Sorafenib Combined With Cisplatin and Etoposide or Carboplatin and Pemetrexed in Treating Patients With Metastatic Solid Tumors

Unspecified Adult Solid Tumor, Protocol Specific Clinical Trial

Official title:

A Two Arm Phase I Trial of Sorafenib in Combination With Cisplatin/Etoposide or Carboplatin/Pemetrexed in Patients With Solid Tumors

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00573690
• Other study ID #: LCCC 0613
• Secondary ID: CDR0000579819UNC
• Status: Completed
• Phase: Phase 1
• First received: December 13, 2007
• Last updated: April 20, 2012
• Start date: September 2007
• Est. completion date: February 2011

Study information

• Verified date: April 2012
• Source: UNC Lineberger Comprehensive Cancer Center
• Contact: n/a
• Is FDA regulated: No
• Health authority: United States: Federal Government
• Study type: Interventional

Clinical Trial Summary

RATIONALE: Sorafenib and pemetrexed may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Sorafenib may also stop the growth of tumor cells by blocking blood flow to the tumor. Drugs used in chemotherapy, such as cisplatin, etoposide, and carboplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving sorafenib together with cisplatin and etoposide or carboplatin and pemetrexed may kill more tumor cells.

PURPOSE: This phase I trial is studying the side effects and best dose of sorafenib when given together with cisplatin and etoposide or carboplatin and pemetrexed in treating patients with metastatic solid tumors.

Description:

OBJECTIVES:

Primary

• To determine the recommended phase II dose and maximum tolerated dose of sorafenib tosylate when administered in combination with cisplatin and etoposide or carboplatin and pemetrexed disodium in patients with metastatic solid tumors.

Secondary

• To characterize the toxicities of these regimens in these patients.

• To evaluate the efficacy of these regimens in these patients, as measured by RECIST criteria or by tumor markers, if applicable (e.g., PSA, CA-125).

• To determine the pharmacokinetics of sorafenib tosylate when administered in combination with etoposide in these patients (samples are no longer being collected and studies are no longer being performed as of 1/8/09).

OUTLINE: Patients are assigned to 1 of 2 treatment groups.

• Group 1: Patients receive cisplatin IV over 1 hour on day 2 of courses 1 and 2 and on day 1 of all subsequent courses; etoposide IV over 30 minutes on days 1-3; and oral sorafenib tosylate once or twice daily on days 1-21. Treatment repeats every 21 days in the absence of unacceptable toxicity or disease progression.

• Group 2: Patients receive carboplatin IV over 30 minutes and pemetrexed disodium IV over 10 minutes on day 1. Patients also receive sorafenib tosylate as in group 1. Treatment repeats every 21 days in the absence of unacceptable toxicity or disease progression.

Patients in group 1 undergo blood sample collection on day 1 of courses 1 and 2 for pharmacokinetic studies (samples are no longer being collected and studies are no longer being performed as of 1/8/09).

After finishing treatment, patients are followed at 30 days.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 31
• Est. completion date: February 2011
• Est. primary completion date: June 2009
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 18 Years and older

Eligibility

DISEASE CHARACTERISTICS:

• Histologically or cytologically confirmed metastatic solid tumor

• Disease progressed during at least one standard therapy OR has a disease for which there is no standard therapy

• No squamous cell carcinoma of the lung

• Asymptomatic brain metastases allowed provided both of the following criteria are met:

• Brain metastases were treated = 6 months ago

• Brain metastases are clinically stable without steroid treatment for 1 week

• No clinically relevant pleural effusions or ascites that cannot be controlled by drainage (group 2)

PATIENT CHARACTERISTICS:

• ECOG performance status 0-1

• Hemoglobin = 9.0 g/dL

• ANC = 1,500/mm³

• Platelet count = 100,000/mm³

• Total bilirubin = 1.5 times upper limit of normal (ULN)

• ALT and AST = 2.5 times ULN

• INR < 1.5 or PT/PTT normal

• Creatinine clearance = 45 mL/min

• Negative serum pregnancy test

• Fertile patients must use effective contraception during and for at least 2 weeks after completion of study treatment

• No New York Heart Association class III or IV congestive heart failure

• No unstable angina (anginal symptoms at rest) or new onset angina (within the past 3 months)

• No myocardial infarction within the past 6 months

• No cardiac ventricular arrhythmias requiring anti-arrhythmic therapy

• No uncontrolled hypertension, defined as systolic blood pressure > 150 mm Hg or diastolic blood pressure > 90 mm Hg, despite optimal medical management

• No known severe hypersensitivity to sorafenib tosylate or any its excipients, etoposide, pemetrexed disodium, cisplatin, or carboplatin

• No known HIV infection

• No chronic hepatitis B or C

• No active clinically serious infection > CTCAE grade 2

• No thrombotic or embolic events, such as cerebrovascular accident or transient ischemic attacks, within the past 6 months

• No pulmonary hemorrhage or bleeding event = CTCAE grade 2 within the past 4 weeks

• No other hemorrhage or bleeding event = CTCAE grade 3 within the past 4 weeks

• No serious non-healing wound, ulcer, or bone fracture

• No evidence or history of bleeding diathesis or coagulopathy

• No condition that impairs the patient's ability to swallow whole pills

• No malabsorption problem, uncontrolled inflammatory bowel disease, or gastrointestinal disorder causing = 5 bowel movements in a 24-hour period

• No significant traumatic injury within the past 4 weeks

• Able to take vitamin B12 supplementation and folic acid (group 2)

PRIOR CONCURRENT THERAPY:

• More than 4 weeks since prior major surgery or open biopsy

• No more than 3 prior cytotoxic therapies for metastatic disease

• No concurrent St. John's wort or rifampin

• No non-steroidal anti-inflammatory drugs (NSAIDs) for 2 days before (5 days for long-acting NSAIDs), during, and for 2 days after pemetrexed disodium administration (group 2)

• Concurrent anticoagulation treatment with warfarin or heparin allowed

Study Design

Allocation: Non-Randomized, Endpoint Classification: Safety Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Related Conditions & MeSH terms

• Unspecified Adult Solid Tumor, Protocol Specific

Intervention

Drug:
• carboplatin
Given IV
• cisplatin
Given IV
• etoposide
Given IV
• pemetrexed disodium
Given IV
• sorafenib tosylate
Given orally

Locations

Country	Name	City	State
United States	Lineberger Comprehensive Cancer Center at University of North Carolina - Chapel Hill	Chapel Hill	North Carolina

Sponsors (2)

Lead Sponsor	Collaborator
UNC Lineberger Comprehensive Cancer Center	National Cancer Institute (NCI)

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Recommended phase II dose and maximum tolerated dose of sorafenib tosylate when administered in combination with cisplatin and etoposide or carboplatin and pemetrexed disodium		12 months	Yes
Secondary	Toxicity		12 months	Yes
Secondary	Efficacy of treatment as measured by RECIST criteria or by tumor markers		36 months	No
Secondary	Pharmacokinetics of sorafenib tosylate in combination with etoposide (samples are no longer being collected and studies are no longer being performed as of 1/8/09)		24 months	No