Recurrent Adult Acute Lymphoblastic Leukemia Clinical Trial
Official title:
A Children's Oncology Group Protocol for Collecting and Banking Relapsed Acute Lymphoblastic Leukemia Research Specimens
| Verified date | January 2020 |
| Source | Children's Oncology Group |
| Contact | n/a |
| Is FDA regulated | No |
| Health authority | |
| Study type | Observational |
This research study is collecting and storing samples of bone marrow and blood from patients with relapsed acute lymphoblastic leukemia or relapsed non-Hodgkin lymphoma. Collecting and storing samples of bone marrow and blood from patients with cancer to study in the laboratory may help doctors learn more about cancer and help predict the recurrence of cancer.
| Status | Completed |
| Enrollment | 811 |
| Est. completion date | December 31, 2019 |
| Est. primary completion date | December 31, 2019 |
| Accepts healthy volunteers | No |
| Gender | All |
| Age group | N/A to 30 Years |
| Eligibility |
Inclusion Criteria: - Diagnosis of acute lymphoblastic leukemia (ALL) or prior history of non-Hodgkin lymphoma - In first or subsequent marrow relapse with = 25% blasts in bone marrow and/or peripheral blood - Bone marrow and/or peripheral blood samples (= 5 mL) required at the time of diagnosis of relapse - No concurrent systemic antileukemic treatment administered for current relapse - Intrathecal chemotherapy allowed - On-therapy relapse allowed |
| Country | Name | City | State |
|---|---|---|---|
| Australia | Princess Margaret Hospital for Children | Perth | Western Australia |
| Canada | IWK Health Centre | Halifax | Nova Scotia |
| Canada | Kingston Health Sciences Centre | Kingston | Ontario |
| Canada | Children's Hospital | London | Ontario |
| Canada | Centre Hospitalier Universitaire Sainte-Justine | Montreal | Quebec |
| Canada | The Montreal Children's Hospital of the MUHC | Montreal | Quebec |
| Canada | Children's Hospital of Eastern Ontario | Ottawa | Ontario |
| Canada | Allan Blair Cancer Centre | Regina | Saskatchewan |
| Canada | Saskatoon Cancer Centre | Saskatoon | Saskatchewan |
| Canada | Hospital for Sick Children | Toronto | Ontario |
| Canada | British Columbia Children's Hospital | Vancouver | British Columbia |
| Canada | CancerCare Manitoba | Winnipeg | Manitoba |
| Puerto Rico | San Jorge Children's Hospital | San Juan | |
| Puerto Rico | University Pediatric Hospital | San Juan | |
| Switzerland | Swiss Pediatric Oncology Group - Bern | Bern | |
| United States | Children's Hospital Medical Center of Akron | Akron | Ohio |
| United States | Albany Medical Center | Albany | New York |
| United States | University of New Mexico Cancer Center | Albuquerque | New Mexico |
| United States | Texas Tech University Health Sciences Center-Amarillo | Amarillo | Texas |
| United States | Mission Hospital | Asheville | North Carolina |
| United States | Children's Healthcare of Atlanta - Egleston | Atlanta | Georgia |
| United States | Children's Hospital Colorado | Aurora | Colorado |
| United States | Johns Hopkins University/Sidney Kimmel Cancer Center | Baltimore | Maryland |
| United States | Sinai Hospital of Baltimore | Baltimore | Maryland |
| United States | University of Maryland/Greenebaum Cancer Center | Baltimore | Maryland |
| United States | Walter Reed National Military Medical Center | Bethesda | Maryland |
| United States | Lehigh Valley Hospital - Muhlenberg | Bethlehem | Pennsylvania |
| United States | Children's Hospital of Alabama | Birmingham | Alabama |
| United States | University of Alabama at Birmingham Cancer Center | Birmingham | Alabama |
| United States | Saint Luke's Mountain States Tumor Institute | Boise | Idaho |
| United States | Montefiore Medical Center - Moses Campus | Bronx | New York |
| United States | Roswell Park Cancer Institute | Buffalo | New York |
| United States | University of Vermont and State Agricultural College | Burlington | Vermont |
| United States | UNC Lineberger Comprehensive Cancer Center | Chapel Hill | North Carolina |
