Optimising the Propranolol Block Model

Pulmonary Disease, Chronic Obstructive Clinical Trial

Official title:

A Study to Optimise the Propranolol Block Model for Assessment of the Pharmacological Activity of Bronchodilators in Healthy Volunteers.

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00549120
• Other study ID #: MAB104954
• Status: Completed
• Phase: Phase 1
• First received: October 23, 2007
• Last updated: August 2, 2017
• Start date: August 15, 2007
• Est. completion date: October 26, 2007

Study information

• Verified date: August 2017
• Source: GlaxoSmithKline
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Optimising the propranolol block model

Description:

The bronchodilatory effects of inhaled beta2 agonists and anti-muscarinic drugs are the mainstay of symptomatic treatment of asthma and Chronic Obstructive Pulmonary Disease (COPD). A new approach is to combine both pharmacological approaches in a single molecule - ie a dual pharmacophore. It will be necessary to explore the relative contribution of the beta2 agonist versus anti-muscarinic bronchodilator properties of such a molecule. One way to do that is to block one of the components. Inhibition of beta2 agonist-mediated bronchodilatation by the non-selective beta-blocker propranolol is an established experimental method. Therefore this method may be useful in exploring the pharmacology of a dual pharmacophore.

Published studies have generally looked at the effect of a single dose of propranolol on a beta2 agonist over a relatively short period of time (a few hours). There is a desire to develop long acting bronchodilators that require once daily dosing only. Thus any dual pharmacophore developed is likely to have 24 hour duration of action after a single dose. Therefore to use this method of beta blockade to inhibit beta2 agonist mediated bronchodilation, it is necessary to confirm a dosing regimen of propranolol that has acceptable tolerability and is effective in blocking the effects of a beta2 agonist over 24 hours. That is the main purpose of this study.

It is also important to confirm that the bronchodilator effect of an antimuscarinic is unaffected by beta blockade. In addition, it is of interest to examine the bronchodilator effect of a combination of an antimuscarinic and beta2 agonist in healthy volunteers and the effect of propranolol on the combination.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 18
• Est. completion date: October 26, 2007
• Est. primary completion date: October 26, 2007
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 50 Years

Eligibility

Inclusion Criteria:

• Healthy adult male or female aged between 18 and 50 years.

• Body mass index within the range 19-29.9 kilograms/metre2

• Forced Expiratory Volume in 1 second (FEV1) >80% predicted and a FEV1/ Forced Vital Capacity (FVC) ratio > 0.7

• The subject has an increase in sGAW of >% over pre-dose baseline within 2 h of administration of 400 ug salbutamol by MDI inhaler at screening or in the 3 months before screening.

• Subject has an increase in sGaw of 25% over pre-dose baseline within 2 h following 40 ug ipratropium bromide at screening or in the 3 months before screening

• Subjects are current non-smokers who have not used any tobacco products in the 6-month period preceding the screening visit and have a pack history of < 10 pack years.

Exclusion criteria:

• A past or present disease, which as judged by the Investigator and medical monitor may affect the outcome of the study or the safety of the subject

• History of respiratory disease

• Significant abnormal 12 lead ECG, QTc(B) and QTc(F) value at screening >450msec on an individual ECG or a PR interval outside the range 120-210 msec

• Supine mean heart rate outside the range 45-90 beats per minute (bpm) at screening

• Subject has donated a unit of blood within the 56 days or intends to donate within 56 days after completing the study

• Subject is currently taking regular (or course of) medication whether prescribed or not (with the exception of contraceptives, including vitamins and herbal remedies such as St John's Wort)

• Subject has participated in a clinical study with a New Chemical Entity (NCE) within the past 1 month

• Infected with the Hepatitis B, Hepatitis C, or HIV virus

• Subject has a history of drug or other allergy, which, in the opinion of the Investigator, contraindicates their participation

Related Conditions & MeSH terms

• Chronic Disease
• Lung Diseases
• Pulmonary Disease, Chronic Obstructive

Intervention

Drug:
• Propranolol
40 mg tablets
• Salbutamol
Metered dose inhaler (600 µg)
• Ipratropium
Metered dose inhaler (40 µg)
• Placebo
Placebo for propranolol tablets

Locations

Country	Name	City	State
United Kingdom	GSK Investigational Site	London

Sponsors (1)

Lead Sponsor	Collaborator
GlaxoSmithKline

Country where clinical trial is conducted

United Kingdom, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Specific airway conductance (sGAW)		Pre-dose and up to 26 h post-dose
Secondary	Tolerability: adverse events, 12 lead ECG, blood pressure and heart rate		Study duration
Secondary	Propranolol pharmacokinetics		Pre-dose and up to 28 h post-dose

External Links

•   Researchers can use this site to request access to anonymised patient level data and/or supporting documents from clinical studies to conduct further research.
•   Results for study MAB104954 can be found on the GSK Clinical Study Register.