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Clinical Trial Summary

The purpose of this study is determine the highest dose of bortezomib, a new drug for graft-versus host disease prevention, that can be given in combination with sirolimus and Tacrolimus, without causing severe side effects. This research is being done because there is no treatment that is 100% effective in preventing graft versus host disease.

The goals of this study are to:

1. Collect peripheral blood stem cells (PBSCs) from donors for transplant.

2. Determine the largest possible dose of bortezomib that can be given to recipients with various blood cancers in a safe manner.

3. Monitor the recipient for risk of infection or side affects associated with the transplant.

4. Monitor the recipient for increased immunity following transplantation.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT00670423
Study type Interventional
Source Indiana University
Contact
Status Completed
Phase Phase 1
Start date May 16, 2008
Completion date October 16, 2013

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