| United States | West Virginia University Charleston Division | Charleston | West Virginia |
| United States | Carolinas Medical Center/Levine Cancer Institute | Charlotte | North Carolina |
| United States | Novant Health Presbyterian Medical Center | Charlotte | North Carolina |
| United States | T C Thompson Children's Hospital | Chattanooga | Tennessee |
| United States | Lurie Children's Hospital-Chicago | Chicago | Illinois |
| United States | University of Chicago Comprehensive Cancer Center | Chicago | Illinois |
| United States | University of Illinois | Chicago | Illinois |
| United States | Cleveland Clinic Foundation | Cleveland | Ohio |
| United States | Rainbow Babies and Childrens Hospital | Cleveland | Ohio |
| United States | Columbia Regional | Columbia | Missouri |
| United States | Prisma Health Richland Hospital | Columbia | South Carolina |
| United States | Nationwide Children's Hospital | Columbus | Ohio |
| United States | Driscoll Children's Hospital | Corpus Christi | Texas |
| United States | Medical City Dallas Hospital | Dallas | Texas |
| United States | UT Southwestern/Simmons Cancer Center-Dallas | Dallas | Texas |
| United States | Dayton Children's Hospital | Dayton | Ohio |
| United States | Rocky Mountain Hospital for Children-Presbyterian Saint Luke's Medical Center | Denver | Colorado |
| United States | Blank Children's Hospital | Des Moines | Iowa |
| United States | Ascension Saint John Hospital | Detroit | Michigan |
| United States | Wayne State University/Karmanos Cancer Institute | Detroit | Michigan |
| United States | Kaiser Permanente Downey Medical Center | Downey | California |
| United States | City of Hope Comprehensive Cancer Center | Duarte | California |
| United States | Duke University Medical Center | Durham | North Carolina |
| United States | Michigan State University Clinical Center | East Lansing | Michigan |
| United States | Sanford Broadway Medical Center | Fargo | North Dakota |
| United States | Hurley Medical Center | Flint | Michigan |
| United States | Broward Health Medical Center | Fort Lauderdale | Florida |
| United States | Golisano Children's Hospital of Southwest Florida | Fort Myers | Florida |
| United States | Lee Memorial Health System | Fort Myers | Florida |
| United States | Brooke Army Medical Center | Fort Sam Houston | Texas |
| United States | Cook Children's Medical Center | Fort Worth | Texas |
| United States | University of Florida Health Science Center - Gainesville | Gainesville | Florida |
| United States | Helen DeVos Children's Hospital at Spectrum Health | Grand Rapids | Michigan |
| United States | Saint Vincent Hospital Cancer Center Green Bay | Green Bay | Wisconsin |
| United States | BI-LO Charities Children's Cancer Center | Greenville | South Carolina |
| United States | East Carolina University | Greenville | North Carolina |
| United States | Greenville Cancer Treatment Center | Greenville | South Carolina |
| United States | Hackensack University Medical Center | Hackensack | New Jersey |
| United States | Connecticut Children's Medical Center | Hartford | Connecticut |
| United States | Penn State Children's Hospital | Hershey | Pennsylvania |
| United States | Memorial Regional Hospital/Joe DiMaggio Children's Hospital | Hollywood | Florida |
| United States | Kapiolani Medical Center for Women and Children | Honolulu | Hawaii |
| United States | University of Hawaii Cancer Center | Honolulu | Hawaii |
| United States | Riley Hospital for Children | Indianapolis | Indiana |
| United States | Saint Vincent Hospital and Health Care Center | Indianapolis | Indiana |
| United States | University of Iowa/Holden Comprehensive Cancer Center | Iowa City | Iowa |
| United States | University of Mississippi Medical Center | Jackson | Mississippi |
| United States | Nemours Children's Clinic-Jacksonville | Jacksonville | Florida |
| United States | Bronson Methodist Hospital | Kalamazoo | Michigan |
