Continuous Ambulatory Peritoneal Dialysis Clinical Trial
Official title:
Biomarker for Early Detection and Intervention of Peritoneal Ultrafiltration Failure
This study will examine the peritoneal tissue, serum and dialysate proteins of peritoneal
dialysis (PD) patients with different types of peritoneal solute transport by differential
proteomics techniques.
This study will be performed to identify the molecular difference between different types of
peritoneal solute transport and explore biomarker for early detection as well as early
intervention of peritoneal ultrafiltration failure.
Ultrafiltration failure (UFF) is an important cause of technical failure in PD patients. It
may develop over time and is, therefore, especially important in longterm PD. However, the
study on UFF is very limited so far, there are still lack of biomarker for early detection
and intervention of UFF.
Proteomics uses a rapidly evolving group of technologies to identify, quantify, and
characterize a global set of proteins. It is characterized by high-throughput, high
specificity and high-sensitivity. Therefore, proteomics has become a major focus of recent
medical research.
This study will examine the peritoneal tissue, serum and dialysate proteins of continuous
ambulatory peritoneal dialysis (CAPD) patients with different types of peritoneal solute
transport by differential proteomics techniques. Correlation analysis will be used for the
relationship between clinical data and the differential proteins, as well as verification of
the differential proteins in the peritoneal tissue, serum and dialysate of patients with
UFF. This study will be performed to identify the molecular difference between different
types of peritoneal solute transport and explore biomarker for early detection as well as
early intervention of peritoneal ultrafiltration failure.
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Observational Model: Case Control
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