Mild to Moderate Diabetic Sensorimotor Polyneuropathy Clinical Trial
Official title:
A 2-year, Randomized, Double-blind, Placebo-controlled, Multi-center, Phase II-III Study to Evaluate the Efficacy and Safety of Oral Ranirestat (40 and 80 mg) in Mild to Moderate Diabetic Sensorimotor Polyneuropathy
| Verified date | November 2015 |
| Source | Eisai Inc. |
| Contact | n/a |
| Is FDA regulated | No |
| Health authority | |
| Study type | Interventional |
The purpose of this study is to determine the effect of 40 mg and 80 mg ranirestat on peroneal motor nerve conduction velocity relative to placebo in subjects with mild to moderate diabetic sensorimotor polyneuropathy.
| Status | Completed |
| Enrollment | 800 |
| Est. completion date | February 2013 |
| Est. primary completion date | January 2013 |
| Accepts healthy volunteers | No |
| Gender | All |
| Age group | 18 Years to 75 Years |
| Eligibility |
Inclusion Criteria: - Subjects with Type 1 or Type 2, insulin-dependent or non insulin-dependent diabetes mellitus. - Subjects with a history of distal symmetric polyneuropathy, secondary to diabetes, diagnosed in accordance with the American Academy of Neurology criteria. - Female subjects, who are of non-reproductive potential (>=12 months post-menopausal or surgically sterile) or who are using adequate contraception which includes abstinence or double barrier methods (diaphragm and condom with spermicidal cream, intrauterine device and condom with spermicidal cream). Male subjects with partners of child-bearing potential must also use adequate contraception. - Subjects must be able to read, understand, and provide written informed consent before enrolling in the study at screening. Exclusion Criteria: - History of diabetic foot ulcers or lower extremity amputation. - Diabetic amyotrophy or non-diabetic cause of lower limb neuropathy/neuropathic symptoms. - Clinically significant illness which, in the opinion of the investigator, would compromise a subject's suitability to participate in the study for reasons of safety or would confound the efficacy assessments. |
| Country | Name | City | State |
|---|---|---|---|
| United States | The Johns Hopkins Hospital | Baltimore | Maryland |
| Lead Sponsor | Collaborator |
|---|---|
| Eisai Inc. |
United States,
| Type | Measure | Description | Time frame | Safety issue |
|---|---|---|---|---|
| Primary | Peroneal motor nerve conduction velocity: the mean of duplicate bilateral recordings made within 1-21 days of each other. | 24 months | ||
| Secondary | Neuropathy total symptom score-6 via a self-administered questionnaire and vibration perception threshold recorded with a neurothesiometer. | 24 months |