| United States | Kalamazoo Center for Medical Studies | Kalamazoo | Michigan |
| United States | Children's Mercy Hospitals and Clinics | Kansas City | Missouri |
| United States | University of Kansas Cancer Center | Kansas City | Kansas |
| United States | East Tennessee Childrens Hospital | Knoxville | Tennessee |
| United States | Alliance for Childhood Diseases/Cure 4 the Kids Foundation | Las Vegas | Nevada |
| United States | Nevada Cancer Research Foundation CCOP | Las Vegas | Nevada |
| United States | Summerlin Hospital Medical Center | Las Vegas | Nevada |
| United States | Sunrise Hospital and Medical Center | Las Vegas | Nevada |
| United States | University Medical Center of Southern Nevada | Las Vegas | Nevada |
| United States | Dartmouth Hitchcock Medical Center | Lebanon | New Hampshire |
| United States | University of Kentucky/Markey Cancer Center | Lexington | Kentucky |
| United States | Arkansas Children's Hospital | Little Rock | Arkansas |
| United States | University of Arkansas for Medical Sciences | Little Rock | Arkansas |
| United States | Loma Linda University Medical Center | Loma Linda | California |
| United States | Miller Children's and Women's Hospital Long Beach | Long Beach | California |
| United States | Children's Hospital Los Angeles | Los Angeles | California |
| United States | UCLA / Jonsson Comprehensive Cancer Center | Los Angeles | California |
| United States | Norton Children's Hospital | Louisville | Kentucky |
| United States | Covenant Children's Hospital | Lubbock | Texas |
| United States | Valley Children's Hospital | Madera | California |
| United States | Marshfield Medical Center-Marshfield | Marshfield | Wisconsin |
| United States | Miami Cancer Institute | Miami | Florida |
| United States | University of Miami Miller School of Medicine-Sylvester Cancer Center | Miami | Florida |
| United States | Children's Hospital of Wisconsin | Milwaukee | Wisconsin |
| United States | Children's Hospitals and Clinics of Minnesota - Minneapolis | Minneapolis | Minnesota |
| United States | University of Minnesota/Masonic Cancer Center | Minneapolis | Minnesota |
| United States | Morristown Medical Center | Morristown | New Jersey |
| United States | Vanderbilt University/Ingram Cancer Center | Nashville | Tennessee |
| United States | Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital | New Brunswick | New Jersey |
| United States | Saint Peter's University Hospital | New Brunswick | New Jersey |
| United States | Children's Hospital New Orleans | New Orleans | Louisiana |
| United States | Ochsner Medical Center Jefferson | New Orleans | Louisiana |
| United States | Tulane University Health Sciences Center | New Orleans | Louisiana |
| United States | Laura and Isaac Perlmutter Cancer Center at NYU Langone | New York | New York |
| United States | NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center | New York | New York |
| United States | Newark Beth Israel Medical Center | Newark | New Jersey |
| United States | Children's Hospital of The King's Daughters | Norfolk | Virginia |
| United States | Advocate Children's Hospital-Oak Lawn | Oak Lawn | Illinois |
| United States | Children's Hospital and Research Center at Oakland | Oakland | California |
| United States | Kaiser Permanente-Oakland | Oakland | California |
| United States | University of Oklahoma Health Sciences Center | Oklahoma City | Oklahoma |
| United States | Children's Hospital and Medical Center of Omaha | Omaha | Nebraska |
| United States | University of Nebraska Medical Center | Omaha | Nebraska |
| United States | Children's Hospital of Orange County | Orange | California |
| United States | AdventHealth Orlando | Orlando | Florida |
| United States | Arnold Palmer Hospital for Children | Orlando | Florida |
| United States | Nemours Children's Clinic - Orlando | Orlando | Florida |
| United States | Nemours Children's Hospital | Orlando | Florida |
| United States | UF Cancer Center at Orlando Health | Orlando | Florida |
