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NCT00898794 Clinical Trial

Effect of Bevacizumab and VEGF on Platelet Clustering in Patients Who Are Receiving Bevacizumab for Cancer

Unspecified Adult Solid Tumor, Protocol Specific Clinical Trial

Official title:
Influence of Bevacizumab and VEGF on Platelet Aggregation

Clinical Trial Details — Status: Recruiting

Administrative data
NCT number NCT00898794
Other study ID # KSGR-GR-01-07
Secondary ID CDR0000631252
Status Recruiting
Phase N/A
First received May 9, 2009
Last updated August 6, 2013
Start date October 2007

Study information
Verified date June 2011
Source National Cancer Institute (NCI)
Contact n/a
Is FDA regulated No
Health authority Unspecified
Study type Observational

Clinical Trial Summary

RATIONALE: Studying samples of blood from patients with cancer in the laboratory may help doctors learn more about the effect of bevacizumab and VEGF on platelet clustering.

PURPOSE: This research study is looking at the effect of bevacizumab and VEGF on platelet clustering in patients with cancer who are receiving bevacizumab.

Description:

OBJECTIVES:

- To determine the influence of bevacizumab on platelet aggregation in patients receiving bevacizumab for cancer.

- To determine the influence of VEGF on platelet aggregation.

- To determine the influence of VEGF or bevacizumab on cyclooxygenesis.

- To determine if the sequence of medication plays a role in platelet aggregation.

OUTLINE: Blood samples are collected before and after bevacizumab infusion. Samples are analyzed for measurements of platelet aggregation, coagulation parameters, and endothelial activation (e.g., fibrin fragment F1 and 2, thrombin and antithrombin complex, soluble P-selectin, Von Willebrand factor and factor VIII, tissue factor, and endothelin 1).

Recruitment information / eligibility
Status Recruiting
Enrollment 20
Est. completion date
Est. primary completion date May 2009
Accepts healthy volunteers No
Gender Both
Age group N/A and older
Eligibility DISEASE CHARACTERISTICS:

- Receiving bevacizumab for cancer

PATIENT CHARACTERISTICS:

- Not specified

PRIOR CONCURRENT THERAPY:

- See Disease Characteristics

Study Design

N/A

Related Conditions & MeSH terms

  • Unspecified Adult Solid Tumor, Protocol Specific
  • Unspecified Childhood Solid Tumor, Protocol Specific

Intervention

Biological:
• bevacizumab

Other:
• coagulation study

• laboratory biomarker analysis

• platelet aggregation test

Locations
Country Name City State
Switzerland Kantonsspital Graubuenden Chur

Sponsors (1)
Lead Sponsor Collaborator
Kantonsspital Graubuenden

Country where clinical trial is conducted

Switzerland, 

Outcome
Type Measure Description Time frame Safety issue
Primary Influence of bevacizumab on platelet aggregation No
Primary Influence of VEGF on platelet aggregation No
Primary Influence of VEGF or bevacizumab on cyclooxygenesis No
Primary Correlation between medication sequence and platelet aggregation No
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