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Clinical Trial Details — Status: Suspended

Administrative data

NCT number NCT00695032
Other study ID # 07GENE03
Secondary ID ICREGAUD-TOXIPLA
Status Suspended
Phase N/A
First received June 7, 2008
Last updated November 4, 2014
Start date October 2007

Study information

Verified date November 2014
Source Institut Claudius Regaud
Contact n/a
Is FDA regulated No
Health authority France: Agence Nationale de Sécurité du Médicament et des produits de santé
Study type Interventional

Clinical Trial Summary

RATIONALE: Studying samples of blood and urine from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. It may also help doctors predict how patients will respond to treatment.

PURPOSE: This research study is evaluating kidney damage in patients receiving cisplatin and ifosfamide for solid tumors.


Description:

OBJECTIVES:

Primary

- Identify and evaluate the early biomarkers of renal toxicity in patients with solid tumors treated with cisplatin and ifosfamide.

Secondary

- Correlate the modification of biomarker studies and blood concentrations of cisplatin.

OUTLINE: Patients receive standard chemotherapy comprising cisplatin and/or ifosfamide.

Blood and urine samples are collected on days 1 and 2 (or day 3 if receiving ifosfamide only) during the first 3 courses. Samples are analyzed to determine plasma concentrations of residual cisplatin and to obtain urinary-protein profiles to measure renal toxicity.


Recruitment information / eligibility

Status Suspended
Enrollment 80
Est. completion date
Est. primary completion date September 2012
Accepts healthy volunteers No
Gender Both
Age group 18 Years and older
Eligibility DISEASE CHARACTERISTICS:

- Diagnosis of a solid tumor

- Any location allowed

- Metastatic disease allowed

- Planned treatment comprising cisplatin and/or ifosfamide as standard chemotherapy

PATIENT CHARACTERISTICS:

Inclusion criteria:

- Life expectancy > 3 months

- Creatinine clearance = 60 mL/min

- Must be available for follow up

- Not pregnant or nursing

- Not under guardianship or in prison

Exclusion criteria:

- Prior drug-related nephrotoxicity

- Acute, uncontrolled urinary infection or > 48-hours

- Pre-existing hemorrhagic cystitis

- Weak bladder

- Bilateral obstruction of urinary tract

- Insufficient, severe bone marrow hypoplasia

- Cardiorespiratory condition contraindicating hyperhydration

- Hearing impairment

- Hypersensitivity to cisplatin or products containing platinum

- Major psychiatric condition (severe depression, psychosis, dementia)

PRIOR CONCURRENT THERAPY:

- No prior yellow fever vaccine, live attenuated vaccine, or phenytoin

- No concurrent participation in another biomedical study

Study Design

Allocation: Non-Randomized, Intervention Model: Parallel Assignment, Primary Purpose: Treatment


Related Conditions & MeSH terms


Intervention

Drug:
cisplatin

ifosfamide

Other:
laboratory biomarker analysis


Locations

Country Name City State
France Institut Claudius Regaud Toulouse

Sponsors (1)

Lead Sponsor Collaborator
Institut Claudius Regaud

Country where clinical trial is conducted

France, 

Outcome

Type Measure Description Time frame Safety issue
Primary Evolution of different biomarkers No
Primary Sensitivity, specificity, and predictive value (positive and negative) of different markers No
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