| United States | Lucile Packard Children's Hospital Stanford University | Palo Alto | California |
| United States | Advocate Children's Hospital-Park Ridge | Park Ridge | Illinois |
| United States | Advocate Lutheran General Hospital | Park Ridge | Illinois |
| United States | Saint Joseph's Regional Medical Center | Paterson | New Jersey |
| United States | Nemours Children's Clinic - Pensacola | Pensacola | Florida |
| United States | Saint Jude Midwest Affiliate | Peoria | Illinois |
| United States | Children's Hospital of Philadelphia | Philadelphia | Pennsylvania |
| United States | Childrens Oncology Group | Philadelphia | Pennsylvania |
| United States | Saint Christopher's Hospital for Children | Philadelphia | Pennsylvania |
| United States | Phoenix Childrens Hospital | Phoenix | Arizona |
| United States | Children's Hospital of Pittsburgh of UPMC | Pittsburgh | Pennsylvania |
| United States | Legacy Emanuel Children's Hospital | Portland | Oregon |
| United States | Legacy Emanuel Hospital and Health Center | Portland | Oregon |
| United States | Oregon Health and Science University | Portland | Oregon |
| United States | Rhode Island Hospital | Providence | Rhode Island |
| United States | Carilion Clinic Children's Hospital | Roanoke | Virginia |
| United States | Mayo Clinic | Rochester | Minnesota |
| United States | University of Rochester | Rochester | New York |
| United States | Sutter Medical Center Sacramento | Sacramento | California |
| United States | University of California Davis Comprehensive Cancer Center | Sacramento | California |
| United States | Mercy Hospital Saint Louis | Saint Louis | Missouri |
| United States | Washington University School of Medicine | Saint Louis | Missouri |
| United States | Johns Hopkins All Children's Hospital | Saint Petersburg | Florida |
| United States | Primary Children's Hospital | Salt Lake City | Utah |
| United States | Children's Hospital of San Antonio | San Antonio | Texas |
| United States | Methodist Children's Hospital of South Texas | San Antonio | Texas |
| United States | University of Texas Health Science Center at San Antonio | San Antonio | Texas |
| United States | Naval Medical Center -San Diego | San Diego | California |
| United States | Rady Children's Hospital - San Diego | San Diego | California |
| United States | UCSF Medical Center-Mission Bay | San Francisco | California |
| United States | UCSF Medical Center-Parnassus | San Francisco | California |
| United States | Seattle Children's Hospital | Seattle | Washington |
| United States | Sanford USD Medical Center - Sioux Falls | Sioux Falls | South Dakota |
| United States | Providence Sacred Heart Medical Center and Children's Hospital | Spokane | Washington |
| United States | Southern Illinois University School of Medicine | Springfield | Illinois |
| United States | Stony Brook University Medical Center | Stony Brook | New York |
| United States | Overlook Hospital | Summit | New Jersey |
| United States | State University of New York Upstate Medical University | Syracuse | New York |
| United States | Madigan Army Medical Center | Tacoma | Washington |
| United States | Mary Bridge Children's Hospital and Health Center | Tacoma | Washington |
| United States | Saint Joseph's Hospital/Children's Hospital-Tampa | Tampa | Florida |
| United States | Tampa General Hospital | Tampa | Florida |
| United States | Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center | Torrance | California |
| United States | Banner University Medical Center - Tucson | Tucson | Arizona |
| United States | New York Medical College | Valhalla | New York |
| United States | Children's National Medical Center | Washington | District of Columbia |
| United States | MedStar Georgetown University Hospital | Washington | District of Columbia |
| United States | Saint Mary's Hospital | West Palm Beach | Florida |
| United States | Alfred I duPont Hospital for Children | Wilmington | Delaware |
