Unspecified Adult Solid Tumor, Protocol Specific Clinical Trial
Official title:
Influence of Bevacizumab and VEGF on Platelet Aggregation
RATIONALE: Studying samples of blood from patients with cancer in the laboratory may help
doctors learn more about the effect of bevacizumab and VEGF on platelet clustering.
PURPOSE: This research study is looking at the effect of bevacizumab and VEGF on platelet
clustering in patients with cancer who are receiving bevacizumab.
OBJECTIVES:
- To determine the influence of bevacizumab on platelet aggregation in patients receiving
bevacizumab for cancer.
- To determine the influence of VEGF on platelet aggregation.
- To determine the influence of VEGF or bevacizumab on cyclooxygenesis.
- To determine if the sequence of medication plays a role in platelet aggregation.
OUTLINE: Blood samples are collected before and after bevacizumab infusion. Samples are
analyzed for measurements of platelet aggregation, coagulation parameters, and endothelial
activation (e.g., fibrin fragment F1 and 2, thrombin and antithrombin complex, soluble
P-selectin, Von Willebrand factor and factor VIII, tissue factor, and endothelin 1).
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N/A
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