatory response; and

4. clinical from the 1. postoperative day: systemic inflammatory response syndrome, APACHE-III score;

against their predictive capability of selected clinical phenotypes of inflammatory response occuring after surgery, beginning from day 2. after surgery. ;

Study Design

Observational Model: Cohort, Time Perspective: Prospective

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01020409
Study type Observational
Source Medical University of Gdansk
Contact
Status Completed
Phase Phase 4
Start date October 2009
Completion date November 2012
View Details
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