| United States | Wake Forest University Health Sciences | Winston-Salem | North Carolina |
| United States | UMass Memorial Medical Center - University Campus | Worcester | Massachusetts |
| Lead Sponsor | Collaborator |
|---|---|
| Children's Oncology Group | National Cancer Institute (NCI) |
United States, Australia, Canada, Puerto Rico, Switzerland,
| Type | Measure | Description | Time frame | Safety issue |
|---|---|---|---|---|
| Primary | Banking of tumor cells and germline DNA | Not Provided |
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Terminated |
NCT01564277 -
Rasburicase and Allopurinol in Treating Patients With Hematologic Malignancies
|
Phase 2 | |
| Completed |
NCT01527045 -
Donor Atorvastatin Treatment in Preventing Severe Acute GVHD After Nonmyeloablative Peripheral Blood Stem Cell Transplant in Patients With Hematological Malignancies
|
Phase 2 | |
| Terminated |
NCT02109224 -
Ibrutinib in Treating Relapsed or Refractory B-Cell Non-Hodgkin Lymphoma in Patients With HIV Infection
|
Phase 1 | |
| Completed |
NCT02168140 -
CPI-613 and Bendamustine Hydrochloride in Treating Patients With Relapsed or Refractory T-Cell Non-Hodgkin Lymphoma or Hodgkin Lymphoma
|
Phase 1 | |
| Completed |
NCT01427881 -
Cyclophosphamide for Prevention of Graft-Versus-Host Disease After Allogeneic Peripheral Blood Stem Cell Transplantation in Patients With Hematological Malignancies
|
Phase 2 | |
| Completed |
NCT01233921 -
Palifermin in Preventing Chronic Graft-Versus-Host Disease in Patients Who Have Undergone Donor Stem Cell Transplant for Hematologic Cancer
|
N/A | |
| Completed |
NCT01093586 -
Donor Umbilical Cord Blood Stem Cell Transplant in Treating Patients With Hematologic Malignancies
|
Phase 2 | |
| Terminated |
NCT00387426 -
Sunitinib in Treating Patients With Idiopathic Myelofibrosis
|
Phase 2 | |
| Completed |
NCT00078858 -
Mycophenolate Mofetil and Cyclosporine in Reducing Graft-Versus-Host Disease in Patients With Hematologic Malignancies or Metastatic Kidney Cancer Undergoing Donor Stem Cell Transplant
|
Phase 1/Phase 2 | |
| Completed |
NCT00052520 -
Biological Therapy in Treating Patients With Advanced Myelodysplastic Syndrome, Acute or Chronic Myeloid Leukemia, or Acute Lymphoblastic Leukemia Who Are Undergoing Stem Cell Transplantation
|
Phase 1/Phase 2 | |
| Completed |
NCT00031655 -
Reduced Intensity Donor Stem Cell Transplant in Treating Patients With High Risk Acute Lymphocytic Leukemia in Complete Remission
|
Phase 2 | |
| Completed |
NCT00003196 -
Low-Dose Total Body Irradiation and Donor Peripheral Blood Stem Cell Transplant Followed by Donor Lymphocyte Infusion in Treating Patients With Non-Hodgkin Lymphoma, Chronic Lymphocytic Leukemia, or Multiple Myeloma
|
N/A | |
| Active, not recruiting |
NCT00792948 -
Combination Chemotherapy With or Without Donor Stem Cell Transplant in Treating Patients With Acute Lymphoblastic Leukemia
|
Phase 2 | |
| Completed |
NCT01588015 -
Vaccine Therapy in Preventing Cytomegalovirus Infection in Patients With Hematological Malignancies Undergoing Donor Stem Cell Transplant
|
Phase 1 | |
| Withdrawn |
NCT02281279 -
Rituximab, Romidepsin, and Lenalidomide in Treating Patients With Recurrent or Refractory B-cell Non-Hodgkin Lymphoma
|
Phase 1/Phase 2 | |
| Terminated |
NCT01383447 -
Entinostat And Imatinib Mesylate In Treating Patients With Relapsed or Refractory Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia
|
Phase 1/Phase 2 | |
| Completed |
NCT00608361 -
Dasatinib in Treating Patients With Solid Tumors or Lymphomas That Are Metastatic or Cannot Be Removed By Surgery
|
Phase 1 | |
| Completed |
NCT00217646 -
Sorafenib in Treating Patients With Refractory or Relapsed Acute Leukemia, Myelodysplastic Syndromes, or Blastic Phase Chronic Myelogenous Leukemia
|
Phase 1 | |
| Completed |
NCT00095797 -
XK469R in Treating Patients With Refractory Hematologic Cancer
|
Phase 1 | |
| Terminated |
NCT00101231 -
Flavopiridol in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, or Chronic Myelogenous Leukemia
|
Phase 1 |