Lymphoma Clinical Trial
Official title:
Cytogenetic and Fluorescence In Situ Hybridization Studies in Multiple Myeloma
RATIONALE: Studying the chromosomes in samples of bone marrow and blood in the laboratory
from patients with cancer or other blood diseases may help doctors learn more about the
disease.
PURPOSE: This laboratory study is analyzing chromosomes in patients with newly diagnosed
multiple myeloma or other blood disease.
OBJECTIVES:
- Compare the frequency of deletion 13 as detected by fluorescence in situ hybridization
(FISH) and conventional cytogenetics in patients with newly diagnosed multiple myeloma
(MM) or other monoclonal gammopathies (MG).
- Examine the prognostic value of specific subsets of chromosome aberrations detected by
conventional cytogenetics and FISH in relation to event-free and overall survival in
these patients.
- Compare the prognostic value of cytogenetics and FISH with other MM and MG prognostic
factors in these patients.
- Correlate the presence of cytogenetic and FISH features with clinical
pathophysiological, cellular, or other molecular characteristics in these patients.
OUTLINE: Patients receive treatment as directed by the treatment clinical trial on which
they are registered. Patients undergo bone marrow or blood sample collection periodically
for conventional cytogenetic analysis and fluorescence in situ hybridization studies (FISH).
Samples are analyzed for deleted 13q/monosomy 13 and chromosomal abnormalities.
PROJECTED ACCRUAL: A total of 500 patients will be accrued for this study.
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