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NCT00969605 Clinical Trial

Adaptive Support Ventilation in the Weaning of COPD

Pulmonary Disease, Chronic Obstructive Clinical Trial

Official title:
Adaptive Support Ventilation for Faster Weaning in COPD: A Randomized Controlled Trial

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT00969605
Other study ID # IGCEH-ICU-1
Secondary ID
Status Completed
Phase Phase 4
First received August 31, 2009
Last updated May 26, 2010
Start date April 2007
Est. completion date December 2008

Study information
Verified date September 2009
Source Izmir Dr Suat Seren Chest Diseases and Surgery Education and Research Hospital
Contact n/a
Is FDA regulated No
Health authority Turkey: Ministry of Health
Study type Interventional

Clinical Trial Summary

Adaptive support ventilation (ASV) is a closed loop ventilation mode that can act both as pressure support (PSV) and pressure controlled (PCV) ventilation. Weaning with ASV shows promising results mainly in post-cardiac surgery patients. The aim of this randomized controlled study was to test the hypothesis that weaning with ASV could reduce the weaning duration in patients with chronic obstructive pulmonary disease (COPD) when compared with PSV.

Recruitment information / eligibility
Status Completed
Enrollment 97
Est. completion date December 2008
Est. primary completion date May 2008
Accepts healthy volunteers No
Gender Both
Age group 18 Years and older
Eligibility Inclusion Criteria:

- Diagnosis of COPD

- On invasive mechanical ventilation for at least 24 hours because of hypoxemic and/or hypercapnic respiratory failure

Exclusion Criteria:

- Mechanical ventilation less then 24 hours (self extubation or death),

- Having a tracheotomy and

- COPD coexisted with severe cardiac or neurologic diseases.

Study Design

Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Subject), Primary Purpose: Screening

Related Conditions & MeSH terms

Intervention

Procedure:
• Comparison of two different modes for weaning from mechanical ventilation
Chronic obstructive pulmonary disease patients under mechanical ventilation were randomized to adaptive or pressure support ventilation modes when they met the weaning criteria.

Locations
Country Name City State
Turkey Izmir Dr Suat Seren Chest Diseases and Surgery Education and Research Hospital, Intensive Care Unit Izmir

Sponsors (1)
Lead Sponsor Collaborator
Izmir Dr Suat Seren Chest Diseases and Surgery Education and Research Hospital

Country where clinical trial is conducted

Turkey, 

Outcome
Type Measure Description Time frame Safety issue
Primary Weaning duration Yes
Secondary Weaning success Yes
Secondary Length of stay in the ICU No
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