GnRH Agonist and Antagonists in an Oocyte Donation Program

Effect of Two Protocols of Ovarian Stimulation on Oocyte Quality Clinical Trial

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00505817
• Other study ID #: VLC-MM-0706-307-19
• Status: Completed
• Phase: Phase 4
• First received: July 23, 2007
• Last updated: January 9, 2009

Study information

• Verified date: January 2009
• Source: Instituto Valenciano de Infertilidad, IVI VALENCIA
• Contact: n/a
• Is FDA regulated: No
• Health authority: Spain: Ministry of Health
• Study type: Interventional

Clinical Trial Summary

The primary purpose of this study is to evaluate the effect of the two different protocols (long protocol vs antagonist protocol) on oocyte / embryo quality.

Description:

The cycles with antagonists of the GnRHa present a series of advantages with respect the GnRHa in an oocyte donation program: treatment cycles are simpler and shorter, a lower amount of dose of gonadotrophins is needed for stimulation, and most important, a decreased rate of ovarian hyperstimulation syndrome is observed. Nevertheless, several clinical trials relate their use to a greater rate of abortion and worse oocyte/ embryo quality. In order to discriminate the endometrial factor from the quality of oocyte cohort, the best strategy is the oocyte donation model. In the present study, for the first time, the effect of different protocols (long versus antagonist protocol) will be studied in the same donor, acting as its own control, undergoing COH. We will compare the COH´s parameters and IVF outcome obtained in the same donor submitted to, firstly, GnRH antagonist protocol (Cetrorelix- n= 45) versus another consecutive cycle with long protocol (Ac. Leuprolide- n= 45).

Recruitment information / eligibility

• Status: Completed
• Enrollment: 0
• Gender: Female
• Age group: 18 Years to 34 Years

Eligibility

Inclusion Criteria:

• oocyte donors with age range: 18 - 34; BMI: 18 - 29 kg/m2;

Exclusion Criteria:

• PCO

Study Design

Allocation: Non-Randomized, Intervention Model: Crossover Assignment, Masking: Open Label

Related Conditions & MeSH terms

• Effect of Two Protocols of Ovarian Stimulation on Oocyte Quality

Intervention

Drug:
• Cetrorelix and Leuprolide

Locations

Country	Name	City	State
Spain	Instituto Valenciano de Infertilidad Spain	Valencia

Sponsors (1)

Lead Sponsor	Collaborator
Instituto Valenciano de Infertilidad, IVI VALENCIA

Country where clinical trial is conducted

Spain,