Pulmonary Disease, Chronic Obstructive Clinical Trial
Official title:
Specialized Center of Clinically Oriented Research: Alveolar and Airway Mechanisms of COPD. Airway Determinants: Innate Immune Signaling (Project 4)
NCT number | NCT00740337 |
Other study ID # | 582 |
Secondary ID | |
Status | Completed |
Phase | |
First received | |
Last updated | |
Start date | October 2007 |
Est. completion date | February 2016 |
Verified date | June 2018 |
Source | Washington University School of Medicine |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational |
Chronic obstructive pulmonary disease (COPD) is the fourth most common cause of death in the United States. There is no cure and the disease gets worse over time. Although it usually occurs in people who smoke cigarettes, researchers do not know exactly how smoking leads to COPD. This study will compare blood and tissue samples from smokers and nonsmokers with and without COPD to determine why some COPD symptoms occur in some people and not others.
Status | Completed |
Enrollment | 82 |
Est. completion date | February 2016 |
Est. primary completion date | February 2016 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years and older |
Eligibility |
Inclusion Criteria: - Ability to read and write in English - Able to participate in the informed consent process - Planned lung resection at BJH - Acceptable pulmonary function tests done at BJH within 1 month of enrollment - Acceptable chest CT scan done at BJH within 3 years of enrollment Exclusion Criteria: - Pregnant - Prisoner - Vulnerable populations - Clinically significant lung disease other than COPD and the indication for resection (e.g., cystic fibrosis, bronchiectasis, obliterative bronchiolitis, airway lesion) - Coexisting active chronic inflammatory or collagen vascular disease, immune deficiency of any kind, or previous organ transplant - Known active hepatitis B, hepatitis C, or HIV/AIDS (not prospectively evaluated) - Systemic chemotherapy within past 1 month (30 days) - Hematologic malignancy or thoracic radiation within past year |
Country | Name | City | State |
---|---|---|---|
United States | Washington University School of Medicine | Saint Louis | Missouri |
Lead Sponsor | Collaborator |
---|---|
Washington University School of Medicine |
United States,
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